Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Nicholas J. Kramer"'
Autor:
Rui Tang, Christopher W Murray, Ian L Linde, Nicholas J Kramer, Zhonglin Lyu, Min K Tsai, Leo C Chen, Hongchen Cai, Aaron D Gitler, Edgar Engleman, Wonjae Lee, Monte M Winslow
Publikováno v:
eLife, Vol 9 (2020)
Cell-cell interactions influence all aspects of development, homeostasis, and disease. In cancer, interactions between cancer cells and stromal cells play a major role in nearly every step of carcinogenesis. Thus, the ability to record cell-cell inte
Externí odkaz:
https://doaj.org/article/13a418d59ffc4122921111ddb10c3638
Autor:
Lindsey D. Goodman, Mercedes Prudencio, Nicholas J. Kramer, Luis F. Martinez-Ramirez, Ananth R. Srinivasan, Matthews Lan, Michael J. Parisi, Yongqing Zhu, Jeannie Chew, Casey N. Cook, Amit Berson, Aaron D. Gitler, Leonard Petrucelli, Nancy M. Bonini
Publikováno v:
Nature Neuroscience.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc7602096e29136da8f37cfc01affd94
https://doi.org/10.1038/s41593-023-01274-y
https://doi.org/10.1038/s41593-023-01274-y
Autor:
Nicholas J. Kramer, Gyan Prakash, Karine Choquet, Iliana Soto, Boryana Petrova, Hope E. Merens, Naama Kanarek, L. Stirling Churchman
Publikováno v:
bioRxiv
Mitochondrial oxidative phosphorylation (OXPHOS) complexes are assembled from proteins encoded by both nuclear and mitochondrial DNA. These dual-origin enzymes pose a complex gene regulatory challenge for cells, in which gene expression must be coord
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8754467e736fc1201806a2151d50263
https://europepmc.org/articles/PMC9934615/
https://europepmc.org/articles/PMC9934615/
Autor:
Nicholas J Kramer, Aaron D Gitler
Publikováno v:
eLife, Vol 5 (2016)
The regeneration of axons relies on a previously unknown mechanism that involves the regulation of alternative splicing by CELF proteins.
Externí odkaz:
https://doaj.org/article/f69d2768596e4c6dba5aba8caab6260a
Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD
Autor:
Casey Cook, Michael Parisi, Luis F. Martinez-Ramirez, Ananth R. Srinivasan, Nicholas J. Kramer, Nancy M. Bonini, Jeannie Chew, Amit Berson, Aaron D. Gitler, Yongqing Zhu, Matthews Lan, Mercedes Prudencio, Lindsey D. Goodman, Leonard Petrucelli
Publikováno v:
Nature neuroscience
An expanded GGGGCC hexanucleotide of more than 30 repeats (termed (G4C2)30+) within C9orf72 is the most prominent mutation in familial frontotemporal degeneration (FTD) and amyotrophic lateral sclerosis (ALS) (termed C9+). Through an unbiased large-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38d770f243bd7acdd7da6f181ec35a4
http://europepmc.org/articles/PMC6535128
http://europepmc.org/articles/PMC6535128
Autor:
Aaron D. Gitler, Leo C Chen, Nicholas J. Kramer, Christopher W. Murray, Edgar G. Engleman, Hongchen Cai, Wonjae Lee, Rui Tang, Ian L. Linde, Min K. Tsai, Zhonglin Lyu, Monte M. Winslow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44b044f52fc7a5ad5fd57556326dbabc
https://doi.org/10.7554/elife.61080.sa2
https://doi.org/10.7554/elife.61080.sa2
Autor:
Monte M. Winslow, Rui Tang, Hongchen Cai, Min K. Tsai, Nicholas J. Kramer, Christopher W. Murray, Aaron D. Gitler, Wonjae Lee, Edgar G. Engleman, Zhonglin Lyu, Leo C Chen, Ian L. Linde
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Cell-cell interactions influence all aspects of development, homeostasis, and disease. In cancer, interactions between cancer cells and stromal cells play a major role in nearly every step of carcinogenesis. Thus, the ability to record cell-cell inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b2c5d45dbc2a3068b8c7875a7e6fab
http://europepmc.org/articles/PMC7682987
http://europepmc.org/articles/PMC7682987
Autor:
Rachel M. Bleich, Jonathan W. Bogart, Aneta Turlik, R. Thomas Williamson, Daniel S. Catlin, Albert A. Bowers, Frank C. Schroeder, Nicholas J. Kramer, Satish K. Nair, K. N. Houk
Publikováno v:
J Am Chem Soc
Thiopeptides are a broad class of macrocyclic, heavily modified peptide natural products that are unified by the presence of a substituted, nitrogen-containing heterocycle core. Early work indicated that this core might be fashioned from two dehydroa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3e6702c677c651de4b951f83d72031
https://pubmed.ncbi.nlm.nih.gov/32609512
https://pubmed.ncbi.nlm.nih.gov/32609512
Autor:
Helen F. Sneddon, Rodolfo Cadilla, Young Do, Jeffrey Guss, Gordon Saxty, Paresh I. Masuria, Caterina Musetti, J. Darren Stuart, Beth Pietrak, Daniela Ennulat, Andrew G. King, Barry G. Shearer, Nicholas J. Kramer, Peckham Gregory, Chuck Poole, Alan R. Rendina, Daniel J. Price, H. Fritz Kramer, Tiahshun Xu, Girish Sati, Stephen A. Thomson, Patricia A. Elkins, Jason A. Holt, Alan V. McDougal, Joseph W. Wilson, Susan B. Laffan, Michael R. Jeune, Jan Klapwijk, Dean N. Thomas, Mark Youngman, Paris Ward, Paul N. Mortenson, Lisa M. Shewchuk, Eugene L. Stewart, David N. Deaton
Publikováno v:
Bioorganicmedicinal chemistry. 28(23)
GlaxoSmithKline and Astex Pharmaceuticals recently disclosed the discovery of the potent H-PGDS inhibitor GSK2894631A 1a (IC50 = 9.9 nM) as part of a fragment-based drug discovery collaboration with Astex Pharmaceuticals. This molecule exhibited good
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0464fe491c8ae02c9501daac98d3f990
https://pubmed.ncbi.nlm.nih.gov/33059303
https://pubmed.ncbi.nlm.nih.gov/33059303
Autor:
Rui Tang, Christopher W. Murray, Ian Linde, Nicholas J. Kramer, Zhonglin Lyu, Min K. Tsai, Leo Chen, Hongchen Cai, Aaron D. Gitler, Edgar Engleman, Wonjae Lee, Monte M. Winslow
Cell-cell interactions influence all aspects of development, homeostasis, and disease. In cancer, interactions between cancer cells and stromal cells play a major role in nearly every step of carcinogenesis. Thus, the ability to record cell-cell inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4abac9b32c3debe414697c11bd1b1207
https://doi.org/10.1101/2020.02.01.929877
https://doi.org/10.1101/2020.02.01.929877