Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Nicholas J. Izzo"'
Autor:
Kelsie M. LaBarbera, Yvette I. Sheline, Nicholas J. Izzo, Carla M. Yuede, Lora Waybright, Raymond Yurko, Hannah M. Edwards, Woodrow D. Gardiner, Kaj Blennow, Henrik Zetterberg, Anne Börjesson-Hanson, Roger Morgan, Charles S. Davis, Robert J. Guttendorf, Lon S. Schneider, Steven DeKosky, Harry LeVine, Michael Grundman, Anthony O. Caggiano, John R. Cirrito, Susan M. Catalano, Mary E. Hamby
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/19f084bea18e49d6b821e4355697a8ba
Autor:
Martí Colom-Cadena, Tara Spires-Jones, Henrik Zetterberg, Kaj Blennow, Anthony Caggiano, Steven T. DeKosky, Howard Fillit, John E. Harrison, Lon S. Schneider, Phillip Scheltens, Willem de Haan, Michael Grundman, Christopher H. van Dyck, Nicholas J. Izzo, Susan M. Catalano, the Synaptic Health Endpoints Working Group
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-12 (2020)
Abstract Background Synapse damage and loss are fundamental to the pathophysiology of Alzheimer’s disease (AD) and lead to reduced cognitive function. The goal of this review is to address the challenges of forging new clinical development approach
Externí odkaz:
https://doaj.org/article/1df4eea74a444af7b16f1b08d1784dd1
Autor:
Ho Young Kim, Ji Youn Lee, Chia-Ju Hsieh, Aladdin Riad, Nicholas J. Izzo, Susan M. Catalano, Thomas J. A. Graham, Robert H. Mach
Publikováno v:
Journal of Medicinal Chemistry. 65:6261-6272
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b35c388fb4560cd68c04dd241417bfd
https://doi.org/10.1021/acs.jmedchem.2c00191
https://doi.org/10.1021/acs.jmedchem.2c00191
Exploration of Diazaspiro Cores as Piperazine Bioisosteres in the Development of σ2 Receptor Ligands
Autor:
Kuiying Xu, Chia-Ju Hsieh, Ji Youn Lee, Aladdin Riad, Nicholas J. Izzo, Gary Look, Susan Catalano, Robert H. Mach
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8259
A series of σ2R compounds containing benzimidazolone and diazacycloalkane cores was synthesized and evaluated in radioligand binding assays. Replacing the piperazine moiety in a lead compound with diazaspiroalkanes and the fused octahydropyrrolo[3,4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de5680c9e363ec19c3952e34f23507f4
https://pubmed.ncbi.nlm.nih.gov/35897835
https://pubmed.ncbi.nlm.nih.gov/35897835
Autor:
Ho Young, Kim, Ji Youn, Lee, Chia-Ju, Hsieh, Aladdin, Riad, Nicholas J, Izzo, Susan M, Catalano, Thomas J A, Graham, Robert H, Mach
Publikováno v:
Journal of medicinal chemistry. 65(8)
In this study, a panel of 46 compounds containing five different scaffolds known to have high σ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a825dc3de6ddeedbbeb47aba3a7760e
https://pubmed.ncbi.nlm.nih.gov/35404616
https://pubmed.ncbi.nlm.nih.gov/35404616
Autor:
Hank Safferstein, Kelsey Sadlek, Raymond Yurko, Kelsie Mozzoni, Courtney Rehak, Nicholas J. Izzo, Susan M. Catalano, Harry LeVine, Colleen S. Limegrover
Publikováno v:
Journal of Neurochemistry
Several mutations conferring protection against Alzheimer's disease (AD) have been described, none as profound as the A673T mutation, where carriers are four times less likely to get AD compared to noncarriers. This mutation results in reduced amyloi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c42aa939f20295bfdf92fbf8ea75fcd6
http://europepmc.org/articles/PMC8246829
http://europepmc.org/articles/PMC8246829
Autor:
Kelsie M. LaBarbera, Yingcai Wang, Nicholas J. Izzo, Yaodong Huang, Zhi-Jie Ni, Courtney Rehak, Gilbert M. Rishton, Gary C. Look, Raymond Yurko, Colleen S. Limegrover, Jason Zhang, Susan M. Catalano, Xiaodong Wu
Publikováno v:
ACS Med Chem Lett
[Image: see text] An unbiased phenotypic neuronal assay was developed to measure the synaptotoxic effects of soluble Aβ oligomers. A collection of CNS druglike small molecules prepared by conditioned extraction was screened. Compounds that prevented
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb7d609a044f4759fd8fa7433e74dda
https://europepmc.org/articles/PMC8436239/
https://europepmc.org/articles/PMC8436239/
Autor:
Susan M. Catalano, Hank Safferstein, Michael Grundman, Roger Morgan, Julie Pribyl, Kelsie Mozzoni, Steven T. DeKosky, Jason D. Lickliter, Michelle Higgin, Lon S. Schneider, Robert Guttendorf, Nicholas J. Izzo
Publikováno v:
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Background Elayta (CT1812) is a novel allosteric antagonist of the sigma-2 receptor complex that prevents and displaces binding of Aβ oligomers to neurons. By stopping a key initiating event in Alzheimer's disease, this first-in–class drug candida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62cf8079e5cf92f7fa5c76ca49864bc5
https://doi.org/10.1016/j.trci.2018.11.001
https://doi.org/10.1016/j.trci.2018.11.001
Autor:
Tara L. Spires-Jones, Monique Hooley, Colin Smith, Anton-Fernandez A, Jamie Rose, Susan M. Catalano, Makis Tzioras, Rosemary J. Jackson, J. H. Catterson, Nicholas J. Izzo, Claire L. Davies, Tempelaar R, Martí Colom-Cadena, Jane Tulloch, Sophie Dunnett
Synapse loss correlates with cognitive decline in Alzheimer’s disease (AD), and soluble amyloid beta (Aβ) is implicated in synaptic dysfunction and loss. An important knowledge gap is the lack of understanding of how synaptic accumulation of Aβ l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed92cd0edcf16138aa25188d4a80a123
https://doi.org/10.1101/2021.02.01.428238
https://doi.org/10.1101/2021.02.01.428238
Autor:
Carmen Abate, Meharvan Singh, Wayne D. Bowen, Tara L. Spires-Jones, Aladdin Riad, Martí Colom-Cadena, Susan M. Catalano, Robert H. Mach, Jinbin Xu, Michael A. Cahill, Nicholas J. Izzo
Publikováno v:
eNeuro
The σ-2 receptor (S2R) complex has been implicated in CNS disorders ranging from anxiety and depression to neurodegenerative disorders such as Alzheimer’s disease (AD). The proteins comprising the S2R complex impact processes including autophagy,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0bec3dea0ee98e16e90ca80ade3b668
http://europepmc.org/articles/PMC7643771
http://europepmc.org/articles/PMC7643771