Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nicholas I. McCarthy"'
Autor:
Adrian M. Shields, Sian E. Faustini, Siobhan Young, Sarah Terjesen, Nicholas I. McCarthy, Rachel L. Anderson, Mark T. Drayson, Alex G. Richter
Publikováno v:
eJHaem, Vol 4, Iss 2, Pp 339-349 (2023)
Abstract Secondary immunodeficiency (SID), manifesting as increased susceptibility to infection, is an emergent clinical problem in haematoncology. Management of SID includes vaccination, prophylactic antibiotics (pAbx) and immunoglobulin replacement
Externí odkaz:
https://doaj.org/article/ce8f1af0fdd245048ca093557910b485
Publikováno v:
Cell Reports, Vol 14, Iss 5, Pp 1041-1048 (2016)
Summary: Current models of Foxp3+ regulatory T cell (Treg) development involve CCR7-mediated migration of thymocytes into the thymus medulla to enable essential interactions with medullary epithelium. However, increased Foxp3+ thymic Treg numbers in
Externí odkaz:
https://doaj.org/article/a3f7e5b6fef74e41aca77d559c4a1414
Autor:
Aimee Jackson, Sylvie D. Freeman, Ann Hunter, Richard Dillon, Victoria T Potter, Georgia Andrew, Jiri Pavlu, Rahuman Salim, Sandeep Nagra, Ram Malladi, Shamyla Siddique, Eleni Tholouli, Rachel Protheroe, Naeem Khan, Keith Wheatley, Keith G. Wilson, Nicholas I. McCarthy, Charles Craddock, Jenny Byrne, Anne Parker, Maria H. Gilleece, Andrea Hodgkinson, Justin Loke, Andrew Peniket, John Mason, Paresh Vyas, Charles Crawley
Publikováno v:
Journal of Clinical Oncology. 39:768-778
PURPOSE Reduced-intensity conditioning (RIC) regimens have extended the curative potential of allogeneic stem-cell transplantation to older adults with high-risk acute myeloid leukemia (AML) and myelodysplasia (MDS) but are associated with a high ris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1640c093b08c2f33256f082f86fec6
https://doi.org/10.1200/jco.20.02308
https://doi.org/10.1200/jco.20.02308
Autor:
Richard Dillon, Rachel Protheroe, Eleni Tholouli, Andy Peniket, Shamyla Siddique, Nicholas I. McCarthy, Victoria Potter, Georgia M. Andrew, John Mason, Aimee Jackson, Sylvie D. Freeman, Naeem Khan, Justin Loke, Keith Wilson, Andrea Hodgkinson, Pramila Krishnamurthy, Charles Craddock, Maria H. Gilleece, Rahuman Salim, Charles Crawley
Publikováno v:
Blood. 138:415-415
Allogeneic stem-cell transplantation is an important curative strategy in acute myeloid leukaemia (AML) consequent upon the development of a graft-versus-leukaemia (GVL) effect. Disease relapse is the major cause of transplant failure and novel thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fedbbb94546a980ccbc3abd92c1fa3d
https://doi.org/10.1182/blood-2021-149269
https://doi.org/10.1182/blood-2021-149269
Autor:
Susan M. Kaech, Nicholas I. McCarthy, Natalie A. Roberts, Sonia M. Parnell, Reuben Tooze, Graham Anderson, Brian D. Adams, Valerie Horsley
Publikováno v:
The Journal of Immunology Author Choice
Autoimmunity is largely prevented by medullary thymic epithelial cells (TECs) through their expression and presentation of tissue-specific Ags to developing thymocytes, resulting in deletion of self-reactive T cells and supporting regulatory T cell d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634f1d2bca22540351cfc143fadfabcd
https://doi.org/10.4049/jimmunol.1600941
https://doi.org/10.4049/jimmunol.1600941
Autor:
Lena Wyss, Nicholas I. McCarthy, Eric S. Huseby, Graham Anderson, Sonja Schallenberg, Luigi Terracciano, Karsten Kretschmer, Junyoung Lee, Charles D. Surh, Ed Palmer, Carolyn G. King, Brian D. Stadinski
Publikováno v:
Nature immunology
The manner in which regulatory T cells (Treg cells) control lymphocyte homeostasis is not fully understood. We identified two Treg cell populations with differing degrees of self-reactivity and distinct regulatory functions. We found that GITR(hi)PD-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f9dd3f8a750392b24d5b4148e50341
https://doi.org/10.1038/ni.3522
https://doi.org/10.1038/ni.3522
Autor:
Jennifer E, Cowan, Song, Baik, Nicholas I, McCarthy, Sonia M, Parnell, Andrea J, White, William E, Jenkinson, Graham, Anderson
Publikováno v:
European journal of immunology. 48(5)
In the thymus, medullary thymic epithelial cells (mTEC) determine the fate of newly selected CD4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7c9933fcdedd6adf18213270acf153cc
https://pubmed.ncbi.nlm.nih.gov/29285761
https://pubmed.ncbi.nlm.nih.gov/29285761
Autor:
Beth, Lucas, Nicholas I, McCarthy, Song, Baik, Emilie, Cosway, Kieran D, James, Sonia M, Parnell, Andrea J, White, William E, Jenkinson, Graham, Anderson
Publikováno v:
Immunological Reviews
Summary The thymus is a primary lymphoid tissue that supports the generation of αβT cells. In this review, we describe the processes that give rise to the thymus medulla, a site that nurtures self‐tolerant T‐cell generation following positive s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fbae961fa16fe769b17ca07bd2dec6fe
https://pubmed.ncbi.nlm.nih.gov/27088905
https://pubmed.ncbi.nlm.nih.gov/27088905
Autor:
William E. Jenkinson, Beth Lucas, Graham Anderson, Jennifer E. Cowan, Nicholas I. McCarthy, Kieran D. James, Song Baik
The thymus is a primary lymphoid tissue that is unique in its ability to support a full program of T cell development. Thymic microenvironments consist of anatomically distinct cortical and medullary areas that shape the developing T cell repertoire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f22e0241c555a6c3a5686827370936f3
https://doi.org/10.1016/b978-0-12-374279-7.07001-6
https://doi.org/10.1016/b978-0-12-374279-7.07001-6
Publikováno v:
Cell Reports
Summary Current models of Foxp3+ regulatory T cell (Treg) development involve CCR7-mediated migration of thymocytes into the thymus medulla to enable essential interactions with medullary epithelium. However, increased Foxp3+ thymic Treg numbers in C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0df489db12543c2a2e17735452a61938
https://pubmed.ncbi.nlm.nih.gov/26832402
https://pubmed.ncbi.nlm.nih.gov/26832402