Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Nicholas J. Davies"'
Autor:
Ceri E. Oldreive, Anna Skowronska, Nicholas J. Davies, Helen Parry, Angelo Agathanggelou, Sergey Krysov, Graham Packham, Zbigniew Rudzki, Laura Cronin, Katerina Vrzalikova, Paul Murray, Elena Odintsova, Guy Pratt, A. Malcolm R. Taylor, Paul Moss, Tatjana Stankovic
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 11, Pp 1401-1412 (2015)
Chronic lymphocytic leukaemia (CLL) cells require microenvironmental support for their proliferation. This can be recapitulated in highly immunocompromised hosts in the presence of T cells and other supporting cells. Current primary CLL xenograft mod
Externí odkaz:
https://doaj.org/article/375d1d3350404f2199c867a0890e9f1f
Autor:
Angelo Agathanggelou, Victoria J. Weston, Tracey Perry, Nicholas J. Davies, Anna Skowronska, Daniel T. Payne, John S. Fossey, Ceri E. Oldreive, Wenbin Wei, Guy Pratt, Helen Parry, David Oscier, Steve J. Coles, Paul S. Hole, Richard L. Darley, Michael McMahon, John D. Hayes, Paul Moss, Grant S. Stewart, A. Malcolm R. Taylor, Tatjana Stankovic
Publikováno v:
Haematologica, Vol 100, Iss 8 (2015)
Inactivation of the Ataxia Telangiectasia Mutated gene in chronic lymphocytic leukemia results in resistance to p53-dependent apoptosis and inferior responses to treatment with DNA damaging agents. Hence, p53-independent strategies are required to ta
Externí odkaz:
https://doaj.org/article/043481b5ed054be7b760c0b02db05858
Autor:
Dragana Janic, Ceri E. Oldreive, Edward Smith, Philip J. Byrd, Tatjana Stankovic, Alexander J Taylor, Grant S. Stewart, Anna Skowronska, Lidija Dokmanovic, Nicholas J. Davies, Malcolm Taylor, Shankara Paneesha, Marwan Kwok, Sana Farhat, Guy Pratt, Paul Moss, Samuel Clokie, Manoj Raghavan
Publikováno v:
Leukemia & Lymphoma. 60:1823-1826
Partner and localizer of BRCA2 (PALB2), is a principal component of Homologous Recombination Repair (HRR) facilitating recruitment of HRR proteins such as BRCA1, BRCA2 and Rad51. Inherited inactiva...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::577e75518ca39a1ad07dcef91c166adc
https://doi.org/10.1080/10428194.2018.1551539
https://doi.org/10.1080/10428194.2018.1551539
Autor:
Farhat L Khanim, Rachel E Hayden, Jane Birtwistle, Alessia Lodi, Stefano Tiziani, Nicholas J Davies, Jon P Ride, Mark R Viant, Ulrich L Gunther, Joanne C Mountford, Heinrich Schrewe, Richard M Green, Jim A Murray, Mark T Drayson, Chris M Bunce
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8147 (2009)
BackgroundThe majority of acute myeloid leukaemia (AML) patients are over sixty years of age. With current treatment regimens, survival rates amongst these, and also those younger patients who relapse, remain dismal and novel therapies are urgently r
Externí odkaz:
https://doaj.org/article/9636c763c1a443abb133d3874ed80303
Autor:
Shankara Paneesha, Francesco Forconi, Helen Parry, Surita Dalal, Jingwen Mao, Peter Hillmen, Nicholas J. Davies, Duncan M. Baird, Paul Evans, Angelo Agathanggelou, Talha Munir, Tatjana Stankovic, A. Malcolm R. Taylor, Anshita Goel, Rhiannon E. Jones, Andrew D Beggs, Jean-Baptiste Cazier, Marwan Kwok, Archana Sharma-Oates, Naheema S. Gordon, Paul Moreton, Grigorios Papatzikas, Samantha Drennan, Andy C. Rawstron, Robert Hollows, Paul Moss, Edward Smith, Guy Pratt, Mayumi Hamada, Ceri E. Oldreive
Publikováno v:
Blood. 135(6)
Spontaneous regression is a recognized phenomenon in chronic lymphocytic leukemia (CLL) but its biological basis remains unknown. We undertook a detailed investigation of the biological and clinical features of 20 spontaneous CLL regression cases inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875e6cb6ec36ea12535f6d3a27e0ee11
https://pubmed.ncbi.nlm.nih.gov/31794600
https://pubmed.ncbi.nlm.nih.gov/31794600
Autor:
Natacha Veerapen, Christopher M. Bunce, Pedro Veliça, Ulrich L. Günther, Jonathan P. Ride, Mei Chong, Chathyan Pararasa, L. Rigoreau, Peter J. Winn, Farhat L. Khanim, Rohit Farmer, Nicholas J. Davies, E. Trivier, Mark T. Drayson, Rachel E. Hayden
Publikováno v:
British Journal of Cancer
