Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Nicholas J, Tardi"'
Autor:
Shivangi Agarwal, Kwi Hye Koh, Nicholas J. Tardi, Chuang Chen, Ranadheer Reddy Dande, Joao Pedro WerneckdeCastro, Yashwanth Reddy Sudhini, Cristina Luongo, Domenico Salvatore, Beata Samelko, Mehmet M. Altintas, Steve Mangos, Antonio Bianco, Jochen Reiser
Publikováno v:
EBioMedicine, Vol 72, Iss , Pp 103617- (2021)
ABSTRACT: Background: Nephrotic syndrome (NS) is associated with kidney podocyte injury and may occur as part of thyroid autoimmunity such as Graves’ disease. Therefore, the present study was designed to ascertain if and how podocytes respond to an
Externí odkaz:
https://doaj.org/article/ac26f616b0024f88b24df376bf577abf
Autor:
Steve Mangos, Domenico Salvatore, Jochen Reiser, Ranadheer Reddy Dande, Kwi Hye Koh, Antonio C. Bianco, Chuang Chen, Joao Pedro WerneckdeCastro, Yashwanth Reddy Sudhini, Cristina Luongo, Nicholas J. Tardi, Beata Samelko, Shivangi Agarwal, Mehmet M. Altintas
Publikováno v:
EBioMedicine
EBioMedicine, Vol 72, Iss, Pp 103617-(2021)
EBioMedicine, Vol 72, Iss, Pp 103617-(2021)
Background: Nephrotic syndrome (NS) is associated with kidney podocyte injury and may occur as part of thyroid autoimmunity such as Graves’ disease. Therefore, the present study was designed to ascertain if and how podocytes respond to and regulate
Autor:
Zhongji Liao, Ke Zhu, Vasil Peev, Salim S. Hayek, Michael L. Merchant, Shuangxin Liu, Beata Samelko, Nicholas J. Tardi, Jochen Reiser, Stefan Hägele, Jon B. Klein, Brian D. Adair, Jianchao Ma, Sanford J. Shattil, M. Amin Arnaout, Jian Cai, Salvatore DiBartolo, Sanja Sever, Ranadheer R. Dande, Kwi Hye Koh, David Cimbaluk, Jing Li, Melissa Tracy, Changli Wei
Publikováno v:
J Clin Invest
Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived circulating signaling molecule that has been implicated in chronic kidney disease, such as focal segmental glomerulosclerosis (FSGS). Typically, native uPAR (isoform 1) tra
Autor:
Vasil Peev, Eunsil Hahm, Hyun Lee, Nicholas J. Tardi, Ranadheer R. Dande, Mehmet M. Altintas, Cao Yanxia, Beata Samelko, Kamalika Mukherjee, Steve Mangos, Jochen Reiser, Vincent P. Schmitz, Kwi Hye Koh, Ha Won Lee, David Cimbaluk
Publikováno v:
Journal of Clinical Investigation. 129:1713-1726
Soluble urokinase receptor (suPAR) is a circulatory molecule that activates αvβ3 integrin on podocytes, causes foot process effacement, and contributes to proteinuric kidney disease. While active integrin can be targeted by antibodies and small mol
Autor:
Changli Wei, Guohui Ren, Fumihiko Matsuda, Mehmet M. Altintas, Jochen Reiser, Kwi Hye Koh, Hidde L. Ploegh, Nicholas J. Tardi, Phillip Ruiz
Publikováno v:
American Journal of Physiology-Renal Physiology. 314:F471-F482
Podocytes are terminally differentiated cells of the kidney filtration barrier with a limited proliferative capacity and are the primary glomerular target for various sources of cellular stress. Accordingly, it is particularly important for podocytes
Autor:
Changli Wei, Mehmet M. Altintas, Hatem A. Elshabrawy, Kevin L. Quick, Ha Won Lee, Steve Mangos, Sanja Sever, Jochen Reiser, Nicholas J. Tardi, Mohd Hafeez Faridi, Vineet Gupta, Samia Q. Khan
Publikováno v:
Journal of the American Society of Nephrology. 26:2741-2752
Podocyte injury and loss mark an early step in the pathogenesis of various glomerular diseases, making these cells excellent targets for therapeutics. However, cell–based high–throughput screening assays for the rational development of podocyte-d
Autor:
Nicholas J. Tardi, Jochen Reiser
Publikováno v:
Journal of the American Society of Nephrology. 28:1329-1331
Transient receptor potential channel C6 (TRPC6) gain-of-function mutations and increased TRPC6 expression in podocytes induce glomerular injury and proteinuria. Sildenafil reduces TRPC6 expression and activity in nonrenal cell types, although the mec
Publikováno v:
Developmental Dynamics. 244:808-825
Background Hostile takeover (Hto) is a Drosophila protein trapping system that allows the investigator to both induce a gene and tag its product. The Hto transposon carries a GAL4-regulated promoter expressing an exon encoding a FLAG-mCherry tag. Upo
Autor:
Jochen Reiser, Samy Hakroush, Changli Wei, Faikah Gueler, Nicholas J. Tardi, Hermann Haller, Chuang Chen, Lynne Staggs, Joon Keun Park, Sergej Erschow, Valentina A. Shchedrina, Nils Hanke, Vincent A. Pham, Martin K. Selig, Mario Schiffer, Marina V. Kasaikina, Beina Teng, Irini Tossidou, Aleksandr Vasilyev, Patricia Schroder, Changkyu Gu, Sanja Sever, Song Rong, Denise Hilfiker-Kleiner, Sandra Merscher
Publikováno v:
Nature Medicine. 21:601-609
Dysregulation of the actin cytoskeleton in podocytes represents a common pathway in the pathogenesis of proteinuria across a spectrum of chronic kidney diseases (CKD). The GTPase dynamin has been implicated in the maintenance of cellular architecture
Autor:
Hyun Lee, Lesley A. Inker, Ranadheer R. Dande, Nikolina Stojanović, Garrett Garborcauskas, Beata Samelko, Jochen Reiser, Morgan E. Grams, Jing Li, Changli Wei, Vineet Gupta, Arshed A. Quyyumi, Martin Zeier, Jeffrey B. Kopp, Yi-An Ko, Vasil Peev, Mehmet M. Altintas, Andrew S. Levey, Salim S. Hayek, Sanja Sever, Kwi Hye Koh, Eunsil Hahm, Adrienne Tin, Cheryl A. Winkler, Ha Won Lee, Melissa Tracy, Nicholas J. Tardi, Michael S. Lipkowitz, Karl Skorecki, Josef Coresh, Barry I. Freedman
Soluble urokinase plasminogen activator receptor (suPAR) independently predicts chronic kidney disease (CKD) incidence and progression. Apolipoprotein L1 (APOL1) gene variants G1 and G2, but not the reference allele (G0), are associated with an incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8128e9677970ef545043ccbfebe4da58
https://www.bib.irb.hr/887558
https://www.bib.irb.hr/887558