Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Nicholas J. Gutowski"'
Autor:
Alex S. Ferecskó, Miranda J. Smallwood, Adrian Moore, Corin Liddle, Jia Newcombe, Janet Holley, Jacqueline Whatmore, Nicholas J. Gutowski, Paul Eggleton
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1375 (2023)
Background: Some neurodegenerative diseases have an element of neuroinflammation that is triggered by viral nucleic acids, resulting in the generation of type I interferons. In the cGAS-STING pathway, microbial and host-derived DNA bind and activate
Externí odkaz:
https://doaj.org/article/bab224abafdd411e81d819454cea83de
Autor:
Md Zahidul I. Pranjol, Dmitry A. Zinovkin, Annelie R. T. Maskell, Laura J. Stephens, Sergey L. Achinovich, Dmitry M. Los’, Eldar A. Nadyrov, Michael Hannemann, Nicholas J. Gutowski, Jacqueline L. Whatmore
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-15 (2019)
Abstract Background New treatment options for metastasised high-grade serous carcinoma (HGSC) are urgently needed. HGSC frequently metastasises to the omentum, inducing angiogenesis in the local omental microvasculature to facilitate tumour growth. W
Externí odkaz:
https://doaj.org/article/3e0d6805e1ea4137bb0c6c2a8adc6f74
Autor:
Jacqueline L. Whatmore, Nicholas J. Gutowski, Layla Burn, Georgios Giamas, Zahidul Islam Pranjol
Publikováno v:
Frontiers in bioscience (Landmark edition). 26(9)
Tumour metastasis to the brain is a complex process involving crosstalk between the circulating tumour cells and the blood brain barrier (BBB). Astrocytes, which reside in the abluminal surface of the microvasculature of the BBB, are now known to pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9fa59f90aa7c071e599a208551faa94
https://pubmed.ncbi.nlm.nih.gov/34590469
https://pubmed.ncbi.nlm.nih.gov/34590469
Autor:
Nicholas J. Gutowski, Eva Latorre, Janet E. Holley, Jed J. Lye, Ben P. Lee, Lorna W. Harries, Stefania Bandinelli, Luigi Ferrucci
Publikováno v:
GeroScience. 41:561-573
The accumulation of senescent cells in tissues is causally linked to the development of several age-related diseases; the removal of senescent glial cells in animal models prevents Tau accumulation and cognitive decline. Senescent cells can arise thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f215946e0ccc35a08e041af28dec2c18
https://doi.org/10.1007/s11357-019-00100-3
https://doi.org/10.1007/s11357-019-00100-3
Publikováno v:
Current Cancer Drug Targets. 19:231-242
Background: Metastasis still remains the major cause of therapeutic failure, poor prognosis and high mortality in epithelial ovarian cancer (EOC) patients. Previously, we showed that EOC cells secrete a range of factors with potential pro-angiogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022843eaf6f7922a1151a836fc79d7c0
https://doi.org/10.2174/1568009618666180831123951
https://doi.org/10.2174/1568009618666180831123951
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1865:25-33
Epithelial ovarian cancer (EOC) frequently metastasises to the omentum, a process that requires pro-angiogenic activation of human omental microvascular endothelial cells (HOMECs) by tumour-secreted factors. We have previously shown that ovarian canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fcb281e6fe2958c8e4b2e7f8f9154a7
https://doi.org/10.1016/j.bbamcr.2017.10.005
https://doi.org/10.1016/j.bbamcr.2017.10.005
Autor:
Jed J, Lye, Eva, Latorre, Ben P, Lee, Stefania, Bandinelli, Janet E, Holley, Nicholas J, Gutowski, Luigi, Ferrucci, Lorna W, Harries
Publikováno v:
GeroScience
The accumulation of senescent cells in tissues is causally linked to the development of several age-related diseases; the removal of senescent glial cells in animal models prevents Tau accumulation and cognitive decline. Senescent cells can arise thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fcf8706579737c4993d3eaadfdcfcdfb
https://pubmed.ncbi.nlm.nih.gov/31654269
https://pubmed.ncbi.nlm.nih.gov/31654269
Publikováno v:
Practical Neurology. 18:156-158
Multifocal necrotising leucoencephalopathy is a rare disorder affecting the central nervous system. It is characterised pathologically by microscopic areas of necrosis with pontine predilection but also involvement of extrapontine regions, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f7e9f09eb18393facd1274e99657a99
https://doi.org/10.1136/practneurol-2017-001664
https://doi.org/10.1136/practneurol-2017-001664
Autor:
Paul Eggleton, Gary R. Smerdon, Janet E. Holley, Lucy Moore, Jia Newcombe, Nicholas J. Gutowski, Miranda Smallwood
Publikováno v:
Multiple Sclerosis and Related Disorders. 43:102084
Background Thousands of people with multiple sclerosis (MS) have used self-administered oxygen therapy in the UK. Clinical trials have been performed, with scant evidence that people with MS have been consulted to explore how they benefit from or how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4881b0274d374fed5052c4330f2cd6a
https://doi.org/10.1016/j.msard.2020.102084
https://doi.org/10.1016/j.msard.2020.102084
Publikováno v:
Biomolecules, Vol 5, Iss 4, Pp 3260-3279 (2015)
Biomolecules
Biomolecules
Epithelial ovarian cancer (EOC) is the leading cause of death from gynecologic malignancies and has a poor prognosis due to relatively unspecific early symptoms, and thus often advanced stage, metastasized cancer at presentation. Metastasis of EOC oc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b331f22f951819389c271f6ef035f0b5
https://doi.org/10.3390/biom5043260
https://doi.org/10.3390/biom5043260