Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nicholas J, Raddatz"'
Autor:
Gregory Simandl, Gregory J. Simandl, Evan Hess, Linghai Kong, Nicholas J. Raddatz, Matthew M. Hurley, Brian Maunze, SuJean Choi, Aaron M. Geurts, David A. Baker
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 145-145 (2023)
OBJECTIVES/GOALS: We aim to discover safer and more effective therapeutics for CNS disorders. Current therapeutic development is hindered by dosing out drugs for safe consumption. By identifying proteins with narrow functional roles in the brain (i.e
Externí odkaz:
https://doaj.org/article/e95a333379c64267a47095434505eef3
Autor:
Gregory Simand, Gregory J. Simand, Evan Hess, Linghai Kong, Nicholas J. Raddatz, Matthew M Hurley, Brian Maunze, SuJean Choi, Aron M. Geurts, David A. Baker
Publikováno v:
Journal of Clinical and Translational Science, Vol 6, Pp 76-76 (2022)
OBJECTIVES/GOALS: We aim to determine whether non-neuronal, non-synaptic glutamate signaling mechanisms can be targeted to produce highly specific, narrow changes in brain function that would benefit CNS disorders. To do this, we investigated cogniti
Externí odkaz:
https://doaj.org/article/f0d5bc85c7a9421885ab6fab76126b3b
Autor:
Guanguan Li, Michael R. Stephen, Revathi Kodali, Nicolas M. Zahn, Michael M. Poe, V. V. N. Phani Babu Tiruveedhula, Alec T. Huber, Melissa K. Schussman, Krista Qualmann, Cristina M. Panhans, Nicholas J. Raddatz, David A. Baker, Thomas D. Prevot, Mounira Banasr, Etienne Sibille, Leggy A. Arnold, James M. Cook
Publikováno v:
ARKIVOC, Vol 2018, Iss 4, Pp 158-182 (2018)
Externí odkaz:
https://doaj.org/article/f6c4d0576c1d4e9fab7e1fad18c61994
Autor:
Kayla E Rohr, Harshida Pancholi, Shabi Haider, Christopher Karow, David Modert, Nicholas J Raddatz, Jennifer Evans
Publikováno v:
eLife, Vol 8 (2019)
Annual changes in the environment threaten survival, and numerous biological processes in mammals adjust to this challenge via seasonal encoding by the suprachiasmatic nucleus (SCN). To tune behavior according to day length, SCN neurons display unifi
Externí odkaz:
https://doaj.org/article/b9fe49fd327348a5bf82302351bb7b30
Autor:
Guanguan, Li, Michael R, Stephen, Revathi, Kodali, Nicolas M, Zahn, Michael M, Poe, V V N Phani Babu, Tiruveedhula, Alec T, Huber, Melissa K, Schussman, Krista, Qualmann, Cristina M, Panhans, Nicholas J, Raddatz, David A, Baker, Thomas D, Prevot, Mounira, Banasr, Etienne, Sibille, Leggy A, Arnold, James M, Cook
Publikováno v:
ARKIVOC
A series of novel imidazobenzodiazepine analogs of the lead chiral ligand SH-053–2’F-S-CH(3) (2), an α2/α3/α5 (Bz)GABA (A)ergic receptor subtype selective ligand, which reversed PCP-induced prepulse inhibition (PPI) of acoustic startle, were s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e577352db50f3e0853d47fa9b1a5490
https://pubmed.ncbi.nlm.nih.gov/32774192
https://pubmed.ncbi.nlm.nih.gov/32774192
Autor:
Thomas D. Prevot, Leggy A. Arnold, Nicolas M Zahn, Melissa Schussman, Cristina M Panhans, Revathi Kodali, Michael M. Poe, Mounira Banasr, David A. Baker, Nicholas J Raddatz, V. V. N. Phani Babu Tiruveedhula, Krista J. Qualmann, Guanguan Li, Etienne Sibille, Alec T. Huber, Michael Rajesh Stephen, James M. Cook
Publikováno v:
ARKIVOC, Vol 2018, Iss 4, Pp 158-182 (2018)
A series of novel imidazobenzodiazepine analogs of the lead chiral ligand SH-053-2'F-S-CH3 (2), an α2/α3/α5 (Bz)GABA (A)ergic receptor subtype selective ligand, which reversed PCP-induced prepulse inhibition (PPI) of acoustic startle, were synthes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6751aa6d4ec648f9a26d0728690b1999
https://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/ark.5550190.p010.460
https://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/ark.5550190.p010.460
Autor:
Christopher Karow, Kayla E. Rohr, Harshida Pancholi, Nicholas J Raddatz, David Modert, Jennifer A. Evans, Shabi Haider
Publikováno v:
eLife, Vol 8 (2019)
In winter, as the days become shorter, millions of people find that their mood and energy levels start to drop. They crave carbohydrates, struggle with their weight, and find it harder to get out of bed in the mornings. These individuals are sufferin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44c9d3c0329f1a5e19267f723310018
https://doi.org/10.7554/elife.49578
https://doi.org/10.7554/elife.49578
Publikováno v:
Oxidative Medicine and Cellular Longevity. 2015:1-9
The cystine/glutamate exchanger (systemxc-) mediates the transport of cystine into the cell in exchange for glutamate. By releasing glutamate, systemxc-can potentially cause excitotoxicity. However, through providing cystine to the cell, it regulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a73946188f12e05cf518594ad53cf21
https://doi.org/10.1155/2015/269371
https://doi.org/10.1155/2015/269371
Autor:
David A. Baker, SuJean Choi, Ellen M. Olander, Linghai Kong, Victoria Lutgen, Nicholas J Raddatz, Cristina M Panhans, John R. Mantsch, Krista J. Qualmann, Jon M. Resch
Publikováno v:
Psychopharmacology. 231:4637-4647
Gaps in our understanding of glutamatergic signaling may be key obstacles in accurately modeling complex CNS diseases. System xc - is an example of a poorly understood component of glutamate homeostasis that has the potential to contribute to CNS dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b4cbeed47bb5805045a459352f6fef
https://doi.org/10.1007/s00213-014-3612-4
https://doi.org/10.1007/s00213-014-3612-4