Background: We and others have identified the aldo-keto reductase AKR1C3 as a potential drug target in prostate cancer, breast cancer and leukaemia. As a consequence, significant effort is being invested in the development of AKR1C3-selective inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40efd84eae7b9a5e02762e62bce5cc31
https://doi.org/10.1038/bjc.2014.83
https://doi.org/10.1038/bjc.2014.83
Autor:
Tracey Perry, Elliot J. Yates, Guy Pratt, Céline Reverdy, Sina Yadollahi, Pamela Kearns, Peter Hillmen, Tatjana Stankovic, Remi Delansorne, A. Malcolm R. Taylor, Paul Moss, Jingwen Mao, Anastasia Zlatanou, David Da Costa, Ceri E. Oldreive, Marwan Kwok, Nicholas J. Davies, Angelo Agathanggelou, Anna Skowronska, Helen Parry, Edward Smith, Shankara Paneesha, Grant S. Stewart
Publikováno v:
Blood. 130(2)
The role of deubiquitylase ubiquitin-specific protease 7 (USP7) in the regulation of the p53-dependent DNA damage response (DDR) pathway is well established. Whereas previous studies have mostly focused on the mechanisms underlying how USP7 directly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db345e2080d03b9d1e00e224b1889e1c
https://pubmed.ncbi.nlm.nih.gov/28705854
https://pubmed.ncbi.nlm.nih.gov/28705854
Autor:
Victoria Aldridge, Jonathan Frampton, Dean Kavanagh, Philip N. Newsome, Heather Beard, Patricia F. Lalor, Janine Youster, Neena Kalia, Nicholas J. Davies, David C. Bartlett, Abhilok Garg
Publikováno v:
Hepatology. 56:1063-1073
Human bone marrow mesenchymal stem cells (hMSCs) have shown benefit in clinical trials of patients with liver disease. Efficient delivery of cells to target organs is critical to improving their effectiveness. This requires an understanding of the me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50007cafa9d4704b8d48d5124742dea
https://doi.org/10.1002/hep.25716
https://doi.org/10.1002/hep.25716
Autor:
Christopher M. Bunce, Jonathan P. Ride, Claire Pearce, Naomi C. Wake, Jane Birtwistle, James K. Chipman, Rachel E. Hayden, Farhat L. Khanim, Nicholas J. Davies, Richard M. Green, Heinrich Schrewe
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 662:67-74
The aldo-keto reductase AKR1C3, has been shown to regulate myelopoiesis via its ability to metabolise prostaglandin D2 (PGD2). Other studies have demonstrated the oxidative activation of polycyclic aromatic hydrocarbon (PAH) procarcinogens by AKR1C3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876da9ef67bd0de8e875f4e96107542a
https://doi.org/10.1016/j.mrfmmm.2008.12.010
https://doi.org/10.1016/j.mrfmmm.2008.12.010
Autor:
Philipp Antzack, Nicholas J. Davies, Marina Vannucci, Francesco Falciani, Kim Clarke, Xiaodong Zhuang, Roy Bicknell, Ayesha S. Rahman, Moray J. Campbell, Zsuzsanna Nagy, John Herbert, Alberto Cassese, Michele Guindani, Victor Trevino
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, 12(4):e1004884. Public Library of Science
Trevino, V; Cassese, A; Nagy, Z; Zhuang, X; Herbert, J; Antzack, P; et al.(2016). A Network Biology Approach Identifies Molecular Cross-Talk between Normal Prostate Epithelial and Prostate Carcinoma Cells. PLoS Computational Biology, 12(4), e1004884. doi: 10.1371/journal.pcbi.1004884. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7pr1d2qj
PLoS computational biology, vol 12, iss 4
PLoS Computational Biology, Vol 12, Iss 4, p e1004884 (2016)
PLoS Computational Biology, 12(4):e1004884. Public Library of Science
Trevino, V; Cassese, A; Nagy, Z; Zhuang, X; Herbert, J; Antzack, P; et al.(2016). A Network Biology Approach Identifies Molecular Cross-Talk between Normal Prostate Epithelial and Prostate Carcinoma Cells. PLoS Computational Biology, 12(4), e1004884. doi: 10.1371/journal.pcbi.1004884. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7pr1d2qj
PLoS computational biology, vol 12, iss 4
PLoS Computational Biology, Vol 12, Iss 4, p e1004884 (2016)
The advent of functional genomics has enabled the genome-wide characterization of the molecular state of cells and tissues, virtually at every level of biological organization. The difficulty in organizing and mining this unprecedented amount of info
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76c5bc84122862c3446873804de0bf6
https://pubmed.ncbi.nlm.nih.gov/27749896
https://pubmed.ncbi.nlm.nih.gov/27749896