Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Nicholas J Matheson"'
Autor:
Jarrod Shilts, Thomas W M Crozier, Ana Teixeira-Silva, Ildar Gabaev, Pehuén Pereyra Gerber, Edward J D Greenwood, Samuel James Watson, Brian M Ortmann, Christian M Gawden-Bone, Tekle Pauzaite, Markus Hoffmann, James A Nathan, Stefan Pöhlmann, Nicholas J Matheson, Paul J Lehner, Gavin J Wright
Publikováno v:
PLoS Biology, Vol 21, Iss 2, p e3001959 (2023)
The interactions between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and human host factors enable the virus to propagate infections that lead to Coronavirus Disease 2019 (COVID-19). The spike protein is the largest structural compon
Externí odkaz:
https://doaj.org/article/b29561a147434b44ba62633c5cedb4fe
Autor:
Pehuén Pereyra Gerber, Lidia M Duncan, Edward Jd Greenwood, Sara Marelli, Adi Naamati, Ana Teixeira-Silva, Thomas Wm Crozier, Ildar Gabaev, Jun R Zhan, Thomas E Mulroney, Emily C Horner, Rainer Doffinger, Anne E Willis, James Ed Thaventhiran, Anna V Protasio, Nicholas J Matheson
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010265 (2022)
Efforts to define serological correlates of protection against COVID-19 have been hampered by the lack of a simple, scalable, standardised assay for SARS-CoV-2 infection and antibody neutralisation. Plaque assays remain the gold standard, but are imp
Externí odkaz:
https://doaj.org/article/fc58511d567e4f39b8fc1cbccd1ce0b6
Autor:
Mark Ferris, Rebecca Ferris, Chris Workman, Eoin O'Connor, David A Enoch, Emma Goldesgeyme, Natalie Quinnell, Parth Patel, Jo Wright, Geraldine Martell, Christine Moody, Ashley Shaw, Christopher JR Illingworth, Nicholas J Matheson, Michael P Weekes
Publikováno v:
eLife, Vol 10 (2021)
Background: Respiratory protective equipment recommended in the UK for healthcare workers (HCWs) caring for patients with COVID-19 comprises a fluid-resistant surgical mask (FRSM), except in the context of aerosol generating procedures (AGPs). We pre
Externí odkaz:
https://doaj.org/article/63fe9434a49f45088ced810afef01798
Autor:
Luca Peruzzotti-Jametti, Joshua D Bernstock, Cory M Willis, Giulia Manferrari, Rebecca Rogall, Erika Fernandez-Vizarra, James C Williamson, Alice Braga, Aletta van den Bosch, Tommaso Leonardi, Grzegorz Krzak, Ágnes Kittel, Cristiane Benincá, Nunzio Vicario, Sisareuth Tan, Carlos Bastos, Iacopo Bicci, Nunzio Iraci, Jayden A Smith, Ben Peacock, Karin H Muller, Paul J Lehner, Edit Iren Buzas, Nuno Faria, Massimo Zeviani, Christian Frezza, Alain Brisson, Nicholas J Matheson, Carlo Viscomi, Stefano Pluchino
Publikováno v:
PLoS Biology, Vol 19, Iss 4, p e3001166 (2021)
Neural stem cell (NSC) transplantation induces recovery in animal models of central nervous system (CNS) diseases. Although the replacement of lost endogenous cells was originally proposed as the primary healing mechanism of NSC grafts, it is now cle
Externí odkaz:
https://doaj.org/article/62e32062ab904101a16fc0e8ef20d45c
Autor:
Nick K Jones, Lucy Rivett, Shaun Seaman, Richard J Samworth, Ben Warne, Chris Workman, Mark Ferris, Jo Wright, Natalie Quinnell, Ashley Shaw, Cambridge COVID-19 Collaboration, Ian G Goodfellow, Paul J Lehner, Rob Howes, Giles Wright, Nicholas J Matheson, Michael P Weekes
Publikováno v:
eLife, Vol 10 (2021)
The BNT162b2 mRNA COVID-19 vaccine (Pfizer-BioNTech) is being utilised internationally for mass COVID-19 vaccination. Evidence of single-dose protection against symptomatic disease has encouraged some countries to opt for delayed booster doses of BNT
Externí odkaz:
https://doaj.org/article/f18c801589924864962d116dea1c1740
Autor:
