Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nicholas J, Bray"'
Autor:
Claire E. Tume, Sophie L. Chick, Peter A. Holmans, Elliott Rees, Michael C. O’Donovan, Darren Cameron, Nicholas J. Bray
Publikováno v:
Biological Psychiatry Global Open Science, Vol 4, Iss 5, Pp 100345- (2024)
Background: The prefrontal cortex (PFC) has been strongly implicated in the pathophysiology of schizophrenia. Here, we combined high-resolution single-nuclei RNA sequencing data from the human PFC with large-scale genomic data for schizophrenia to id
Externí odkaz:
https://doaj.org/article/98a6613cea174bff997f3b04330cabb4
Autor:
Leonard C. Steg, Gemma L. Shireby, Jennifer Imm, Jonathan P. Davies, Alice Franklin, Robert Flynn, Seema C. Namboori, Akshay Bhinge, Aaron R. Jeffries, Joe Burrage, Grant W. A. Neilson, Emma M. Walker, Leo W. Perfect, Jack Price, Grainne McAlonan, Deepak P. Srivastava, Nicholas J. Bray, Emma L. Cope, Kimberley M. Jones, Nicholas D. Allen, Ehsan Pishva, Emma L. Dempster, Katie Lunnon, Jonathan Mill, Eilis Hannon
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-11 (2021)
Abstract Induced pluripotent stem cells (iPSCs) and their differentiated neurons (iPSC-neurons) are a widely used cellular model in the research of the central nervous system. However, it is unknown how well they capture age-associated processes, par
Externí odkaz:
https://doaj.org/article/18efbbb134be4d4aa4a20747dc35b350
Autor:
Szi Kay Leung, Aaron R. Jeffries, Isabel Castanho, Ben T. Jordan, Karen Moore, Jonathan P. Davies, Emma L. Dempster, Nicholas J. Bray, Paul O’Neill, Elizabeth Tseng, Zeshan Ahmed, David A. Collier, Erin D. Jeffery, Shyam Prabhakar, Leonard Schalkwyk, Connor Jops, Michael J. Gandal, Gloria M. Sheynkman, Eilis Hannon, Jonathan Mill
Publikováno v:
Cell Reports, Vol 37, Iss 7, Pp 110022- (2021)
Summary: Alternative splicing is a post-transcriptional regulatory mechanism producing distinct mRNA molecules from a single pre-mRNA with a prominent role in the development and function of the central nervous system. We used long-read isoform seque
Externí odkaz:
https://doaj.org/article/1417caefb134428cac84fed4a4f86a78
Autor:
Heath E. O’Brien, Eilis Hannon, Matthew J. Hill, Carolina C. Toste, Matthew J. Robertson, Joanne E. Morgan, Gemma McLaughlin, Cathryn M. Lewis, Leonard C. Schalkwyk, Lynsey S. Hall, Antonio F. Pardiñas, Michael J. Owen, Michael C. O’Donovan, Jonathan Mill, Nicholas J. Bray
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-13 (2018)
Abstract Background Genetic influences on gene expression in the human fetal brain plausibly impact upon a variety of postnatal brain-related traits, including susceptibility to neuropsychiatric disorders. However, to date, there have been no studies
Externí odkaz:
https://doaj.org/article/451231d2d0294c8c87bcc47a19e30cea
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-14 (2017)
Abstract Background Epigenetic processes play a key role in orchestrating transcriptional regulation during the development of the human central nervous system. We previously described dynamic changes in DNA methylation (5mC) occurring during human f
Externí odkaz:
https://doaj.org/article/c51974de697848c89ab7ed9b661fb8fc
Autor:
Darren Cameron, Da Mi, Ngoc-Nga Vinh, Caleb Webber, Meng Li, Oscar Marín, Michael C. O’Donovan, Nicholas J. Bray
Background\udWhile a variety of evidence supports a prenatal component to schizophrenia, there are few data regarding the cell populations involved. We sought to identify cells of the human prenatal brain mediating genetic risk for schizophrenia by i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df1e19d964a05e9ae6a6469f1b9105e8
https://orca.cardiff.ac.uk/id/eprint/151244/1/PIIS0006322322014044.pdf
https://orca.cardiff.ac.uk/id/eprint/151244/1/PIIS0006322322014044.pdf
Autor:
Carolina C, Toste, Rodrigo R R, Duarte, Aaron R, Jeffries, Sashika, Selvackadunco, Claire, Troakes, Michael C, O'Donovan, Matthew J, Hill, Nicholas J, Bray
Publikováno v:
Molecular neuropsychiatry. 5(4)
A genome-wide significant association has been reported between non-coding variants at the dopamine D2 receptor (DRD2) gene locus and schizophrenia. However, effects of identified schizophrenia risk alleles on DRD2 function are yet to be demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ba9972aba1f8d0388ba54b15a9ac4d10
https://pubmed.ncbi.nlm.nih.gov/31768374
https://pubmed.ncbi.nlm.nih.gov/31768374
Autor:
Matthew J, Hill, Richard, Killick, Katherinne, Navarrete, Aleksandra, Maruszak, Gemma M, McLaughlin, Brenda P, Williams, Nicholas J, Bray
Publikováno v:
Journal of psychiatryneuroscience : JPN. 42(3)
Common variants in theTo explore molecular and cellular mechanisms by which TCF4 perturbation could interfere with human cortical development, we experimentally reduced the endogenous expression of TCF4 in a neural progenitor cell line derived from t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a2348788abc69ba8f5149c8da554d364
https://pubmed.ncbi.nlm.nih.gov/27689884
https://pubmed.ncbi.nlm.nih.gov/27689884
Autor:
Rodrigo R R, Duarte, Claire, Troakes, Matthew, Nolan, Deepak P, Srivastava, Robin M, Murray, Nicholas J, Bray
Publikováno v:
American Journal of Medical Genetics
Chromosome 10q24.32‐q24.33 is one of the most robustly supported risk loci to emerge from genome‐wide association studies (GWAS) of schizophrenia. However, extensive linkage disequilibrium makes it difficult to distinguish the actual susceptibili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2ad6895fa1c28ab2d439b4352ea6cbe6
https://pubmed.ncbi.nlm.nih.gov/27004590
https://pubmed.ncbi.nlm.nih.gov/27004590