Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Nicholas J, Edmunds"'
Autor:
Harald Sourij, J. Brent Kuzmiski, David A. Griffith, Nicholas J. Edmunds, Ewald Kolesnik, Martin Kapl, Eva Thon-Gutschi, Senka Ljubojevic, Dirk von Lewinski, Igor Knez, Klemens Ablasser, Markus Wallner, Paulina Wakula, Mounir Khafaga, Burkert Pieske
Publikováno v:
Journal of Molecular and Cellular Cardiology. 89:365-375
Glucagon-like peptide-1 receptor (GLP-1R) agonists are a rapidly growing class of drugs developed for treating type-2 diabetes mellitus. Patients with diabetes carry an up to 5-fold greater mortality risk compared to non-diabetic patients, mainly as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77aaf97e0e256dee7ffb7918407a5a7e
https://doi.org/10.1016/j.yjmcc.2015.09.018
https://doi.org/10.1016/j.yjmcc.2015.09.018
Autor:
Paul Brennan, Dominique Westbrook, Colleen P. Gibbons, Robin Ward, Carly L. Nichols, Michael R. Sutton, Mark Holbrook, Julian Blagg, Nicholas J. Edmunds, Alison Bridgeland, Tiffini Brabham, Kelly Conlon, Andrews Mark David, Peter J. Bungay, Gavin A. Whitlock, Alan S. Jessiman, Karin McIntosh, James Root, Martin P. Green, Gordon McMurray, R. Ian Storer, Paul V. Fish, Alan Daniel Brown, Giles Hanton, Kerry af Forselles
New pyrimido[4,5-d]azepines 7 are disclosed as potent 5-HT2C receptor agonists. A preferred example, 7b had minimal activation at either the 5-HT2A or 5-HT2B receptors combined with robust efficacy in a preclinical canine model of stress urinary inco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05dc5f0ff0edfc935edd8d293ee1e0da
https://doi.org/10.1016/j.bmcl.2010.11.120
https://doi.org/10.1016/j.bmcl.2010.11.120
Publikováno v:
BJU International. 102:1029-1033
OBJECTIVE To assess the potentiation of erectile responses induced by electrical stimulation (ES) of the dorsal penile nerve (DPN) in the urethane-anaesthetized rat by the selective melanocortin receptor 4 agonist MB243. MATERIALS AND METHODS Intraca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de0729439c0ffb5ea56f90462734cd3
https://doi.org/10.1111/j.1464-410x.2008.07751.x
https://doi.org/10.1111/j.1464-410x.2008.07751.x
Autor:
Markus, Wallner, Ewald, Kolesnik, Klemens, Ablasser, Mounir, Khafaga, Paulina, Wakula, Senka, Ljubojevic, Eva Maria, Thon-Gutschi, Harald, Sourij, Martin, Kapl, Nicholas J, Edmunds, J Brent, Kuzmiski, David A, Griffith, Igor, Knez, Burkert, Pieske, Dirk, von Lewinski
Publikováno v:
Journal of molecular and cellular cardiology. 89
Glucagon-like peptide-1 receptor (GLP-1R) agonists are a rapidly growing class of drugs developed for treating type-2 diabetes mellitus. Patients with diabetes carry an up to 5-fold greater mortality risk compared to non-diabetic patients, mainly as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b27e0e19122cd38cf96dc6e1c200b12b
https://pubmed.ncbi.nlm.nih.gov/26432951
https://pubmed.ncbi.nlm.nih.gov/26432951
Publikováno v:
The Journal of Physiology. 546:521-527
Hypoxia-evoked vasodilatation is a fundamental regulatory mechanism that is often attributed to adenosine. The identity of the O(2) sensor is unknown. Nitric oxide (NO) inhibits endothelial mitochondrial respiration and ATP generation by competing wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f7393cda33cbecb35e55391775d0eb5
https://doi.org/10.1113/jphysiol.2002.023663
https://doi.org/10.1113/jphysiol.2002.023663