Darrel P Francis, Michael Brown, Nicholas J Matheson, Grant D Stewart, Jane Greenaway, Nick G Cunniffe, Simon J Gunter, Sarah W Burge, Tom Dymond, Hanif Esmail, Jacqui Galloway, Effrossyni Gkrania-Klotsas, George Katritsis, Martin D Knolle, Kelly Leonard, Zoe C McIntyre, Ben Prudon, Tommy Rampling, Mili Estee Torok, Ben Warne, Mark Yates, Sofia Villar
Publikováno v:
BMJ Open, Vol 10, Iss 10 (2020)
Objectives To analyse enrolment to interventional trials during the first wave of the COVID-19 pandemic in England and describe the barriers to successful recruitment in the circumstance of a further wave or future pandemics.Design We analysed regist
Externí odkaz:
https://doaj.org/article/9aa77797e2424303a05fbcb0e47a38f3
Autor:
Allison N Lau, Zhaoqi Li, Laura V Danai, Anna M Westermark, Alicia M Darnell, Raphael Ferreira, Vasilena Gocheva, Sharanya Sivanand, Evan C Lien, Kiera M Sapp, Jared R Mayers, Giulia Biffi, Christopher R Chin, Shawn M Davidson, David A Tuveson, Tyler Jacks, Nicholas J Matheson, Omer Yilmaz, Matthew G Vander Heiden
Publikováno v:
eLife, Vol 9 (2020)
Tumors are composed of many different cell types including cancer cells, fibroblasts, and immune cells. Dissecting functional metabolic differences between cell types within a mixed population can be challenging due to the rapid turnover of metabolit
Externí odkaz:
https://doaj.org/article/d77eaf4877714df6a00d2b9f769cb0f8
Autor:
Nick K Jones, Lucy Rivett, Dominic Sparkes, Sally Forrest, Sushmita Sridhar, Jamie Young, Joana Pereira-Dias, Claire Cormie, Harmeet Gill, Nicola Reynolds, Michelle Wantoch, Matthew Routledge, Ben Warne, Jack Levy, William David Córdova Jiménez, Fathima Nisha Begum Samad, Chris McNicholas, Mark Ferris, Jane Gray, Michael Gill, The CITIID-NIHR COVID-19 BioResource Collaboration, Martin D Curran, Stewart Fuller, Afzal Chaudhry, Ashley Shaw, John R Bradley, Gregory J Hannon, Ian G Goodfellow, Gordon Dougan, Kenneth GC Smith, Paul J Lehner, Giles Wright, Nicholas J Matheson, Stephen Baker, Michael P Weekes
Publikováno v:
eLife, Vol 9 (2020)
Previously, we showed that 3% (31/1032)of asymptomatic healthcare workers (HCWs) from a large teaching hospital in Cambridge, UK, tested positive for SARS-CoV-2 in April 2020. About 15% (26/169) HCWs with symptoms of coronavirus disease 2019 (COVID-1
Externí odkaz:
https://doaj.org/article/23a09a039e26435589faa0bbe36f41e4
Autor:
Lucy Rivett, Sushmita Sridhar, Dominic Sparkes, Matthew Routledge, Nick K Jones, Sally Forrest, Jamie Young, Joana Pereira-Dias, William L Hamilton, Mark Ferris, M Estee Torok, Luke Meredith, The CITIID-NIHR COVID-19 BioResource Collaboration, Martin D Curran, Stewart Fuller, Afzal Chaudhry, Ashley Shaw, Richard J Samworth, John R Bradley, Gordon Dougan, Kenneth GC Smith, Paul J Lehner, Nicholas J Matheson, Giles Wright, Ian G Goodfellow, Stephen Baker, Michael P Weekes
Publikováno v:
eLife, Vol 9 (2020)
Significant differences exist in the availability of healthcare worker (HCW) SARS-CoV-2 testing between countries, and existing programmes focus on screening symptomatic rather than asymptomatic staff. Over a 3 week period (April 2020), 1032 asymptom
Externí odkaz:
https://doaj.org/article/cc538b51221c425e9c7cee66c061f849
Autor:
Sara Marelli, James C Williamson, Anna V Protasio, Adi Naamati, Edward JD Greenwood, Janet E Deane, Paul J Lehner, Nicholas J Matheson
Publikováno v:
eLife, Vol 9 (2020)
The seminal description of the cellular restriction factor APOBEC3G and its antagonism by HIV-1 Vif has underpinned two decades of research on the host-virus interaction. We recently reported that HIV-1 Vif is also able to degrade the PPP2R5 family o
Externí odkaz:
https://doaj.org/article/207cba6cd24e44cfbd68b5a7f96b6775