Výsledky vyhledávání - "Nicholas J, Bessman"

Akademický článek

Complex Relationship between Ligand Binding and Dimerization in the Epidermal Growth Factor Receptor

Autor: Nicholas J. Bessman, Atrish Bagchi, Kathryn M. Ferguson, Mark A. Lemmon

Publikováno v: Cell Reports, Vol 9, Iss 4, Pp 1306-1317 (2014)

The epidermal growth factor receptor (EGFR) plays pivotal roles in development and is mutated or overexpressed in several cancers. Despite recent advances, the complex allosteric regulation of EGFR remains incompletely understood. Through efforts to

Externí odkaz: https://doaj.org/article/2a10d9751d404d5581278cd2a95c28ed

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Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection

Autor: Wen Zhang, Mengze Lyu, Nicholas J. Bessman, Zili Xie, Mohammad Arifuzzaman, Hiroshi Yano, Christopher N. Parkhurst, Coco Chu, Lei Zhou, Gregory G. Putzel, Ting-Ting Li, Wen-Bing Jin, Jordan Zhou, Hongzhen Hu, Amy M. Tsou, Chun-Jun Guo, David Artis

Publikováno v: Cell. 185:4170-4189.e20

Nociceptive pain is a hallmark of many chronic inflammatory conditions including inflammatory bowel diseases (IBDs); however, whether pain-sensing neurons influence intestinal inflammation remains poorly defined. Employing chemogenetic silencing, ade

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32de5ff473f2d012b08634331e49545
https://doi.org/10.1016/j.cell.2022.09.008

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The microbiota regulate neuronal function and fear extinction learning

Publikováno v: Nature

Multicellular organisms have co-evolved with complex consortia of viruses, bacteria, fungi and parasites, collectively referred to as the microbiota1. In mammals, changes in the composition of the microbiota can influence many physiologic processes (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be788f217e2239a84f9c6d4177f52ef3
https://doi.org/10.1038/s41586-019-1644-y

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Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing

Publikováno v: Bessman, N J, Mathieu, J R R, Renassia, C, Zhou, L, Fung, T C, Fernandez, K C, Austin, C, Moeller, J B, Zumerle, S, Louis, S, Vaulont, S, Ajami, N J, Sokol, H, Putzel, G G, Arvedson, T, Sockolow, R E, Lakhal-Littleton, S, Cloonan, S M, Arora, M, Peyssonnaux, C & Sonnenberg, G F 2020, ' Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing ', Science, vol. 368, no. 6487, pp. 186-189 . https://doi.org/10.1126/science.aau6481
Science

Ironing out the details of mucosal healing Anemia is a frequent complication of disorders such as inflammatory bowel disease, occurring in part as a result of increased bleeding into the intestine. Bessman et al. show that the peptide hormone hepcidi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5798ad0380e27f54d4544677e84dcb14
https://portal.findresearcher.sdu.dk/da/publications/adca1f33-4e77-409a-9abc-9aa75251b9c6

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Interleukin-33 Induces the Enzyme Tryptophan Hydroxylase 1 to Promote Inflammatory Group 2 Innate Lymphoid Cell-Mediated Immunity

Autor: Zhengxiang He, Wen Zhang, Saya Moriyama, Sergio A. Lira, Jesper B. Moeller, Christoph S.N. Klose, David Artis, Lucille C. Rankin, Lili Chen, Anne-Laure Flamar, Nicholas J. Bessman, Gerard Karsenty, Gregory G. Putzel, Vladislava Stokic-Trtica, Tanel Mahlakõiv, Hans Reimer Rodewald

Publikováno v: Immunity
Flamar, A L, Klose, C S N, Moeller, J B, Mahlakõiv, T, Bessman, N J, Zhang, W, Moriyama, S, Stokic-Trtica, V, Rankin, L C, Putzel, G G, Rodewald, H R, He, Z, Chen, L, Lira, S A, Karsenty, G & Artis, D 2020, ' Interleukin-33 Induces the Enzyme Tryptophan Hydroxylase 1 to Promote Inflammatory Group 2 Innate Lymphoid Cell-Mediated Immunity ', Immunity, vol. 52, no. 4, pp. 606-619.e6 . https://doi.org/10.1016/j.immuni.2020.02.009

