Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Nicholas J. Agard"'
Autor:
Luis F. Schachner, Christopher Mullen, Wilson Phung, Joshua D. Hinkle, Michelle Irwin Beardsley, Tracy Bentley, Peter Day, Christina Tsai, Siddharth Sukumaran, Tomasz Baginski, Danielle DiCara, Nicholas J. Agard, Matthieu Masureel, Joshua Gober, Adel M. ElSohly, Rafael Melani, John E. P. Syka, Romain Huguet, Michael T. Marty, Wendy Sandoval
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The heterogeneity inherent in today’s biotherapeutics, especially as a result of heavy glycosylation, can affect a molecule’s safety and efficacy. Characterizing this heterogeneity is crucial for drug development and quality assessment,
Externí odkaz:
https://doaj.org/article/1f51a60ae7254824a781e70ff1592428
Autor:
Danielle M. Dicara, Sunil Bhakta, Mary Ann Go, James Ziai, Ron Firestein, Bill Forrest, Chen Gu, Steven R. Leong, Genee Lee, Shang-Fan Yu, Andrew G. Polson, Nicholas J. Agard
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
T cell-engaging bispecific antibodies (TCEs) are clinically effective treatments for hematological cancers. While the utility of TCEs in solid malignancies is being explored, toxicities arising from antigen expression on normal tissues have slowed or
Externí odkaz:
https://doaj.org/article/12d36f5be34d41a0b9c3ffff1711d4e7
Autor:
Josefa Dela Cruz Chuh, MaryAnn Go, Yvonne Chen, Jun Guo, Hanine Rafidi, Danielle Mandikian, Yonglian Sun, Zhonghua Lin, Kellen Schneider, Pamela Zhang, Rajesh Vij, Danielle Sharpnack, Pamela Chan, Cecile de la Cruz, Jack Sadowsky, Dhaya Seshasayee, James T. Koerber, Thomas H. Pillow, Gail D. Phillips, Rebecca K Rowntree, C. Andrew Boswell, Katherine R. Kozak, Andrew G. Polson, Paul Polakis, Shang-Fan Yu, Peter S. Dragovich, Nicholas J. Agard
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Early success with brentuximab vedotin in treating classical Hodgkin lymphoma spurred an influx of at least 20 monomethyl auristatin E (MMAE) antibody-drug conjugates (ADCs) into clinical trials. While three MMAE-ADCs have been approved, most of thes
Externí odkaz:
https://doaj.org/article/25ec46df098b446591f757fd46270d3e
Autor:
Hadir Marei, Wen-Ting K. Tsai, Yee-Seir Kee, Karen Ruiz, Jieyan He, Chris Cox, Tao Sun, Sai Penikalapati, Pankaj Dwivedi, Meena Choi, David Kan, Pablo Saenz-Lopez, Kristel Dorighi, Pamela Zhang, Yvonne T. Kschonsak, Noelyn Kljavin, Dhara Amin, Ingrid Kim, Andrew G. Mancini, Thao Nguyen, Chunling Wang, Eric Janezic, Alexander Doan, Elaine Mai, Hongkang Xi, Chen Gu, Melanie Heinlein, Brian Biehs, Jia Wu, Isabelle Lehoux, Seth Harris, Laetitia Comps-Agrar, Dhaya Seshasayee, Frederic J. de Sauvage, Matthew Grimmer, Jing Li, Nicholas J. Agard, Felipe de Sousa e Melo
Publikováno v:
Nature. 610:182-189
Most current therapies that target plasma membrane receptors function by antagonizing ligand binding or enzymatic activities. However, typical mammalian proteins comprise multiple domains that execute discrete but coordinated activities. Thus, inhibi
Autor:
Yvonne Chen, Maciej Paluch, Julie A. Zorn, Sharmila Rajan, Brandon Leonard, Alberto Estevez, John Brady, Henry Chiu, Wilson Phung, Amin Famili, Minhong Yan, Claudio Ciferri, Marissa L. Matsumoto, Greg A. Lazar, Susan Crowell, Phil Hass, Nicholas J. Agard
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Treatment of ocular disease is hindered by the presence of the blood-retinal barrier, which restricts access of systemic drugs to the eye. Intravitreal injections bypass this barrier, delivering high concentrations of drug to the targeted tissue. How
Externí odkaz:
https://doaj.org/article/28ad3cfcdaf4459abab263005b66f32a
Autor:
Nicholas J. Agard, Gu Zhang, John Ridgeway, Danielle M. Dicara, Phillip Y. Chu, Rachana Ohri, Sarah Sanowar, Jean-Michel Vernes, Hannah Chi, Jiameng Zhang, Emily Holz, Maciej Paluch, Guannan He, Yingjia Benson, Jianhuan Zhang, Pamela Chan, Nga Tang, Prachi Javale, Blair Wilson, Kathy Barrett, Rebecca K. Rowntree, Julie Hang, Y. Gloria Meng, Phil Hass, Germaine Fuh, Robert Piskol, Vladimir Bantseev, Kelly M. Loyet, John C. Tran, Cong Wu, Vahan B. Indjeian, Vittal Shivva, Minhong Yan
Publikováno v:
Translational vision sciencetechnology. 11(10)
Diabetic macular edema (DME) is the leading cause of vision loss and blindness among working-age adults. Although current intravitreal anti-vascular endothelial growth factor (VEGF) therapies improve vision for many patients with DME, approximately h
Autor:
Robert F. Kelley, Devin B. Tesar, Yue Wang, Nicholas J. Agard, Patrick G. Holder, Joyce Chan, Laetitia Comps-Agrar, Judit Horvath, Joshua D. Horvath, Susan R. Crowell
Publikováno v:
Molecular pharmaceutics. 19(5)
Treatment of age-related macular degeneration (AMD) with anti-vascular endothelial growth factor (VEGF) biologic agents has been shown to restore and maintain visual acuity for many patients afflicted with wet AMD. These agents are usually administer
Autor:
Nicholas J. Agard, Peter S. Dragovich, Ryan L. Kelly, Shion A. Lim, Allison M. Beal, Ian Moench, Anna M. Gram, Pei-Pei Kung, Daša Lipovšek
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35ae0feec8bc4e0efe319f5c4f279989
https://doi.org/10.29200/acsmedchemrev-v56.ch22
https://doi.org/10.29200/acsmedchemrev-v56.ch22
Autor:
William F. DeGrado, Kathleen S. Molnar, James A. Wells, Rustem I. Litvinov, Joel S. Bennett, John W. Weisel, Karen P. Fong, Oleg Kim, Nicholas J. Agard
Publikováno v:
Blood advances. 5(23)
Blood clot contraction is driven by traction forces generated by the platelet cytoskeleton that are transmitted to fibrin fibers via the integrin αIIbβ3. Here we show that clot contraction is impaired by inhibitors of the platelet cytosolic proteas
Autor:
Brant Hubbard, Daša Lipovšek, Nicholas J. Agard, Suzana A. Kahn, Catherine A. Bolger, Allison M. Beal, Peter S. Dragovich
Publikováno v:
2020 Medicinal Chemistry Reviews ISBN: 9781734427400
2020 Medicinal Chemistry Reviews
2020 Medicinal Chemistry Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c99372add3e57e20d7de680f318c0d80
https://doi.org/10.29200/acsmedchemrev-v55.ch28
https://doi.org/10.29200/acsmedchemrev-v55.ch28