Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nicholas J Mullen"'
Autor:
Nicholas J Mullen, Surendra K Shukla, Ravi Thakur, Sai Sundeep Kollala, Dezhen Wang, Nina Chaika, Juan F Santana, William R Miklavcic, Drew A LaBreck, Jayapal Reddy Mallareddy, David H Price, Amarnath Natarajan, Kamiya Mehla, David B Sykes, Michael A Hollingsworth, Pankaj K Singh
Publikováno v:
eLife, Vol 12 (2024)
Pyrimidine nucleotide biosynthesis is a druggable metabolic dependency of cancer cells, and chemotherapy agents targeting pyrimidine metabolism are the backbone of treatment for many cancers. Dihydroorotate dehydrogenase (DHODH) is an essential enzym
Externí odkaz:
https://doaj.org/article/3d1d4ecaa2d9414c902c7249254c6fee
Autor:
Nicholas J Mullen, David H Price
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186423 (2017)
Capping of nascent RNA polymerase II (Pol II) transcripts is required for gene expression and the first two steps are catalyzed by separate 5' triphosphatase and guanylyltransferase activities of the human capping enzyme (HCE). The cap is added co-tr
Externí odkaz:
https://doaj.org/article/9c9e23ae86e94cffb61b26539ac3ac80
Autor:
Nicholas J. Mullen, Pankaj K. Singh
Publikováno v:
Nature Reviews Cancer. 23:275-294
Autor:
Nicholas J. Mullen, Surendra K. Shukla, Ravi Thakur, Sai Sundeep Kollala, Dezhen Wang, Nina Chaika, Drew A. LaBreck, Jayapal Reddy Mallareddy, David H. Price, Amarnath Natarajan, Kamiya Mehla, David B. Sykes, Michael A. Hollingsworth, Pankaj K. Singh
Pyrimidine nucleotide biosynthesis is a druggable metabolic dependency of cancer cells, and chemotherapy agents targeting pyrimidine metabolism are the backbone of treatment for many cancers. Dihydroorotate dehydrogenase (DHODH) is an essential enzym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cff41bf800f0c643625c2fe3e28bd8e
https://doi.org/10.7554/elife.87292.1
https://doi.org/10.7554/elife.87292.1
Autor:
Clemens Steegborn, Chunbo He, Fang Yu, Antonello Mai, Kuldeep S. Attri, Sarika Chaudhary, Eric Verdin, Ping Lan, Tuo Hu, Sergio Valente, Surendra K. Shukla, Audrey J. Lazenby, Enza Vernucci, Ravi Thakur, David A. Tuveson, Divya Murthy, Xiao Fu, Nicholas J Mullen, Dante Rotili, Ryan J. King, Pankaj Singh, Dezhen Wang, Kamiya Mehla, Marco Tafani, Scott E. Mulder, Robin High, Kanupriya Jha, Johan Auwerx, Nina V. Chaika, Kasturi Siddhanta, Camila G. Pacheco
Publikováno v:
Gastroenterology
BACKGROUND & AIMS: SIRT5 plays pleiotropic roles via post-translational modifications, serving as a tumor suppressor, or an oncogene, in different tumors. However, the role SIRT5 plays in the initiation and progression of pancreatic ductal adenocarci
Autor:
Nicholas J. Mullen, Ravi Thakur, Surendra K. Shukla, Nina V. Chaika, Sai Sundeep Kollala, Dezhen Wang, Chunbo He, Yuki Fujii, Shikhar Sharma, Scott E. Mulder, David B. Sykes, Pankaj K. Singh
Publikováno v:
Cancer Lett
Inhibitors of dihydroorotate dehydrogenase (DHODH), a key enzyme for de novo synthesis of pyrimidine nucleotides, have failed in clinical trials for various cancers despite robust efficacy in preclinical animal models. To probe for druggable mediator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de3aeb07860a3c6c3320ebfc6d73474
https://europepmc.org/articles/PMC10305837/
https://europepmc.org/articles/PMC10305837/
Autor:
Fang Yu, Kelsey Klute, Kamiya Mehla, Ravi Thakur, Gavin Graves, Junichi Sadoshima, Rebecca E. Oberley-Deegan, Michael A. Hollingsworth, Divya Murthy, Camila G. Pacheco, Scott E. Mulder, Nina V. Chaika, Kuldeep S. Attri, Kyla Buettner, Melissa Teoh-Fitzgerald, Pankaj K. Singh, Jaime Abrego, Ibha Rai, Paul M. Grandgenett, Aneesha Dasgupta, Bradley N. Reames, Surendra K. Shukla, David A. Tuveson, Enza Vernucci, Nicholas J Mullen, Ryan J. King, Dezhen Wang, Michael Punsoni, Matthew C. Zimmerman, Dannielle D. Engle
Publikováno v:
The Journal of experimental medicine, vol 217, iss 7
The Journal of Experimental Medicine
The Journal of Experimental Medicine
This study demonstrates a novel signaling pathway regulating pancreatic cancer cachexia. These results establish that the Sirt1–Nox4 signaling axis plays an essential role in the manifestation of pancreatic cancer cachexia, and inhibition of this a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b95eacb1b84092379889e72b0d37e57c
https://escholarship.org/uc/item/1xf460n5
https://escholarship.org/uc/item/1xf460n5
Autor:
Kyle A. Nilson, Benjamin M Spector, David H. Price, Jeffery L. Meier, Christopher B. Ball, Christine K. Lawson, Nicholas J. Mullen
Publikováno v:
Nucleic Acids Research
Oxidative stress has pervasive effects on cells but how they respond transcriptionally upon the initial insult is incompletely understood. We developed a nuclear walk-on assay that semi-globally quantifies nascent transcripts in promoter-proximal pau
Autor:
Morshed Alam, Lyudmyla Berim, Kelsey Klute, Mridula Krishnan, Ferdinand Osayande, Lei Yu, Aneesha Dasgupta, Pankaj K. Singh, Fang Yu, Nicholas J Mullen, Jennifer M. Oliveto
Publikováno v:
Journal of Clinical Oncology. 37:e15716-e15716
e15716 Background: The incidence of pancreatic ductal adenocarcinoma (PDAC) is on the rise and continues to have a poor overall survival despite aggressive available treatment strategies. Sarcopenia is prevalent in PDAC patients and is likely caused