Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Nicholas J. Amato"'
Autor:
Dario Garcia-Dominguez, Carole Henry, LingZhi Ma, Hardik Jani, Nicholas J. Amato, Taylor Manning, Alec Freyn, Heather Davis, Chiaowen Joyce Hsiao, Mengying Li, Hillary Koch, Sayda Elbashir, Anthony DiPiazza, Andrea Carfi, Darin Edwards, Kapil Bahl
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
For a vaccine to achieve durable immunity and optimal efficacy, many require a multi-dose primary vaccination schedule that acts to first “prime” naive immune systems and then “boost” initial immune responses by repeated immunizations (ie, pr
Externí odkaz:
https://doaj.org/article/7ceed16ea2d0483aa3c331e1bda0099f
Publikováno v:
Journal of Nucleic Acids, Vol 2013 (2013)
Damaged DNA, generated by the abstraction of one of five hydrogen atoms from the 2′-deoxyribose ring of the nucleic acid, can contain a variety of lesions, some of which compromise physiological processes. Recently, DNA damage, resulting from the f
Externí odkaz:
https://doaj.org/article/f73da28db5b843139d74ed7537923e46
Autor:
Suzanne M. Scheaffer, Diana Lee, Bradley Whitener, Baoling Ying, Kai Wu, Chieh-Yu Liang, Hardik Jani, Philippa Martin, Nicholas J. Amato, Laura E. Avena, Daniela Montes Berrueta, Stephen D. Schmidt, Sijy O’Dell, Arshan Nasir, Gwo-Yu Chuang, Guillaume Stewart-Jones, Richard A. Koup, Nicole A. Doria-Rose, Andrea Carfi, Sayda M. Elbashir, Larissa B. Thackray, Darin K. Edwards, Michael S. Diamond
Publikováno v:
Nature Medicine. 29:247-257
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bd7ad054a7a598402ef4b195148fcc2
https://doi.org/10.1038/s41591-022-02092-8
https://doi.org/10.1038/s41591-022-02092-8
Autor:
Jingsong Cao, Arianna Markel, Erin Hanahoe, Tatiana Ketova, Cosmin Mihai, Zach Zalinger, David Marquardt, Nicholas J. Amato, Yi Min Cheng, David W. Reid, Athanasios Dousis, Paloma H. Giangrande, Joshua R. Schultz, Paolo G. V. Martini, Patrick F. Finn
Publikováno v:
Amino Acids.
Glucose-6-phosphatase-α (G6Pase-α) catalyzes the hydrolysis of glucose-6-phosphate to glucose and functions as a key regulator in maintaining blood glucose homeostasis. Deficiency in G6Pase-α causes glycogen storage disease 1a (GSD1a), an inherite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4e2bf91a2922fe8e73782065e3ef7d7
https://doi.org/10.1007/s00726-023-03263-8
https://doi.org/10.1007/s00726-023-03263-8
Autor:
Suzanne M. Scheaffer, Diana Lee, Bradley Whitener, Baoling Ying, Kai Wu, Hardik Jani, Philippa Martin, Nicholas J. Amato, Laura E. Avena, Daniela Montes Berrueta, Stephen D. Schmidt, Sijy O’Dell, Arshan Nasir, Gwo-Yu Chuang, Guillaume Stewart-Jones, Richard A. Koup, Nicole A. Doria-Rose, Andrea Carfi, Sayda M. Elbashir, Larissa B. Thackray, Darin K. Edwards, Michael S. Diamond
Publikováno v:
bioRxiv
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants in the Omicron lineage has resulted in diminished Coronavirus Disease 2019 (COVID-19) vaccine efficacy and persistent transmission. In this study, we evaluated the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53da2e914bcba0cdf9252d53319d90f4
https://doi.org/10.1101/2022.09.12.507614
https://doi.org/10.1101/2022.09.12.507614
Publikováno v:
Chemical Research in Toxicology. 30:1127-1133
Genomic integrity is constantly challenged by a variety of endogenous and exogenous DNA damaging agents, which can lead to the formation of 104–105 DNA lesions per cell per day. Reactive oxygen species (ROS) represent a major type of DNA damaging a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28442a7f33879544b28d38c5905fc15d
https://doi.org/10.1021/acs.chemrestox.6b00439
https://doi.org/10.1021/acs.chemrestox.6b00439
Autor:
Shuo Liu, Yinsheng Wang, Candace R. Guerrero, Sanjeev Gupta, Yang Yu, Yogeshwar Sharma, Nicholas J. Amato
Publikováno v:
Molecular & Cellular Proteomics. 15:810-817
Defective copper excretion from hepatocytes in Wilson's disease causes accumulation of copper ions with increased generation of reactive oxygen species via the Fenton-type reaction. Here we developed a nanoflow liquid chromatography-nanoelectrospray
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104f76a917dbae264681a5db4fac2a45
https://doi.org/10.1074/mcp.m115.052696
https://doi.org/10.1074/mcp.m115.052696
Autor:
Matthew W. Ellis, Amanda C. Bryant-Friedrich, Raziya Shaik, Nicholas J. Amato, Matthew J. Starr
Publikováno v:
ChemBioChem. 16:2379-2384
It has been postulated that sugar radicals and related species are involved in oxidative events involving RNA. To determine the contribution, if any, of these species to the deleterious effects of the endogenous exposome, it is important to unambiguo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c00225f11a74f540a036310c193ab4
https://doi.org/10.1002/cbic.201500330
https://doi.org/10.1002/cbic.201500330
Publikováno v:
Environmental Science & Technology. 49:11923-11931
Arsenic toxicity is a serious public health problem worldwide that brings more than 100 million people into the risk of arsenic exposure from groundwater and food contamination. Although there is accumulating evidence linking arsenic exposure with ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eae9976ce253aa85d9fab24f1baa732
https://doi.org/10.1021/acs.est.5b03386
https://doi.org/10.1021/acs.est.5b03386
Publikováno v:
Nucleic Acids Research
DNA damage, arising from endogenous metabolism or exposure to environmental agents, may perturb the transmission of genetic information by blocking DNA replication and/or inducing mutations, which contribute to the development of cancer and likely ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00d49896f38a1b45dfc35d825fb806f
https://doi.org/10.1093/nar/gkv725
https://doi.org/10.1093/nar/gkv725