Zobrazeno 1 - 10 of 54 pro vyhledávání: '"Nicholas J. Jacobs"'
1
Akademický článek
Profiling of Bacterial and Fungal Microbial Communities in Cystic Fibrosis Sputum Using RNA
Autor: Nora Grahl, Emily L. Dolben, Laura M. Filkins, Alex W. Crocker, Sven D. Willger, Hilary G. Morrison, Mitchell L. Sogin, Alix Ashare, Alex H. Gifford, Nicholas J. Jacobs, Joseph D. Schwartzman, Deborah A. Hogan
Publikováno v: mSphere, Vol 3, Iss 4 (2018)
ABSTRACT Here, we report an approach to detect diverse bacterial and fungal taxa in complex samples by direct analysis of community RNA in one step using NanoString probe sets. We designed rRNA-targeting probe sets to detect 42 bacterial and fungal g
Externí odkaz: https://doaj.org/article/e00226b7180942a295dba54c63ab9bf1
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2
Akademický článek
Control of Candida albicans Metabolism and Biofilm Formation by Pseudomonas aeruginosa Phenazines
Autor: Diana K. Morales, Nora Grahl, Chinweike Okegbe, Lars E. P. Dietrich, Nicholas J. Jacobs, Deborah A. Hogan
Publikováno v: mBio, Vol 4, Iss 1 (2013)
ABSTRACT Candida albicans has developmental programs that govern transitions between yeast and filamentous morphologies and between unattached and biofilm lifestyles. Here, we report that filamentation, intercellular adherence, and biofilm developmen
Externí odkaz: https://doaj.org/article/6f2c7f41a4284406bf7ecdf177e66c8d
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3
Pseudomonas aeruginosa Ethanol Oxidation by AdhA in Low-Oxygen Environments
Autor: Alex W. Crocker, Pedro Salazar, Deborah A. Hogan, John H. Hammond, Colleen E. Harty, Sven D. Willger, Nicholas J. Jacobs, Nico J. Botelho
Publikováno v: J Bacteriol
Pseudomonas aeruginosa has a broad metabolic repertoire that facilitates its coexistence with different microbes. Many microbes secrete products that P. aeruginosa can then catabolize, including ethanol, a common fermentation product. Here, we show t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d34ecfa80f2708f15c5d3b588f19db72
https://doi.org/10.1128/jb.00393-19
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4
Pseudomonas aeruginosa ethanol oxidation by AdhA in low oxygen environments
Autor: Pedro Salazar, Alex W. Crocker, Deborah A. Hogan, Nicholas J. Jacobs, John H. Hammond, Sven D. Willger, Colleen E. Harty
Pseudomonas aeruginosahas a broad metabolic repertoire that facilitates its co-existence with different microbes. Many microbes secrete products thatP. aeruginosacan then catabolize, including ethanol, a common fermentation product. Here, we show tha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f1efac147c2f3bb6bd413c01c18893c
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5
Profiling of bacterial and fungal microbial communities in cystic fibrosis sputum using RNA
Autor: Joseph D. Schwartzman, Alix Ashare, Alex H. Gifford, Nora Grahl, Sven D. Willger, Nicholas J. Jacobs, Deborah A. Hogan, Mitchell L. Sogin, Emily L. Dolben, Alex W. Crocker, Hilary G. Morrison, Laura M. Filkins
Publikováno v: mSphere, Vol 3, Iss 4, p e00292-18 (2018)
mSphere, Vol 3, Iss 4 (2018)
mSphere
Here we demonstrate the use of an RNA-based analysis of specific taxa of interest, including bacteria and fungi, within microbial communities. This multiplex method may be useful as a means to identify samples with specific combinations of taxa and t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a75edca2e5dd7ba93bcdaa5eff24dd
https://doi.org/10.1101/336230
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7
Antifungal mechanisms by which a novel Pseudomonas aeruginosa phenazine toxin kills Candida albicans in biofilms
Autor: Nicholas J. Jacobs, Sathish Rajamani, Diana K. Morales, Malathy Krishnamurthy, Deborah A. Hogan, Juan R. Cubillos-Ruiz
Publikováno v: Molecular Microbiology. 78:1379-1392
Pseudomonas aeruginosa produces several phenazines including the recently described 5-methyl-phenazine-1-carboxylic acid (5MPCA), which exhibits a novel antibiotic activity towards pathogenic fungi such as Candida albicans. Here we characterize the u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf6f68bc8f83d5f036eb1a824b941d56
https://doi.org/10.1111/j.1365-2958.2010.07414.x
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9
Genetic factors influence ethanol-induced uroporphyria inHfe(?/?) mice
Autor: Judith M. Jacobs, Jacqueline F. Sinclair, Dominic J. Balestra, William J. Bement, Glenn S. Gerhard, Nicholas J. Jacobs, Nadia Gorman, George H. Elder, Peter R. Sinclair, Juliana G. Szakacs, Heidi W. Trask
Publikováno v: Hepatology. 40:942-950
Two major risk factors for porphyria cutanea tarda (PCT) are alcohol consumption and homozygosity for the C282Y mutation in the hereditary hemochromatosis gene (HFE). We recently described an animal model for alcohol-induced uroporphyria, using Hfe(-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb89a8dead517361505c509b1595c1a
https://doi.org/10.1002/hep.20402
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10
Glutathione-Dependent Oxidative Modification of Protoporphyrin and Other Dicarboxylic Porphyrins by Mammalian and Plant Peroxidases
Autor: F. Pont, Franz-Peter Montforts, J.S.L. Hier, Stephen O. Duke, Nicholas J. Jacobs, H.G. Kruszyna, Franck E. Dayan
Publikováno v: Biochemical and Biophysical Research Communications. 259:195-200
Protoporphyrin, an intermediate in heme and chlorophyll biosynthesis, can accumulate in human and plant tissues under certain pathological conditions and is a photosensitizer used in cancer phototherapy. We previously showed that protoporphyrin and t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e950cdfe3f82079ba8bfe4dfccfce8
https://doi.org/10.1006/bbrc.1999.0749
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