Group 2 innate lymphoid cells (ILC2s) regulate immunity, inflammation, and tissue homeostasis. Two distinct subsets of ILC2s have been described: steady-state natural ILC2s and inflammatory ILC2s, which are elicited following helminth infection. Howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc32cd6e1b81971a87c42a7ae7617c45

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Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1

Autor: Gregory G. Putzel, David Artis, Jesper B. Moeller, Irina Leonardi, Iliyan D. Iliev, Christine Elise Schøler Jepsen, Ernst-Martin Füchtbauer, Nicholas J. Bessman, Karsten Skjødt, Anders Schlosser, Mark Hammond, Grith Lykke Sørensen, Theresa Thomsen, Uffe Holmskov, Anne-Laure Flamar, Donna L. Farber

Publikováno v: Moeller, J B, Leonardi, I, Schlosser, A, Flamar, A-L, Bessman, N J, Putzel, G G, Thomsen, T, Hammond, M, Jepsen, C S, Skjødt, K, Füchtbauer, E-M, Farber, D L, Sorensen, G L, Iliev, I D, Holmskov, U & Artis, D 2019, ' Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1 ', The Journal of Experimental Medicine, vol. 216, no. 12, pp. 2689-2700 . https://doi.org/10.1084/jem.20182244
The Journal of Experimental Medicine
Moeller, J B, Leonardi, I, Schlosser, A, Flamar, A L, Bessman, N J, Putzel, G G, Thomsen, T, Hammond, M, Jepsen, C S, Skjødt, K, Füchtbauer, E M, Farber, D L, Sorensen, G L, Iliev, I D, Holmskov, U & Artis, D 2019, ' Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1 ', The Journal of Experimental Medicine, vol. 216, no. 12, pp. 2689-2700 . https://doi.org/10.1084/jem.20182244

In the present study, Moeller et al. identify a previously unrecognized pathway through which intestinal epithelial cells expressing the novel chitin-binding receptor FIBCD1 can recognize and control intestinal fungal colonization, limit fungal dysbi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85339131815355f437b5bc445395583b
https://findresearcher.sdu.dk:8443/ws/files/169995901/Open_Access_version

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Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2

Autor: Jeremy Goc, Gregory G. Putzel, Hiroki Kabata, Judith R. Kelsen, Manish A. Shah, Endi K. Santosa, Gérard Eberl, Gregory F. Sonnenberg, Coco Chu, Kendall A. Smith, Fei Teng, Lei Zhou, Robbyn Sockolow, Robert N. Baldassano, Nicholas J. Bessman, Eric Vivier

Publikováno v: Nature
Nature, 2019, 568 (7752), pp.405-409. ⟨10.1038/s41586-019-1082-x⟩
Nature, Nature Publishing Group, 2019, 568 (7752), pp.405-409. ⟨10.1038/s41586-019-1082-x⟩

International audience; Interleukin (IL)-2 is a pleiotropic cytokine that is necessary to prevent chronic inflammation in the gastrointestinal tract 1-4. The protective effects of IL-2 involve the generation, maintenance and function of regulatory T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b74b95cc1414507458227043fc6212
https://hal-pasteur.archives-ouvertes.fr/pasteur-03258606

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Emerging roles for antigen presentation in establishing host-microbiome symbiosis

Autor: Nicholas J. Bessman, Gregory F. Sonnenberg

Publikováno v: Immunological Reviews. 272:139-150

Trillions of beneficial bacteria inhabit the intestinal tract of healthy mammals from birth. Accordingly, mammalian hosts have evolved a series of complementary and redundant pathways to limit pathologic immune responses against these bacteria, while

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e3ce794e485cd0d211fc17f61395b9
https://doi.org/10.1111/imr.12425

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