Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nicholas J Catanzaro"'
Autor:
John N Snouwaert, Leigh A Jania, Trang Nguyen, David R Martinez, Alexandra Schäfer, Nicholas J Catanzaro, Kendra L Gully, Ralph S Baric, Mark Heise, Martin T Ferris, Elizabeth Anderson, Katia Pressey, Jacob A Dillard, Sharon Taft-Benz, Victoria K Baxter, Jenny P-Y Ting, Beverly H Koller
Publikováno v:
PLoS Pathogens, Vol 19, Iss 2, p e1011168 (2023)
Angiotensin-converting enzyme 2 (ACE2), part of the renin-angiotensin system (RAS), serves as an entry point for SARS-CoV-2, leading to viral proliferation in permissive cell types. Using mouse lines in which the Ace2 locus has been humanized by synt
Externí odkaz:
https://doaj.org/article/75be0b479d294111a5b725cdfbedb42c
Autor:
David R. Martinez, Alexandra Schaefer, Tyler D. Gavitt, Michael L. Mallory, Esther Lee, Nicholas J. Catanzaro, Haiyan Chen, Kendra Gully, Trevor Scobey, Pooja Korategere, Alecia Brown, Lena Smith, Rob Parks, Maggie Barr, Amanda Newman, Cindy Bowman, John M. Powers, Katayoun Mansouri, Robert J. Edwards, Ralph S. Baric, Barton F. Haynes, Kevin O. Saunders
Publikováno v:
bioRxiv
SUMMARYThe emergence of three distinct highly pathogenic human coronaviruses – SARS-CoV in 2003, MERS-CoV in 2012, and SARS-CoV-2 in 2019 – underlines the need to develop broadly active vaccines against theMerbecovirusandSarbecovirusbetacoronavir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b315c72e80a8eb03736cfa6d7adabb
https://doi.org/10.1101/2023.05.22.540829
https://doi.org/10.1101/2023.05.22.540829
Publikováno v:
Science Immunology. 8
Delivery of mRNAs encoding influenza HA antigens covering all known subtypes and lineages elicits cross-reactive and protective immunity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f519659fd01309f5b5be905b246412c4
https://doi.org/10.1126/sciimmunol.adg4686
https://doi.org/10.1126/sciimmunol.adg4686
Autor:
Nian E. Zhou, Su Tang, Xuelin Bian, Maloy K. Parai, Inna V. Krieger, Armando Flores, Pradeep K. Jaiswal, Radha Bam, Jeremy L. Wood, Zhe Shi, Laura J. Stevens, Trevor Scobey, Meghan V. Diefenbacher, Fernando R. Moreira, Thomas J. Baric, Arjun Acharya, Joonyoung Shin, Manish M. Rathi, Karen C. Wolff, Laura Riva, Malina A. Bakowski, Case W. McNamara, Nicholas J. Catanzaro, Rachel L. Graham, David C. Schultz, Sara Cherry, Yoshihiro Kawaoka, Peter J. Halfmann, Ralph S. Baric, Mark R. Denison, Timothy P. Sheahan, James C. Sacchettini
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114929- (2024)
Summary: Safe, effective, and low-cost oral antiviral therapies are needed to treat those at high risk for developing severe COVID-19. To that end, we performed a high-throughput screen to identify non-peptidic, non-covalent inhibitors of the SARS-Co
Externí odkaz:
https://doaj.org/article/fee5e4e3bedd475abadbb75db127898b
Autor:
Drake T. Philip, Nigel M. Goins, Nicholas J. Catanzaro, Ichiro Misumi, Jason K. Whitmire, Hannah M. Atkins, Helen M. Lazear
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTType III interferons (IFN-λ) are antiviral and immunomodulatory cytokines that have been best characterized in respiratory and gastrointestinal infections, but the effects of IFN-λ against skin infections have not been extensively investiga
Externí odkaz:
https://doaj.org/article/8b8c514b3e5746b5ada001da89837ded
Autor:
A. Brenda Kapingidza, Daniel J. Marston, Caitlin Harris, Daniel Wrapp, Kaitlyn Winters, Dieter Mielke, Lu Xiaozhi, Qi Yin, Andrew Foulger, Rob Parks, Maggie Barr, Amanda Newman, Alexandra Schäfer, Amanda Eaton, Justine Mae Flores, Austin Harner, Nicholas J. Catanzaro, Michael L. Mallory, Melissa D. Mattocks, Christopher Beverly, Brianna Rhodes, Katayoun Mansouri, Elizabeth Van Itallie, Pranay Vure, Brooke Dunn, Taylor Keyes, Sherry Stanfield-Oakley, Christopher W. Woods, Elizabeth A. Petzold, Emmanuel B. Walter, Kevin Wiehe, Robert J. Edwards, David C. Montefiori, Guido Ferrari, Ralph Baric, Derek W. Cain, Kevin O. Saunders, Barton F. Haynes, Mihai L. Azoitei
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Immune responses to SARS-CoV-2 primarily target the receptor binding domain of the spike protein, which continually mutates to escape acquired immunity. Other regions in the spike S2 subunit, such as the stem helix and the segment encompassi
Externí odkaz:
https://doaj.org/article/f7c3c671d32d475aacf1c3a48887812f
Autor:
Meghan V. Diefenbacher, Thomas J. Baric, David R. Martinez, Ralph S. Baric, Nicholas J. Catanzaro, Timothy P. Sheahan
Publikováno v:
Virus Research, Vol 339, Iss , Pp 199286- (2024)
The genetic diversity of the coronavirus (CoV) family poses a significant challenge for drug discovery and development. Traditional antiviral drugs often target specific viral proteins from specific viruses which limits their use, especially against
Externí odkaz:
https://doaj.org/article/f4cb635a13784784a2d1ae931b9ec45c