Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Nicholas J Savill"'
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238781 (2020)
Maedi-visna (MV) is a complex lentiviral disease syndrome characterised by long immunological and clinical latencies and chronic progressive inflammatory pathology. Incurable at the individual level, it is widespread in most sheep-keeping countries,
Externí odkaz:
https://doaj.org/article/f98a8d1e62e84288880b50f16f8ff36b
Mitochondrial DNA is critical for longevity and metabolism of transmission stage Trypanosoma brucei.
Autor:
Caroline E Dewar, Paula MacGregor, Sinclair Cooper, Matthew K Gould, Keith R Matthews, Nicholas J Savill, Achim Schnaufer
Publikováno v:
PLoS Pathogens, Vol 14, Iss 7, p e1007195 (2018)
The sleeping sickness parasite Trypanosoma brucei has a complex life cycle, alternating between a mammalian host and the tsetse fly vector. A tightly controlled developmental programme ensures parasite transmission between hosts as well as survival w
Externí odkaz:
https://doaj.org/article/6bf39bc3042942c99171eaff26092736
Autor:
Kimberley F Prior, Daan R van der Veen, Aidan J O'Donnell, Katherine Cumnock, David Schneider, Arnab Pain, Amit Subudhi, Abhinay Ramaprasad, Samuel S C Rund, Nicholas J Savill, Sarah E Reece
Publikováno v:
PLoS Pathogens, Vol 14, Iss 2, p e1006900 (2018)
Circadian rhythms enable organisms to synchronise the processes underpinning survival and reproduction to anticipate daily changes in the external environment. Recent work shows that daily (circadian) rhythms also enable parasites to maximise fitness
Externí odkaz:
https://doaj.org/article/bdfcdfcc0fb04b8fb3d1251aa5bdfd5d
Autor:
Kate M Mitchell, Francisca Mutapi, Takafira Mduluza, Nicholas Midzi, Nicholas J Savill, Mark E J Woolhouse
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 7, p e3059 (2014)
Previous studies suggest that protective immunity against Schistosoma haematobium is primarily stimulated by antigens from dying worms. Praziquantel treatment kills adult worms, boosting antigen exposure and protective antibody levels. Current schist
Externí odkaz:
https://doaj.org/article/9aa3d121d3cc43de9b382414d4e137eb
Autor:
Zeenath U Islam, Stephen C Bishop, Nicholas J Savill, Raymond R R Rowland, Joan K Lunney, Benjamin Trible, Andrea B Doeschl-Wilson
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83567 (2013)
Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically significant viral diseases facing the global swine industry. Viremia profiles of PRRS virus challenged pigs reflect the severity and progression of infection within
Externí odkaz:
https://doaj.org/article/d51c5a6cd7e54c6abd168553eaadc3d9
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 10, p e1002237 (2011)
Urogenital schistosomiasis is a tropical disease infecting more than 100 million people in sub-Saharan Africa. Individuals in endemic areas endure repeated infections with long-lived schistosome worms, and also encounter larval and egg stages of the
Externí odkaz:
https://doaj.org/article/72bed2d5f0e243aea1c12c585a90392f
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 9 (2010)
Malarial infection is associated with complex immune and erythropoietic responses in the host. A quantitative understanding of these processes is essential to help inform malaria therapy and for the design of effective vaccines. In this study, we use
Externí odkaz:
https://doaj.org/article/9d7b360659fb42ad931ed89abfd8ec5b
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11185 (2010)
Various approaches have been used to investigate how properties of farm contact networks impact on the transmission of infectious diseases. The potential for transmission of an infection through a contact network can be evaluated in terms of the basi
Externí odkaz:
https://doaj.org/article/2b63c35e44544c0ca76de6f9b8cf2fc5
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 6, p e1000416 (2009)
Mathematical modelling has proven an important tool in elucidating and quantifying mechanisms that govern the age structure and population dynamics of red blood cells (RBCs). Here we synthesise ideas from previous experimental data and the mathematic
Externí odkaz:
https://doaj.org/article/8ba6a695fc84436b903c81d239b306fd
Autor:
Joshua Meehan, Suzanne M McDermott, Alasdair Ivens, Zachary Goodall, Zihao Chen, Zihao Yu, Jia Woo, Tyler Rodshagen, Laura McCleskey, Rebecca Sechrist, Kenneth Stuart, Lanying Zeng, Silvi Rouskin, Nicholas J Savill, Achim Schnaufer, Xiuren Zhang, Jorge Cruz-Reyes
Publikováno v:
Meehan, J, McDermott, S M, Ivens, A, Goodall, Z, Chen, Z, Yu, Z, Woo, J, Rodshagen, T, McCleskey, L, Seachrist, R, Stuart, K D, Zeng, L, Rouskin, S, Savill, N J, Schnaufer, A, Zhang, X & Cruz-Reyes, J 2023, ' Trypanosome RNA helicase KREH2 differentially controls noncanonical editing and putative repressive structure via a novel proposed “bifunctional” gRNA in mRNA A6 ', NAR Genomics and Bioinformatics . https://doi.org/10.1093/nar/gkad453
U-insertion/deletion (U-indel) RNA editing in trypanosome mitochondria is directed by guide RNAs (gRNAs). This editing may developmentally control respiration in bloodstream forms (BSF) and insect procyclic forms (PCF). Holo-editosomes include the ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b68bf9857675bb3b3d84828313abec39
https://www.pure.ed.ac.uk/ws/files/353452655/gkad453.pdf
https://www.pure.ed.ac.uk/ws/files/353452655/gkad453.pdf