Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Nicholas J Westwood"'
Autor:
Anne Kelsen, Robyn S Kent, Anne K Snyder, Eddie Wehri, Stephen J Bishop, Rachel V Stadler, Cameron Powell, Bruno Martorelli di Genova, Pramod K Rompikuntal, Martin J Boulanger, David M Warshaw, Nicholas J Westwood, Julia Schaletzky, Gary E Ward
Publikováno v:
PLoS Biology, Vol 21, Iss 5, p e3002110 (2023)
Toxoplasma gondii is a widespread apicomplexan parasite that can cause severe disease in its human hosts. The ability of T. gondii and other apicomplexan parasites to invade into, egress from, and move between cells of the hosts they infect is critic
Externí odkaz:
https://doaj.org/article/f8190f34443b4f0a8f31e0a82dba8d8e
Autor:
Marcus J G W Ladds, Andrés Pastor-Fernández, Gergana Popova, Ingeborg M M van Leeuwen, Kai Er Eng, Catherine J Drummond, Lars Johansson, Richard Svensson, Nicholas J Westwood, Anna R McCarthy, Fredrik Tholander, Mihaela Popa, David P Lane, Emmet McCormack, Gerald M McInerney, Ravi Bhatia, Sonia Laín
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195956 (2018)
Tenovin-6 is the most studied member of a family of small molecules with antitumour activity in vivo. Previously, it has been determined that part of the effects of tenovin-6 associate with its ability to inhibit SirT1 and activate p53. However, teno
Externí odkaz:
https://doaj.org/article/0fd1ac03689f431cac754c84ca4df77d
Autor:
Anahi V Odell, Fanny Tran, Jenna E Foderaro, Séverine Poupart, Ravi Pathak, Nicholas J Westwood, Gary E Ward
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120331 (2015)
Differentiation of the protozoan parasite Toxoplasma gondii into its latent bradyzoite stage is a key event in the parasite's life cycle. Compound 2 is an imidazopyridine that was previously shown to inhibit the parasite lytic cycle, in part through
Externí odkaz:
https://doaj.org/article/f5e18c854501440ca62b7a9341e218c5
Autor:
Mariana Figuera-Losada, Marigo Stathis, Joelle M Dorskind, Ajit G Thomas, Veera Venkata Ratnam Bandaru, Seung-Wan Yoo, Nicholas J Westwood, Graeme W Rogers, Justin C McArthur, Norman J Haughey, Barbara S Slusher, Camilo Rojas
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0124481 (2015)
Ceramide is a bioactive lipid that plays an important role in stress responses leading to apoptosis, cell growth arrest and differentiation. Ceramide production is due in part to sphingomyelin hydrolysis by sphingomyelinases. In brain, neutral sphing
Externí odkaz:
https://doaj.org/article/222fdc4e88944241b91dbd2b6007f107
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98492 (2014)
The cytoskeletons of Toxoplasma gondii and related apicomplexan parasites are highly polarized, with apical and basal regions comprised of distinct protein complexes. Components of these complexes are known to play important roles in parasite shape,
Externí odkaz:
https://doaj.org/article/cfafc708c6954979af3dbd9a67c3baf0
Autor:
Inga Müller, Karin Larsson, Anna Frenzel, Ganna Oliynyk, Hanna Zirath, Edward V Prochownik, Nicholas J Westwood, Marie Arsenian Henriksson
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97285 (2014)
Members of the MYC family are the most frequently deregulated oncogenes in human cancer and are often correlated with aggressive disease and/or poorly differentiated tumors. Since patients with MYCN-amplified neuroblastoma have a poor prognosis, targ
Externí odkaz:
https://doaj.org/article/e9b2feb38afd4479b26ce8e7561a3577
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100450 (2014)
Toxoplasma gondii is a parasite of humans and animals, and a model for other apicomplexans including Plasmodium spp., the causative agents of malaria. Despite many advances, manipulating the T. gondii genome remains labor intensive, and is often rest
Externí odkaz:
https://doaj.org/article/f37cad6cae674a3fa293037c3661cb67
Autor:
Jacqueline M Leung, Fanny Tran, Ravindra B Pathak, Séverine Poupart, Aoife T Heaslip, Bryan A Ballif, Nicholas J Westwood, Gary E Ward
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98056 (2014)
Motility of the protozoan parasite Toxoplasma gondii plays an important role in the parasite's life cycle and virulence within animal and human hosts. Motility is driven by a myosin motor complex that is highly conserved across the Phylum Apicomplexa
Externí odkaz:
https://doaj.org/article/af31ed6079044f7fa3ec8bbf40edbf46
Autor:
Aoife T Heaslip, Jacqueline M Leung, Kimberly L Carey, Federica Catti, David M Warshaw, Nicholas J Westwood, Bryan A Ballif, Gary E Ward
Publikováno v:
PLoS Pathogens, Vol 6, Iss 1, p e1000720 (2010)
Toxoplasma gondii is an obligate intracellular parasite that enters cells by a process of active penetration. Host cell penetration and parasite motility are driven by a myosin motor complex consisting of four known proteins: TgMyoA, an unconventiona
Externí odkaz:
https://doaj.org/article/85cd29cf3d9b47debfa1081027c8a3b5
Autor:
Laura Elena Hofmann, Lisa-Marie Altmann, Oliver Fischer, Lea Prusko, Ganyuan Xiao, Nicholas J. Westwood, Markus R. Heinrich
Publikováno v:
ACS Omega, Vol 6, Iss 30, Pp 19400-19408 (2021)
Externí odkaz:
https://doaj.org/article/556fb441dd1347b49c5af61b3768dca0