Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Nicholas J. Coltman"'
Publikováno v:
Heterocyclic Communications. 28:11-17
This research investigated the general high-throughput synthetic protocol for the accelerated synthesis of functionalized trifluoromethylpyrazolopyrimidines 3 and N-(5-cyano-3-methyl-1-phenyl-1H-pyrazol-4-yl) benzamide 4 from aminocyanopyrazole 1 pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::118c855d20d50c57bc70264e7b9a2e83
https://doi.org/10.1515/hc-2022-0001
https://doi.org/10.1515/hc-2022-0001
Autor:
Brandon A. Coke, Emma L. Shepherd, Nikolas J. Hodges, Kyriaki Chatzi, Timothy Schulz-utermoehl, Nicholas J. Coltman, Patricia F. Lalor
Publikováno v:
Toxicology Letters. 345:34-45
HepG2 cells continue to be a valuable tool in early drug discovery and pharmaceutical development. In the current study we develop a 3D in vitro liver model, using HepG2/C3A cells that is predictive of human genotoxic exposure. HepG2/C3A cells cultur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39c90cd3f26fe3ad2da53b92f73515f
https://doi.org/10.1016/j.toxlet.2021.04.004
https://doi.org/10.1016/j.toxlet.2021.04.004
Autor:
Nikolas J. Hodges, Ellen B Higgs, Nicholas J. Coltman, Frederik-Jan van Schooten, Roger W. L. Godschalk, Grant S. Stewart
Publikováno v:
Toxicology Letters, 332, 27-35. Elsevier Ireland Ltd
Reactive oxygen species (ROS) within the cell are rapidly detoxified by antioxidants such as glutathione. Depletion of glutathione will therefore increase levels of intracellular ROS, which can lead to oxidative DNA damage and the induction of apopto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b930347d9aed92e9e84241df52926951
https://doi.org/10.1016/j.toxlet.2020.06.019
https://doi.org/10.1016/j.toxlet.2020.06.019
Autor:
James S. Craig, Jane A. McKeating, Nikolas J. Hodges, Harriet J Hill, Zania Stamataki, Michael J. Hannon, Nicholas J. Coltman, Aditya Garai, Tasha Chauhan, Ross T Egan, Pawel Grzechnik, Catherine A J Hooper, Kinga Winczura, Scott P Davies, Lazaros Melidis
Publikováno v:
Angewandte Chemie (International Ed. in English)
Melidis, L, Hill, H J, Coltman, N J, Davies, S P, Winczura, K, Chauhan, T, Craig, J S, Garai, A, Hooper, C A J, Egan, R T, McKeating, J A, Hodges, N J, Stamataki, Z, Grzechnik, P & Hannon, M J 2021, ' Supramolecular Cylinders Target Bulge Structures in the 5′ UTR of the RNA Genome of SARS-CoV-2 and Inhibit Viral Replication** ', Angewandte Chemie-International Edition, vol. 60, no. 33, pp. 18144-18151 . https://doi.org/10.1002/anie.202104179
Angewandte Chemie
Melidis, L, Hill, H J, Coltman, N J, Davies, S P, Winczura, K, Chauhan, T, Craig, J S, Garai, A, Hooper, C A J, Egan, R T, McKeating, J A, Hodges, N J, Stamataki, Z, Grzechnik, P & Hannon, M J 2021, ' Supramolecular Cylinders Target Bulge Structures in the 5′ UTR of the RNA Genome of SARS-CoV-2 and Inhibit Viral Replication** ', Angewandte Chemie-International Edition, vol. 60, no. 33, pp. 18144-18151 . https://doi.org/10.1002/anie.202104179
Angewandte Chemie
The untranslated regions (UTRs) of viral genomes contain a variety of conserved yet dynamic structures crucial for viral replication, providing drug targets for the development of broad spectrum anti-virals. We combine in vitro RNA analysis with Mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d3577417459d639b00aa2ef4d9978f
https://ora.ox.ac.uk/objects/uuid:029eb55a-9ac5-4b54-91d7-aa94797f7bff
https://ora.ox.ac.uk/objects/uuid:029eb55a-9ac5-4b54-91d7-aa94797f7bff
Autor:
Alice Lanne, Yixin Cui, Edward Browne, Philip G. E. Craven, Nicholas J. Cundy, Nicholas J. Coltman, Katie Dale, Antonio Feula, Jon Frampton, Aaron Goff, Mariwan A. Hama Salih, Xingfen Lang, Xingjian Li, Christopher W. Moon, Michael Morton, Jordan Pascoe, Xudan Peng, Vanessa Portman, Cara Press, Timothy Schulz-Utermoehl, Micky Tortorella, Zhengchao Tu, Zoe E. Underwood, Changwei Wang, Akina Yoshizawa, Tianyu Zhang, Simon J Waddell, Joanna Bacon, Cleopatra Neagoie, John S. Fossey, Luke J. Alderwick.
Tuberculosis (TB) is the leading cause of global morbidity and mortality resulting from infectious disease, with over 10 million new cases and 1.5 million deaths in 2019. This global emergency is exacerbated by the emergence of multi-drug-resistant M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66e23350ab3888c21d9c850dce9078a6
https://doi.org/10.1101/2020.09.03.281170
https://doi.org/10.1101/2020.09.03.281170