Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Nicholas J, Porter"'
Autor:
Daniel A. Isermann, Joshua K. Raabe, Emma G. Easterly, Joshua C. Schulze, Nicholas J. Porter, Daniel J. Dembkowski, Michael C. Donofrio, Darren R. Kramer, Robert F. Elliott
Publikováno v:
Transactions of the American Fisheries Society. 151:611-629
Publikováno v:
Journal of the American Chemical Society, vol 145, iss 13
Microcrystal electron diffraction (MicroED) is an emerging technique which has shown great potential for describing new chemical and biological molecular structures. [1] Several important structures of small molecules, natural products and peptides h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f65640706ab57d53077dff4bded486
https://escholarship.org/uc/item/3h812065
https://escholarship.org/uc/item/3h812065
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Polyamines bind to nucleic acids and their function is regulated by reversible acetylation. Here, the authors show that histone deacetylase 10 is a polyamine deacetylase and present its crystal structure with a bound polyamine transition state analog
Externí odkaz:
https://doaj.org/article/a275abbed63b43529d75e158a00c61cf
Publikováno v:
Journal of the American Chemical Society, vol 144, iss 20
J Am Chem Soc
J Am Chem Soc
Biocatalytic carbene transfer from diazo compounds is a versatile strategy in asymmetric synthesis. However, the limited pool of stable diazo compounds constrains the variety of accessible products. To overcome this restriction, we have engineered va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ee437a929c71d392993b4e91db539f
https://resolver.caltech.edu/CaltechAUTHORS:20220513-557783000
https://resolver.caltech.edu/CaltechAUTHORS:20220513-557783000
Autor:
Nicholas J. Porter, Jeremy D. Osko, Ina Oehme, Olaf Witt, Johannes Ridinger, David W. Christianson, Peter Sehr, Corey J Herbst-Gervasoni, Aubry K. Miller, Magalie Géraldy, Lars Hellweg, Michael Morgen, Raphael R. Steimbach, Nikolas Gunkel
Publikováno v:
ChemMedChem
We report the synthesis and evaluation of a class of selective multitarget agents for the inhibition of HDAC6, HDAC8, and HDAC10. The concept for this study grew out of a structural analysis of the two selective inhibitors Tubastatin A (HDAC6/10) and
Publikováno v:
Curr Opin Struct Biol
Zinc-dependent histone deacetylases (HDACs) regulate the biological function of histone and non-histone proteins through the hydrolysis of acetyllysine side chains to yield free lysine and acetate. Certain HDAC isozymes exhibit alternative catalytic
Publikováno v:
Chemical Science. 10:6979-6983
The prevalence of L-amino acids in biomolecules has been shown to have teleological importance in biomolecular structure and self-assembly. Recently, biophysical studies have demonstrated that natural L-amino acids can be replaced with non-natural ac
Autor:
David W. Christianson, Christophe Decroos, Matthew A. Deardorff, Ian D. Krantz, Paris R. Watson, Matthew S. Lee, Sarah E. Raible, Nicholas J. Porter, Jeremy D. Osko
Publikováno v:
Journal of Structural Biology
Journal of Structural Biology, Elsevier, 2021, 213 (1), pp.107681. ⟨10.1016/j.jsb.2020.107681⟩
J Struct Biol
Journal of Structural Biology, Elsevier, 2021, 213 (1), pp.107681. ⟨10.1016/j.jsb.2020.107681⟩
J Struct Biol
International audience; Cornelia de Lange Syndrome (CdLS) and associated spectrum disorders are characterized by one or more congenital anomalies including distinctive facial features, upper limb abnormalities, intellectual disability, and other symp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5017a341f39d91a443bf3b56be127d21
https://hal.archives-ouvertes.fr/hal-03106173
https://hal.archives-ouvertes.fr/hal-03106173
Autor:
Jacob M. Hooker, David W. Christianson, Joseph M. Salvino, Johanna Rokka, Nicholas J. Porter, You-Cai Xiao, Jeremy D. Osko, Poli Adi Narayana Reddy, Manfred Jung
Publikováno v:
J Med Chem
Inhibition of histone deacetylase 6 (HDAC6) has emerged as a promising therapeutic strategy for the treatment of cancer, chemotherapy-induced peripheral neuropathy, and neurodegenerative disease. The recent X-ray crystal structure determination of HD
Publikováno v:
Biochemistry. 57:3916-3924
Among the metal-dependent histone deacetylases, the class IIb isozyme HDAC6 is remarkable due to its role in the regulation of microtubule dynamics in the cytosol. Selective inhibition of HDAC6 results in microtubule hyperacetylation, leading to cell