Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Nicholas J. Chargo"'
Autor:
Nicholas J. Chargo, Ho Jun Kang, Subhashari Das, Yining Jin, Cheryl Rockwell, Jae Youl Cho, Laura R. McCabe, Narayanan Parameswaran
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The gut microbiota and barrier function play important roles in bone health. We previously demonstrated that chronic glucocorticoid (GC)-induced bone loss in mice is associated with significant shifts in gut microbiota composition and impaired gut ba
Externí odkaz:
https://doaj.org/article/1a27a5873df940dda961212053f16b7a
Autor:
Nicholas J. Chargo, Kerri Neugebauer, Douglas V. Guzior, Robert A. Quinn, Narayanan Parameswaran, Laura R. McCabe
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2024)
Glucocorticoid-induced osteoporosis (GIO) is a significant side effect of prolonged glucocorticoid (GC) treatment. Chronic GC treatment also leads to trabecular bone loss and gut microbiota dysbiosis in mice. The gut dysbiosis is mechanistically link
Externí odkaz:
https://doaj.org/article/0b500310cef242dfb741716d5cc38e3c
Autor:
Fernando B. Vergara-Hernandez, Brian D. Nielsen, John M. Popovich, Char L. Panek, Alyssa A. Logan, Cara I. Robison, Richard A. Ehrhardt, Tyler N. Johnson, Nicholas J. Chargo, Thomas H. Welsh, Amanda N. Bradbery, Jessica L. Leatherwood, Aimee C. Colbath
Publikováno v:
PLoS ONE, Vol 19, Iss 4 (2024)
Externí odkaz:
https://doaj.org/article/7dc1cfe0095b4c52adaf3b0eb03f09fe
Autor:
Kerri A. Neugebauer, Maxwell Okros, Douglas V. Guzior, Jeremiah Feiner, Nicholas J. Chargo, Madison Rzepka, Anthony L. Schilmiller, Sandra O’Reilly, A. Daniel Jones, Victoria E. Watson, James P. Luyendyk, Laura R. McCabe, Robert A. Quinn
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 12, Pp 100297- (2022)
Bile acids (BAs) are steroid detergents in bile that contribute to fat absorption, cell signaling, and microbiome interactions. The final step in their synthesis is amino acid conjugation with either glycine or taurine in the liver by the enzyme bile
Externí odkaz:
https://doaj.org/article/4d5c996a9607462c81dbbb41bd122fda
Autor:
Lauren K. Heine, Abby D. Benninghoff, Elizabeth A. Ross, Lichchavi D. Rajasinghe, James G. Wagner, Ryan P. Lewandowski, Alexa L. Richardson, Quan-Zhen Li, John P. Buchweitz, Justin Zyskowski, Ashleigh N. Tindle, Anna E. Skedel, Nicholas J. Chargo, Laura R. McCabe, Jack R. Harkema, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Autoimmune diseases can be triggered by environmental toxicants such as crystalline silica dust (cSiO2). Here, we characterized the dose-dependent immunomodulation and toxicity of the glucocorticoid (GC) prednisone in a preclinical model that emulate
Externí odkaz:
https://doaj.org/article/9d62c3f710e94b838f4b340305d3c650
Autor:
Michael J. Toscano, Sydney L. Baker, M. M. Makagon, Darrin M. Karcher, Nicholas J. Chargo, Cara I. Robison
Publikováno v:
Poultry Science. 98:1017-1022
Damage to the keel bone is a major issue in the laying hen industry. The goal of this study was to compare palpation results of live laying hens to digital computed tomography (CT) images, to assess changes in palpation reliability as training and fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17156184561f8995d25b55e3a1d6a608
https://doi.org/10.3382/ps/pey373
https://doi.org/10.3382/ps/pey373
Autor:
Cara I. Robison, Michael J. Toscano, Darrin M. Karcher, Sydney L. Baker, M. M. Makagon, Hope O. Akaeze, Nicholas J. Chargo
Publikováno v:
Chargo, Nicholas J.; Robison, Cara I.; Akaeze, Hope O.; Baker, Sydney L.; Toscano, Michael J.; Makagon, Maja M.; Karcher, Darrin M. (2019). Keel bone differences in laying hens housed in enriched colony cages. Poultry science, 98(2), pp. 1031-1036. Elsevier 10.3382/ps/pey421
Keel bone damage may be painful to birds and affect their production. In order to better understand the frequency, position, and timepoint of keel bone damage that occur during production, the integrity of W-36 laying hen keel bones housed in enriche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8cd53fabbb1c668d3b6e2c206dc5ab
https://pubmed.ncbi.nlm.nih.gov/30239903
https://pubmed.ncbi.nlm.nih.gov/30239903
Autor:
Nicholas J Chargo, Jonathan D Schepper, Naoimy Rios‐Arce, Ho Jun Kang, Joseph D Gardinier, Narayanan Parameswaran, Laura R McCabe
Publikováno v:
JBMR Plus, Vol 7, Iss 12, Pp n/a-n/a (2023)
ABSTRACT Glucocorticoids (GCs) are commonly used anti‐inflammatory medications with significant side effects, including glucocorticoid‐induced osteoporosis (GIO). We have previously demonstrated that chronic subcutaneous GC treatment in mice lead
Externí odkaz:
https://doaj.org/article/25d7a5965ca14fa3968fdeb4664b3415