Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Nicholas J. Murgolo"'
Autor:
Xinwei Sher, Michael Costanzo, Kristine Devito, Catherine A. McLellan, Susan Lindquist, Qian Si, Hao Wang, Nicholas J. Murgolo, Terry Roemer, Charles G. Garlisi, Guy H. Harris, Paul A. Mann, Sandra Koseoglu, Elena Kuzmin, Bo Jiang, Nuria de Pedro, Amy M. Flattery, Charles Boone, Jennifer Nielsen Kahn, Olga Genilloud
Publikováno v:
ACS Infectious Diseases
Steadily increasing antifungal drug resistance and persistent high rates of fungal-associated mortality highlight the dire need for the development of novel antifungals. Characterization of inhibitors of one enzyme in the GPI anchor pathway, Gwt1, ha
Autor:
Ada Solidar, Eric L. Gustafs, Nicholas J. Murgolo, Ping Qiu, Gerald J. Wyckoff, Peter M. A. Groenen, Qing Zhang, Jonathan R. Greene, Ellie D. Norris, Wynand Alkema, Jan P. G. Klomp, Wei Ding
Publikováno v:
American Journal of Drug Discovery and Development. 2:184-193
Autor:
D. M. Zhang, Lyne Levesque, P. VanderVere, Gang Yu, Paul E. Fraser, Masaki Nishimura, Nicholas J. Murgolo, Catherine D. Strader, D. M. Xu, Ekaterina Rogaeva, Luquan Wang, Monika Duthie, Yan Liang, Haung Yu, Marvin L. Bayne, P. St. George-Hyslop, M. Ikeda, G. Levesque, Johanna M. Rommens
Publikováno v:
Journal of Neurochemistry. 72:999-1008
Missense substitutions in the presenilin 1 (PS1) and presenilin 2 (PS2) proteins are associated with early-onset familial Alzheimer's disease. We have used yeast-two-hybrid and coimmunoprecipitation methods to show that the large cytoplasmic loop dom
Autor:
Marybeth S. Burton, Marvin L. Bayne, Sue Ann Kocsi, Kim A. O’Neill, Ruben Abagyan, Michael F. Czarniecki, Frederick J. Monsma, Brian E. Hawes, Andrew Orry, Nicholas J. Murgolo, Johannes H. Voigt, Heather Hine, Claudio N. Cavasotto
Publikováno v:
Journal of Medicinal Chemistry. 51:581-588
Melanin-concentrating hormone receptor 1 (MCH-R1) is a G-protein-coupled receptor (GPCR) and a target for the development of therapeutics for obesity. The structure-based development of MCH-R1 and other GPCR antagonists is hampered by the lack of an
Autor:
M. Gladys Arreaza, Maureen Laverty, Eric L. Gustafson, Andrei Golovko, Frederick J. Monsma, Ping Qiu, Joseph A. Hedrick, Qing Zhang, Jason S. Simon, Loretta A. Bober, Jonathan R. Greene, Marvin L. Bayne, Alberto Rojas-Triana, Galya Vassileva, Nicholas J. Murgolo
Publikováno v:
Genomics. 90(5):629-635
Mice lacking GPR103A expression display osteopenia. Analysis of mouse quantitative trait loci literature associated with bone mineral density suggested GPR103A ligand P518/Qrfp (chromosome 2qB) as a candidate osteoporosis gene. Promoter and coding re
Autor:
Erika Billick, Michael J. Endres, Bahige M. Baroudy, Alexandra Trkola, Pavel Pugach, Shawn E. Kuhmann, Tom Ketas, Nicholas J. Murgolo, Thomas P. Sakmar, Christoph Seibert, John P. Moore, Gregory R. Reyes, Elizabeth Coates
Publikováno v:
Journal of Virology. 78:4134-4144
AD101 and SCH-C are two chemically related small molecules that inhibit the entry of human immunodeficiency virus type 1 (HIV-1) via human CCR5. AD101 also inhibits HIV-1 entry via rhesus macaque CCR5, but SCH-C does not. Among the eight residues tha
Autor:
Glen Tetzloff, Xiaorui Yao, Lizbeth M. Hoos, Scott W. Altmann, Harry R. Davis, Ming Zeng, Michael P. Graziano, Luquan Wang, Li-ji Zhu, Sai Prasad N. Iyer, Andrei Golovko, Nicholas J. Murgolo, Maureen Maguire
Publikováno v:
Science. 303:1201-1204
Dietary cholesterol consumption and intestinal cholesterol absorption contribute to plasma cholesterol levels, a risk factor for coronary heart disease. The molecular mechanism of sterol uptake from the lumen of the small intestine is poorly defined.
Autor:
Ming Zeng, Suke Wang, Maureen Laverty, Ying Jiang, Jonathan R. Greene, Frederick J. Monsma, Nicholas J. Murgolo, Lin Luo, Ping Qiu, Luquan Wang, Jiang Behan, Galya Vassileva, Marvin L. Bayne, Deepmala Yadav, Eric L. Gustafson, Thomas M. Laz, Fang L. Zhang
Publikováno v:
Journal of Biological Chemistry. 278:27652-27657
Orphan G-protein-coupled receptors are a large class of receptors whose cognate ligands are unknown. SP9155 (also referred to as AQ27 and GPR103) is an orphan G-protein-coupled receptor originally cloned from a human brain cDNA library. SP9155 was fo
Autor:
Ying Jiang, Sergio A. Lira, Bahige M. Baroudy, Shu-Cheng Chen, Susan J. Abbondanzo, Galya Vassileva, Daniel M. Gorman, Kristian K. Jensen, Nicholas J. Murgolo, Ming Zeng
Publikováno v:
The Journal of Immunology. 170:5748-5755
IFN-κ belongs to a recently identified subclass of type I IFNs. In this study, we report the cloning and preliminary characterization of the murine homologue of IFN-κ. The gene encodes a 200-aa protein which is 38.5% homologous to human IFN-κ. Mur
Autor:
Yanbin Yin, Gang Fang, Jonathan R. Greene, Ge Gao, Jingchu Luo, Eric L. Gustafson, Joseph A. Hedrick, Ying Jiang, Maureen Laverty, Nicholas J. Murgolo, Marvin L. Bayne, Yong Zhang
Publikováno v:
Mammalian Genome. 14:341-349
PepPat, a hybrid method that combines pattern matching with similarity scoring, is described. We also report PepPat's application in the identification of a novel tachykinin-like peptide. PepPat takes as input a query peptide and a user-specified reg