Výsledky vyhledávání - "Nicholas J Izzo"

Akademický článek

Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits.

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e111898 (2014)

Synaptic dysfunction and loss caused by age-dependent accumulation of synaptotoxic beta amyloid (Abeta) 1-42 oligomers is proposed to underlie cognitive decline in Alzheimer's disease (AD). Alterations in membrane trafficking induced by Abeta oligome

Externí odkaz: https://doaj.org/article/7588522c8af84352a18c72ff5aa5c7b2

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Akademický článek

Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity.

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e111899 (2014)

Amyloid beta (Abeta) 1-42 oligomers accumulate in brains of patients with Mild Cognitive Impairment (MCI) and disrupt synaptic plasticity processes that underlie memory formation. Synaptic binding of Abeta oligomers to several putative receptor prote

Externí odkaz: https://doaj.org/article/b30b103a4849402a9db579ed34d6a602

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Exploration of Diazaspiro Cores as Piperazine Bioisosteres in the Development of σ2 Receptor Ligands

Autor: Kuiying Xu, Chia-Ju Hsieh, Ji Youn Lee, Aladdin Riad, Nicholas J. Izzo, Gary Look, Susan Catalano, Robert H. Mach

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8259

A series of σ2R compounds containing benzimidazolone and diazacycloalkane cores was synthesized and evaluated in radioligand binding assays. Replacing the piperazine moiety in a lead compound with diazaspiroalkanes and the fused octahydropyrrolo[3,4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de5680c9e363ec19c3952e34f23507f4
https://pubmed.ncbi.nlm.nih.gov/35897835

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Screening of σ

Autor: Ho Young, Kim, Ji Youn, Lee, Chia-Ju, Hsieh, Aladdin, Riad, Nicholas J, Izzo, Susan M, Catalano, Thomas J A, Graham, Robert H, Mach

Publikováno v: Journal of medicinal chemistry. 65(8)

In this study, a panel of 46 compounds containing five different scaffolds known to have high σ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7a825dc3de6ddeedbbeb47aba3a7760e
https://pubmed.ncbi.nlm.nih.gov/35404616

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Alzheimer’s protection effect of A673T mutation may be driven by lower Aβ oligomer binding affinity

Autor: Hank Safferstein, Kelsey Sadlek, Raymond Yurko, Kelsie Mozzoni, Courtney Rehak, Nicholas J. Izzo, Susan M. Catalano, Harry LeVine, Colleen S. Limegrover

Publikováno v: Journal of Neurochemistry

Several mutations conferring protection against Alzheimer's disease (AD) have been described, none as profound as the A673T mutation, where carriers are four times less likely to get AD compared to noncarriers. This mutation results in reduced amyloi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c42aa939f20295bfdf92fbf8ea75fcd6
http://europepmc.org/articles/PMC8246829

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Discovery of Investigational Drug CT1812, an Antagonist of the Sigma-2 Receptor Complex for Alzheimer’s Disease

Autor: Kelsie M. LaBarbera, Yingcai Wang, Nicholas J. Izzo, Yaodong Huang, Zhi-Jie Ni, Courtney Rehak, Gilbert M. Rishton, Gary C. Look, Raymond Yurko, Colleen S. Limegrover, Jason Zhang, Susan M. Catalano, Xiaodong Wu

Publikováno v: ACS Med Chem Lett

[Image: see text] An unbiased phenotypic neuronal assay was developed to measure the synaptotoxic effects of soluble Aβ oligomers. A collection of CNS druglike small molecules prepared by conditioned extraction was screened. Compounds that prevented

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb7d609a044f4759fd8fa7433e74dda
https://europepmc.org/articles/PMC8436239/

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A phase 1 clinical trial of the sigma‐2 receptor complex allosteric antagonist CT1812, a novel therapeutic candidate for Alzheimer's disease

Autor: Susan M. Catalano, Hank Safferstein, Michael Grundman, Roger Morgan, Julie Pribyl, Kelsie Mozzoni, Steven T. DeKosky, Jason D. Lickliter, Michelle Higgin, Lon S. Schneider, Robert Guttendorf, Nicholas J. Izzo

Publikováno v: Alzheimer's & Dementia : Translational Research & Clinical Interventions

Background Elayta (CT1812) is a novel allosteric antagonist of the sigma-2 receptor complex that prevents and displaces binding of Aβ oligomers to neurons. By stopping a key initiating event in Alzheimer's disease, this first-in–class drug candida

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62cf8079e5cf92f7fa5c76ca49864bc5
https://doi.org/10.1016/j.trci.2018.11.001

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TMEM97 increases in synapses and is a potential synaptic Aβ binding partner in human Alzheimer’s disease

Autor: Tara L. Spires-Jones, Monique Hooley, Colin Smith, Anton-Fernandez A, Jamie Rose, Susan M. Catalano, Makis Tzioras, Rosemary J. Jackson, J. H. Catterson, Nicholas J. Izzo, Claire L. Davies, Tempelaar R, Martí Colom-Cadena, Jane Tulloch, Sophie Dunnett

Synapse loss correlates with cognitive decline in Alzheimer’s disease (AD), and soluble amyloid beta (Aβ) is implicated in synaptic dysfunction and loss. An important knowledge gap is the lack of understanding of how synaptic accumulation of Aβ l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed92cd0edcf16138aa25188d4a80a123
https://doi.org/10.1101/2021.02.01.428238

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