Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Nicholas J Clemons"'
Autor:
Francesc de Las Heras, Camilla B Mitchell, William K Murray, Nicholas J Clemons, Wayne A Phillips
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0308051 (2024)
Preclinical models that replicate patient tumours as closely as possible are crucial for translational cancer research. While in vitro cancer models have many advantages in assessing tumour response therapy, in vivo systems are essential to enable ev
Externí odkaz:
https://doaj.org/article/aad2ee58456447df8453555b80848898
Autor:
Sophia Ceder, Sofi E Eriksson, Emarndeena H Cheteh, Swati Dawar, Mariana Corrales Benitez, Vladimir J N Bykov, Kenji M Fujihara, Mélodie Grandin, Xiaodun Li, Susanne Ramm, Corina Behrenbruch, Kaylene J Simpson, Frédéric Hollande, Lars Abrahmsen, Nicholas J Clemons, Klas G Wiman
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 2, Pp 1-20 (2020)
Abstract The tumor suppressor gene TP53 is the most frequently mutated gene in cancer. The compound APR‐246 (PRIMA‐1Met/Eprenetapopt) is converted to methylene quinuclidinone (MQ) that targets mutant p53 protein and perturbs cellular antioxidant
Externí odkaz:
https://doaj.org/article/ad163b956af24ac198adeee8afcb4f6a
Autor:
Yilin Kang, Alexander J Anderson, Thomas Daniel Jackson, Catherine S Palmer, David P De Souza, Kenji M Fujihara, Tegan Stait, Ann E Frazier, Nicholas J Clemons, Deidreia Tull, David R Thorburn, Malcolm J McConville, Michael T Ryan, David A Stroud, Diana Stojanovski
Publikováno v:
eLife, Vol 9 (2020)
Externí odkaz:
https://doaj.org/article/2d1831cdc40a485f949b44ba981fa33e
Autor:
Yilin Kang, Alexander J Anderson, Thomas Daniel Jackson, Catherine S Palmer, David P De Souza, Kenji M Fujihara, Tegan Stait, Ann E Frazier, Nicholas J Clemons, Deidreia Tull, David R Thorburn, Malcolm J McConville, Michael T Ryan, David A Stroud, Diana Stojanovski
Publikováno v:
eLife, Vol 8 (2019)
Human Tim8a and Tim8b are members of an intermembrane space chaperone network, known as the small TIM family. Mutations in TIMM8A cause a neurodegenerative disease, Mohr-Tranebjærg syndrome (MTS), which is characterised by sensorineural hearing loss
Externí odkaz:
https://doaj.org/article/4f02d9ebb07446aaa3658ebabded353b
Autor:
Carlos S. Cabalag, Owen W. J. Prall, John Ciciulla, Laurence A. Galea, Niko Thio, Madawa Jayawardana, Trishe Y. M. Leong, Julia V. Milne, Kenji M. Fujihara, Lynn Chong, Michael W. Hii, Gisela Mir Arnau, Paul J. Neeson, Wayne A. Phillips, Cuong P. Duong, Nicholas J. Clemons
Publikováno v:
Annals of Surgical Oncology. 30:1614-1625
Background In esophageal cancer (EC), there is a paucity of knowledge regarding the interplay between the tumor immune microenvironment and response to neoadjuvant treatment and, therefore, which factors may influence outcomes. Thus, our goal was to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::935613760b2860f468023539fcb53bff
https://doi.org/10.1245/s10434-022-12562-5
https://doi.org/10.1245/s10434-022-12562-5
Autor:
Nicholas J. Clemons, Wayne A. Phillips, Sue Haupt, Lara Lipton, Ygal Haupt, Kaylene J. Simpson, David S. Liu, Hyun S. Ko, Bonnie Z. Zhang, Carlos S. Cabalag, Mariana Corrales Benitez, Kenji M. Fujihara
Gene List from siRNA screen with APR-246 growth inhibition in H1299 p53-null (Sheet 1) and p53-R273H (Sheet 2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090f47a97b900f2bb86472fce1849758
https://doi.org/10.1158/1535-7163.22521225.v1
https://doi.org/10.1158/1535-7163.22521225.v1
Autor:
Nicholas J. Clemons, Wayne A. Phillips, Sue Haupt, Lara Lipton, Ygal Haupt, Kaylene J. Simpson, David S. Liu, Hyun S. Ko, Bonnie Z. Zhang, Carlos S. Cabalag, Mariana Corrales Benitez, Kenji M. Fujihara
Figure S5 shows MYC directly regulates SLC7A11 levels and APR-246 sensitivity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086b5d7a6ec3a0564436c375e3b496a4
https://doi.org/10.1158/1535-7163.22521228.v1
https://doi.org/10.1158/1535-7163.22521228.v1
Autor:
Nicholas J. Clemons, Wayne A. Phillips, Sue Haupt, Lara Lipton, Ygal Haupt, Kaylene J. Simpson, David S. Liu, Hyun S. Ko, Bonnie Z. Zhang, Carlos S. Cabalag, Mariana Corrales Benitez, Kenji M. Fujihara
Supplemental Table 1, 2, 3. Supplemental Materials and Methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0845899ac93972a66af316cec63330
https://doi.org/10.1158/1535-7163.22521222
https://doi.org/10.1158/1535-7163.22521222
Autor:
Ian Y. Luk, Laura J. Jenkins, Kael L. Schoffer, Irvin Ng, Janson W. T. Tse, Dmitri Mouradov, Stanislaw Kaczmarczyk, Rebecca Nightingale, Allan D. Burrows, Robin L. Anderson, Diego Arango, Higinio Dopeso, Larry Croft, Mark F. Richardson, Oliver M. Sieber, Yang Liao, Jennifer K. Mooi, Natalia Vukelic, Camilla M. Reehorst, Shoukat Afshar-Sterle, Vicki L. J. Whitehall, Lochlan Fennell, Helen E. Abud, Niall C. Tebbutt, Wayne A. Phillips, David S. Williams, Wei Shi, Lisa A. Mielke, Matthias Ernst, Amardeep S. Dhillon, Nicholas J. Clemons, John M. Mariadason
Publikováno v:
Scientia
Epigenetics; Tumour-suppressor proteins Epigenética; Proteínas supresoras de tumores Epigenètica; Proteïnes supresores de tumors Colorectal cancers (CRCs) often display histological features indicative of aberrant differentiation but the molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c1771def1a2b343893e5c103bb2bd76
Autor:
Carlos S. Cabalag, Owen W. J. Prall, John Ciciulla, Laurence A. Galea, Niko Thio, Madawa Jayawardana, Trishe Y. M. Leong, Julia V. Milne, Kenji M. Fujihara, Lynn Chong, Michael W. Hii, Gisela Mir Arnau, Paul J. Neeson, Wayne A. Phillips, Cuong P. Duong, Nicholas J. Clemons
Publikováno v:
Annals of surgical oncology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac04fb8df80b9876ca17a64813ad969
https://pubmed.ncbi.nlm.nih.gov/36219279
https://pubmed.ncbi.nlm.nih.gov/36219279