Mismatch repair deficiency and microsatellite instability in urothelial carcinoma: a systematic review and meta-analysis

Autor: Ninet Sinaii, Guru Sonpavde, Amin H Nassar, Min Yuen Teo, Andrea B Apolo, Jonathan E Rosenberg, Giovanni Maria Iannantuono, Elias B A Chandran, Saad O Atiq, Dilara Akbulut, Nicholas I Simon, Abdul Rouf Banday, Salah Boudjadi, Sandeep Gurram, Gisela Butera, Jonathan A Coleman

Publikováno v: BMJ Oncology, Vol 3, Iss 1 (2024)

Background Mismatch repair deficiency (dMMR) and microsatellite instability-high (MSI-H) occur in a subset of cancers and have been shown to confer sensitivity to immune checkpoint inhibition (ICI); however, there is a lack of prospective data in uro

Externí odkaz: https://doaj.org/article/d3920c29bad4423893885de5201f3040

Figures S1 - S9 from BMX-Mediated Regulation of Multiple Tyrosine Kinases Contributes to Castration Resistance in Prostate Cancer

Autor: Steven P. Balk, Nathanael S. Gray, Nicholas I. Simon, Xin Yuan, Fen Ma, Huihui Ye, Adam G. Sowalsky, Changmeng Cai, Sen Chen

Figure S1. Inducible BMX knockdown suppresses CWR22RV1 tumor growth in vitro and in vivo; Figure S2. Schematic picture of BMX signaling pathway; Figure S3. The effect of BMX SiRNA smart pool on CWR22RV1 cell response to serum stimulation; Figure S4.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42262c6c7014c4213910d46e1648f1be
https://doi.org/10.1158/0008-5472.22420464.v1

Best Approaches and Updates for Prostate Cancer Biochemical Recurrence

Autor: Nicholas I. Simon, Chris Parker, Thomas A. Hope, Channing J. Paller

Publikováno v: Am Soc Clin Oncol Educ Book
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting, vol 42, iss 42

Biochemical recurrence develops in almost one-third of men with prostate cancer after treatment with local therapy. There are numerous options for management, including surveillance, salvage radiation, androgen deprivation therapy (ADT), and clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::840771d7508c6a531558d8d41ed94d55
https://pubmed.ncbi.nlm.nih.gov/35503984

Understanding drivers of treatment preferences in locally advanced or metastatic urothelial carcinoma: A qualitative interview study with patients, caregivers, and physicians

Autor: Andrea B. Apolo, Nicholas I. Simon, Mallory Farrar, Simrun Grewal, Zsolt Hepp, Lisa Mucha, Christine Michaels-Igbokwe, Sebastian Heidenreich, Katelyn Cutts, John L. Gore

Publikováno v: Journal of Clinical Oncology. 41:492-492

492 Background: The development and selection of treatments for locally advanced or metastatic urothelial carcinoma (la/mUC) have historically focused on clinical outcomes while stakeholder preferences are often considered less frequently. To facilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ab1c27288dc22e7170e8afe92eebcf3
https://doi.org/10.1200/jco.2023.41.6_suppl.492

The association of FDG PET/CT and NaF PET/CT with survival outcomes in patients (pts) with metastatic genitourinary malignancies (mGU) treated with cabozantinib + nivolumab +/- ipilimumab (CaboNivo +/- Ipi)

Autor: Nicholas I. Simon, Katherine Lei, Nicholas Peter Verdini, Jeffrey Lin, Andy Vega, Scot Anthony Niglio, Amir Mortazavi, Sumanta K. Pal, Jeffrey Kempf, Murray Becker, Michael V. Knopp, Chadwick Wright, Alex Jung, Peter L. Choyke, Seth M. Steinberg, Esther Mena, Liza Lindenberg, Andrea B. Apolo

Publikováno v: Journal of Clinical Oncology. 40:452-452

452 Background: This study determined the association of functional imaging parameters obtained on FDG PET/CT and NaF PET/CT with OS for pts with mGU malignancies treated on a phase I study with CaboNivo +/- Ipi. Methods: Pts on this phase I study un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::520cc7fb0b5f297cf30028cb998fb749
https://doi.org/10.1200/jco.2022.40.6_suppl.452