Výsledky vyhledávání - "Nicholas J. Green"

Akademický článek

2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions

Autor: Rafał Szabla, Magdalena Zdrowowicz, Paulina Spisz, Nicholas J. Green, Petr Stadlbauer, Holger Kruse, Jiří Šponer, Janusz Rak

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)

UV-induced photodamage that likely occurred during the prebiotic synthesis of DNA and RNA is still an untackled issue for their origin on early Earth. Here, the authors show that substitution of 2,6-diaminopurine for adenine enables repair of cyclobu

Externí odkaz: https://doaj.org/article/347696f7b33c4b0fa6bc7bc725ea0853

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Prebiotic Synthesis of N-Formylaminonitriles and Derivatives in Formamide

Autor: Nicholas J. Green, David A. Russell, Sasha H. Tanner, John D. Sutherland

Publikováno v: Journal of the American Chemical Society. 145:10533-10541

Amino acids and their derivatives were probably instrumental in the transition of prebiotic chemistry to early biology. Accordingly, amino acid formation under prebiotic conditions has been intensively investigated. Unsurprisingly, most of these stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc3db1ca0f8d73f33135b6196955f10
https://doi.org/10.1021/jacs.2c13306

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Timescales for Prebiotic Photochemistry Under Realistic Surface Ultraviolet Conditions

Autor: David A. Russell, Dougal J. Ritson, Paul B. Rimmer, Samantha Thompson, John D. Sutherland, Jianfeng Xu, Didier Queloz, Nicholas J. Green

Publikováno v: Astrobiology

Ultraviolet (UV) light has long been invoked as a source of energy for prebiotic chemical synthesis, but experimental support does not involve sources of UV light that look like the young Sun. Here we experimentally investigate whether the UV flux av

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a8a5b112094f7a02bee091e3593e94c
https://doi.org/10.1089/ast.2020.2335

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Prebiotic Photochemical Coproduction of Purine Ribo- and Deoxyribonucleosides

Autor: David A. Russell, Ziwei Liu, Nicholas J. Green, Jianfeng Xu, John D. Sutherland

Publikováno v: Journal of the American Chemical Society

The hypothesis that life on Earth may have started with a heterogeneous nucleic acid genetic system including both RNA and DNA has attracted broad interest. The recent finding that two RNA subunits (cytidine, C, and uridine, U) and two DNA subunits (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9832b563fdc9de70ed02da088e4ae4f9
http://europepmc.org/articles/PMC8607323

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Illuminating Life’s Origins: UV Photochemistry in Abiotic Synthesis of Biomolecules

Autor: Jianfeng Xu, John D. Sutherland, Nicholas J. Green

Publikováno v: J Am Chem Soc

[Image: see text] Solar radiation is the principal source of energy available to Earth and has unmatched potential for the synthesis of organic material from primordial molecular building blocks. As well as providing the energy for photochemical synt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8411b535e98363a7e84c3ce828bb9a2d
https://doi.org/10.1021/jacs.1c01839

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Unified Total Synthesis of the Brevianamide Alkaloids Enabled by Chemical Investigations into their Biosynthesis

Autor: Andy Lawrence, Helen E. Jones, Robert C. Godfrey, Nicholas J. Green

The bicyclo[2.2.2]diazaoctane alkaloids are a vast group of natural products which have been the focus of attention from the scientific community for several decades. This interest stems from their broad range of biological activities, their diverse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10a6cbfa36250b1469ea1f9390b1734f
https://doi.org/10.33774/chemrxiv-2021-mpvpg

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Unified Total Synthesis of the Brevianamide Alkaloids Enabled by Chemical Investigations into their Biosynthesis

Autor: Robert C. Godfrey, Helen E. Jones, Nicholas J. Green, Andrew L. Lawrence

Publikováno v: Godfrey, R C, Jones, H E, Green, N J & Lawrence, A L 2021, ' Unified Total Synthesis of the Brevianamide Alkaloids Enabled by Chemical Investigations into their Biosynthesis ', Chemical Science . https://doi.org/10.1039/D1SC05801K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8efe84abea851cdd79a160aa935136
https://doi.org/10.26434/chemrxiv-2021-mpvpg

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2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions

Autor: Holger Kruse, Nicholas J. Green, Petr Stadlbauer, Paulina Spisz, Rafał Szabla, Janusz Rak, Magdalena Zdrowowicz, Jiří Šponer

Publikováno v: Szabla, R, Zdrowowicz, M, Spisz, P, Green, N J, Stadlbauer, P, Kruse, H, Šponer, J & Rak, J 2021, ' 2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions ', Nature Communications, vol. 12, no. 1, 3018 . https://doi.org/10.1038/s41467-021-23300-y
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications

High-yielding and selective prebiotic syntheses of RNA and DNA nucleotides involve UV irradiation to promote the key reaction steps and eradicate biologically irrelevant isomers. While these syntheses were likely enabled by UV-rich prebiotic environm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20039785210865012607d09f707cf26
https://hdl.handle.net/20.500.11820/cd9b0675-e082-48be-8960-cc026f227a96

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Total synthesis of brevianamide A

Autor: Andy Lawrence, Robert C. Godfrey, Nicholas J. Green, Gary S. Nichol

Publikováno v: Godfrey, R C, Green, N J, Nichol, G S & Lawrence, A L 2020, ' Total synthesis of brevianamide A ', Nature Chemistry, vol. 12, pp. 615-619 . https://doi.org/10.1038/s41557-020-0442-3

The fungal-derived bicyclo[2.2.2]diazaoctane alkaloids are of interest to the scientific community for their potent and varied biological activities. Within this large and diverse family of natural products, the insecticidal metabolite (+)-brevianami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b9227b648792d9ed7e105f69d2b625
https://www.pure.ed.ac.uk/ws/files/144682134/20200422_Lawrence_Brevianamide_A_Manuscript_Modified.pdf

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Bio‐inspired Domino oxa‐Michael/Diels–Alder/oxa‐Michael Dimerization of para ‐Quinols

Autor: Koen P. W. Rietdijk, Andy Lawrence, Catherine A. Connolly, Nicholas J. Green, Gary S. Nichol, Fernanda Duarte

Publikováno v: Green, N, Connolly, C, Rietdijk, K, Nichol, G, Duarte Gonzalez, F & Lawrence, A 2018, ' Bio-Inspired Domino oxa-Michael/Diels-Alder/oxa-Michael Dimerization of para-Quinols ', Angewandte Chemie International Edition, vol. 57, no. 21, pp. 6198-6202 . https://doi.org/10.1002/anie.201802125
Green, N J, Connolly, C A, Rietdijk, K P W, Nichol, G S, Duarte, F & Lawrence, A L 2018, ' Bio-inspired Domino oxa-Michael/Diels-Alder/oxa-Michael Dimerization of para-Quinols ', Angewandte Chemie International Edition, vol. 57, no. 21, pp. 6198-6202 . https://doi.org/10.1002/anie.201802125

A bio-inspired, pyrrolidine-mediated, dimerization of para-quinols has been developed. It represents one of the most complex, yet general, dimerization reactions ever disclosed, selectively forming four new bonds, four new rings, and eight new contig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86257deaf9ceff4527178ded352a79d8
https://doi.org/10.1002/anie.201802125

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