Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nicholas J Fuda"'
Autor:
Nicholas J Fuda, Michael J Guertin, Sumeet Sharma, Charles G Danko, André L Martins, Adam Siepel, John T Lis
Publikováno v:
PLoS Genetics, Vol 11, Iss 3, p e1005108 (2015)
Previous studies have shown that GAGA Factor (GAF) is enriched on promoters with paused RNA Polymerase II (Pol II), but its genome-wide function and mechanism of action remain largely uncharacterized. We assayed the levels of transcriptionally-engage
Externí odkaz:
https://doaj.org/article/ee4a1cac549c42cc80ed481117a2c9f7
Autor:
Byron C Williams, Joshua J Filter, Kristina A Blake-Hodek, Brian E Wadzinski, Nicholas J Fuda, David Shalloway, Michael L Goldberg
Publikováno v:
eLife, Vol 3 (2014)
During M phase, Endosulfine (Endos) family proteins are phosphorylated by Greatwall kinase (Gwl), and the resultant pEndos inhibits the phosphatase PP2A-B55, which would otherwise prematurely reverse many CDK-driven phosphorylations. We show here tha
Externí odkaz:
https://doaj.org/article/cbc61139874c4097b350db9fa5c17e5d
Autor:
Nicholas J. Fuda, Katjuša Brejc, William S. Kruesi, Edward J. Ralston, Rachel Bigley, Aram Shin, Miki Okada, Barbara J. Meyer
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Organisms that count X-chromosome number to determine sex utilize dosage compensation mechanisms to balance X-gene expression between sexes. Typically, a regulatory complex is recruited to X chromosomes of one sex to modulate gene expression. A major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96516524fc59f629a48660c8f5981503
https://doi.org/10.1073/pnas.2211642119
https://doi.org/10.1073/pnas.2211642119
Autor:
Leighton J. Core, Fabiana M. Duarte, Nicholas J. Fuda, Dig Bijay Mahat, Michael J. Guertin, John T. Lis
The coordinated regulation of gene expression at the transcriptional level is fundamental to organismal development and homeostasis. Inducible systems are invaluable when studying transcription because the regulatory process can be triggered instanta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07bb1aaec612976fcf16ace9b908e8c8
https://doi.org/10.1101/055921
https://doi.org/10.1101/055921
Autor:
Bartlomiej Bartkowiak, Hemali Phatnani, David H. Price, Nicholas J. Fuda, Arno L. Greenleaf, John T. Lis, Pengda Liu, Karen Adelman, Jeffrey J. Cooper
Publikováno v:
Genes & Development. 24:2303-2316
The C-terminal repeat domain (CTD) of RNA polymerase II (RNAPII) is an intrinsically unstructured extension of the enzyme's largest subunit, RPB1. The CTD is composed of a tandem array of seven amino acid repeats with the consensus sequence Y1S2P3T4S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b284bee162ea98a3f142717cd599080
https://doi.org/10.1101/gad.1968210
https://doi.org/10.1101/gad.1968210
Autor:
Jie Yao, Steven J. Petesch, Watt W. Webb, John T. Lis, Karen Adelman, Nicholas J. Fuda, M. Behfar Ardehali
Publikováno v:
The EMBO Journal. 28:1067-1077
Several eukaryotic transcription factors have been shown to modulate the elongation rate of RNA polymerase II (Pol II) on naked or chromatin-reconstituted templates in vitro. However, none of the tested factors have been shown to directly affect the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1714fab6cfc18b1d4b749da10fe96a
https://doi.org/10.1038/emboj.2009.56
https://doi.org/10.1038/emboj.2009.56
Autor:
Sumeet Sharma, John T. Lis, André L. Martins, Nicholas J. Fuda, Adam Siepel, Charles G. Danko, Michael J. Guertin
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 11, Iss 3, p e1005108 (2015)
PLoS Genetics, Vol 11, Iss 3, p e1005108 (2015)
Previous studies have shown that GAGA Factor (GAF) is enriched on promoters with paused RNA Polymerase II (Pol II), but its genome-wide function and mechanism of action remain largely uncharacterized. We assayed the levels of transcriptionally-engage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd92f2a4556d3ae19fa980c6afd10f8b
http://europepmc.org/articles/PMC4376892
http://europepmc.org/articles/PMC4376892
Publikováno v:
Journal of Experimental Biology. 206:2031-2038
SUMMARY In Drosophila flight muscles, glycolytic enzymes are co-localized along sarcomeres at M-lines and Z-discs and co-localization is required for normal flight. We have extended our analysis of this phenomenon to include a set of six glycolytic e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4336ef11153c72a6f81375459c220972
https://doi.org/10.1242/jeb.00367
https://doi.org/10.1242/jeb.00367
Autor:
Brian E. Wadzinski, Joshua J Filter, Nicholas J. Fuda, David Shalloway, Kristina A. Blake-Hodek, Michael L. Goldberg, Byron C. Williams
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c55662fcc4b43ff4018a9bb2b582fe2
https://doi.org/10.7554/elife.01695.026
https://doi.org/10.7554/elife.01695.026
Autor:
Nicholas J. Fuda, John T. Lis
Thousands of genes in Drosophila have Pol II paused in the promoter proximal region. Almost half of these genes are associated with either GAGA factor (GAF) or a newly discovered factor we call M1BP. Although both factors dictate the association of P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039e4433ff95feeef6a4ff14960dbb4a
https://europepmc.org/articles/PMC3981171/
https://europepmc.org/articles/PMC3981171/