Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Nicholas J Maragakis"'
Autor:
Daniel N. Candrea, Samyak Shah, Shiyu Luo, Miguel Angrick, Qinwan Rabbani, Christopher Coogan, Griffin W. Milsap, Kevin C. Nathan, Brock A. Wester, William S. Anderson, Kathryn R. Rosenblatt, Alpa Uchil, Lora Clawson, Nicholas J. Maragakis, Mariska J. Vansteensel, Francesco V. Tenore, Nicolas F. Ramsey, Matthew S. Fifer, Nathan E. Crone
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-14 (2024)
Abstract Background Brain-computer interfaces (BCIs) can restore communication for movement- and/or speech-impaired individuals by enabling neural control of computer typing applications. Single command click detectors provide a basic yet highly func
Externí odkaz:
https://doaj.org/article/5c5b61fc56574dd6b4b5cc7132cd8687
Autor:
Ying Li, Umamahesw Balasubramanian, Devon Cohen, Ping-Wu Zhang, Elizabeth Mosmiller, Rita Sattler, Nicholas J Maragakis, Jeffrey D Rothstein
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118266 (2015)
Amyotrophic lateral sclerosis is a progressive disease characterized by the loss of upper and lower motor neurons, leading to paralysis of voluntary muscles. About 10% of all ALS cases are familial (fALS), among which 15-20% are linked to Cu/Zn super
Externí odkaz:
https://doaj.org/article/b3dc871e53744e85a896f5a6bfef469c
Publikováno v:
Neurobiology of Disease, Vol 15, Iss 3, Pp 461-473 (2004)
Glutamate is the primary excitatory amino acid neurotransmitter in the central nervous system and its activity is carefully modulated in the synaptic cleft by glutamate transporters. A number of glutamate transporters have been identified in the cent
Externí odkaz:
https://doaj.org/article/0f9ccccae945435fa354fe30cf0b6f82
Autor:
Jacob J. Adashek, Chinmayi Pandya, Nicholas J. Maragakis, Pradip De, Philip R. Cohen, Shumei Kato, Razelle Kurzrock
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Neuregulin-1 (NRG1) is implicated in both cancer and neurologic diseases such as amyotrophic lateral sclerosis (ALS); however, to date, there has been little cross-field discussion between neurology and oncology in regard to these
Externí odkaz:
https://doaj.org/article/5510840f22664d2da2e8c1900f898037
Autor:
Selina Wray, Matthew Self, NINDS Parkinson's Disease iPSC Consortium, NINDS Huntington's Disease iPSC Consortium, NINDS ALS iPSC Consortium, Patrick A Lewis, Jan-Willem Taanman, Natalie S Ryan, Colin J Mahoney, Yuying Liang, Michael J Devine, Una-Marie Sheerin, Henry Houlden, Huw R Morris, Daniel Healy, Jose-Felix Marti-Masso, Elisavet Preza, Suzanne Barker, Margaret Sutherland, Roderick A Corriveau, Michael D'Andrea, Anthony H V Schapira, Ryan J Uitti, Mark Guttman, Grzegorz Opala, Barbara Jasinska-Myga, Andreas Puschmann, Christer Nilsson, Alberto J Espay, Jaroslaw Slawek, Ludwig Gutmann, Bradley F Boeve, Kevin Boylan, A Jon Stoessl, Owen A Ross, Nicholas J Maragakis, Jay Van Gerpen, Melissa Gerstenhaber, Katrina Gwinn, Ted M Dawson, Ole Isacson, Karen S Marder, Lorraine N Clark, Serge E Przedborski, Steven Finkbeiner, Jeffrey D Rothstein, Zbigniew K Wszolek, Martin N Rossor, John Hardy
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43099 (2012)
Our understanding of the molecular mechanisms of many neurological disorders has been greatly enhanced by the discovery of mutations in genes linked to familial forms of these diseases. These have facilitated the generation of cell and animal models
Externí odkaz:
https://doaj.org/article/9a35e1d7ec9b460c9b9c8d8637a681ec
Autor:
Angelo C Lepore, John O'Donnell, Andrew S Kim, Timothy Williams, Alicia Tuteja, Mahendra S Rao, Linda L Kelley, James T Campanelli, Nicholas J Maragakis
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25968 (2011)
Cellular abnormalities are not limited to motor neurons in amyotrophic lateral sclerosis (ALS). There are numerous observations of astrocyte dysfunction in both humans with ALS and in SOD1(G93A) rodents, a widely studied ALS model. The present study
Externí odkaz:
https://doaj.org/article/3eee2f357dbc4a45a5b0a7dab7ea8636
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 11, Pp 1948-1971 (2023)
Abstract Numerous potential amyotrophic lateral sclerosis (ALS)‐relevant pathways have been hypothesized and studied preclinically, with subsequent translation to clinical trial. However, few successes have been observed with only modest effects. A
Externí odkaz:
https://doaj.org/article/52e8784194e74b53852a7df68858947f
Autor:
Shiyu Luo, Miguel Angrick, Christopher Coogan, Daniel N. Candrea, Kimberley Wyse‐Sookoo, Samyak Shah, Qinwan Rabbani, Griffin W. Milsap, Alexander R. Weiss, William S. Anderson, Donna C. Tippett, Nicholas J. Maragakis, Lora L. Clawson, Mariska J. Vansteensel, Brock A. Wester, Francesco V. Tenore, Hynek Hermansky, Matthew S. Fifer, Nick F. Ramsey, Nathan E. Crone
Publikováno v:
Advanced Science, Vol 10, Iss 35, Pp n/a-n/a (2023)
Abstract Brain‐computer interfaces (BCIs) can be used to control assistive devices by patients with neurological disorders like amyotrophic lateral sclerosis (ALS) that limit speech and movement. For assistive control, it is desirable for BCI syste
Externí odkaz:
https://doaj.org/article/c2b5c3fff5c442deab0c55d497c7f907
Autor:
Katherine L. Marshall, Labchan Rajbhandari, Arun Venkatesan, Nicholas J. Maragakis, Mohamed H. Farah
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, characterized by degeneration of upper and lower motor neurons that leads to muscle weakness, paralysis, and death, but the effects of disease-causing mutations
Externí odkaz:
https://doaj.org/article/618425bc3da44c26b14ec76b7174e164
Autor:
Jeremy M. Shefner, Ammar Al-Chalabi, Jinsy A. Andrews, Adriano Chio, Mamede De Carvalho, Bettina M. Cockroft, Philippe Corcia, Philippe Couratier, Merit E. Cudkowicz, Angela Genge, Orla Hardiman, Terry Heiman-Patterson, Robert D. Henderson, Caroline Ingre, Carlayne E. Jackson, Wendy Johnston, Noah Lechtzin, Albert Ludolph, Nicholas J. Maragakis, Timothy M. Miller, Jesus S. Mora Pardina, Susanne Petri, Zachary Simmons, Leonard H. Van Den Berg, Lorne Zinman, Stuart Kupfer, Fady I. Malik, Lisa Meng, Tyrell J. Simkins, Jenny Wei, Andrew A. Wolff, Stacy A. Rudnicki
Publikováno v:
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. :1-12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d31cd2d7e9ffeb1257d9c346e24b616e
https://doi.org/10.1080/21678421.2023.2216223
https://doi.org/10.1080/21678421.2023.2216223