Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nicholas Holdreith"'
Autor:
Leilei Zhong, Jiawei Lu, Jiankang Fang, Lutian Yao, Wei Yu, Tao Gui, Michael Duffy, Nicholas Holdreith, Catherine A Bautista, Xiaobin Huang, Shovik Bandyopadhyay, Kai Tan, Chider Chen, Yongwon Choi, Jean X Jiang, Shuying Yang, Wei Tong, Nathanial Dyment, Ling Qin
Publikováno v:
eLife, Vol 12 (2023)
Colony-stimulating factor 1 (Csf1) is an essential growth factor for osteoclast progenitors and an important regulator for bone resorption. It remains elusive which mesenchymal cells synthesize Csf1 to stimulate osteoclastogenesis. We recently identi
Externí odkaz:
https://doaj.org/article/bb1b12b6a7ed4afd8c68a366c9066d9a
Autor:
Leilei Zhong, Lutian Yao, Nicholas Holdreith, Wei Yu, Tao Gui, Zhen Miao, Yehuda Elkaim, Mingyao Li, Yanqing Gong, Maurizio Pacifici, Amit Maity, Theresa M. Busch, Kyu Sang Joeng, Keith Cengel, Patrick Seale, Wei Tong, Ling Qin
Publikováno v:
JCI Insight, Vol 7, Iss 7 (2022)
Radiation causes a collapse of bone marrow cells and elimination of microvasculature. To understand how bone marrow recovers after radiation, we focused on mesenchymal lineage cells that provide a supportive microenvironment for hematopoiesis and ang
Externí odkaz:
https://doaj.org/article/3e4aca805ba8470286d4476776986427
Autor:
Leilei Zhong, Lutian Yao, Robert J Tower, Yulong Wei, Zhen Miao, Jihwan Park, Rojesh Shrestha, Luqiang Wang, Wei Yu, Nicholas Holdreith, Xiaobin Huang, Yejia Zhang, Wei Tong, Yanqing Gong, Jaimo Ahn, Katalin Susztak, Nathanial Dyment, Mingyao Li, Fanxin Long, Chider Chen, Patrick Seale, Ling Qin
Publikováno v:
eLife, Vol 9 (2020)
Bone marrow mesenchymal lineage cells are a heterogeneous cell population involved in bone homeostasis and diseases such as osteoporosis. While it is long postulated that they originate from mesenchymal stem cells, the true identity of progenitors an
Externí odkaz:
https://doaj.org/article/e1bde3bf4480496eb8cd45466e510294
Autor:
Joanna Balcerek, Jing Jiang, Yang Li, Qinqin Jiang, Nicholas Holdreith, Brijendra Singh, Vemika Chandra, Kaosheng Lv, Jian-gang Ren, Krasimira Rozenova, Weihua Li, Roger A. Greenberg, Wei Tong
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Loss of Fancd2 leads to replication stress intolerance and Fanconi Anemia, where haematopoietic stem cell (HSC) function is compromised. Here, the authors show that Lnk/Sh2b3 loss restores HSC proliferation and survival in Fancd2 knockout mice and am
Externí odkaz:
https://doaj.org/article/d467920db1af4931b19c732f10975998
Autor:
Leilei Zhong, Jiawei Lu, Jiankang Fang, Lutian Yao, Wei Yu, Tao Gui, Michael Duffy, Nicholas Holdreith, Catherine A Bautista, Xiaobin Huang, Shovik Bandyopadhyay, Kai Tan, Chider Chen, Yongwon Choi, Jean X Jiang, Shuying Yang, Wei Tong, Nathanial Dyment, Ling Qin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::998cbdbbf61063280a03418c9452d100
https://doi.org/10.7554/elife.82112.sa2
https://doi.org/10.7554/elife.82112.sa2
Autor:
Leilei Zhong, Jiawei Lu, Jiankang Fang, Lutian Yao, Wei Yu, Tao Gui, Nicholas Holdreith, Catherine Bautista, Yongwon Choi, Jean X. Jiang, Shuying Yang, Wei Tong, Nathaniel Dyment, Ling Qin
Colony stimulating factor 1 (Csf1) is an essential growth factor for osteoclast progenitors and thus an important regulator for bone resorption. It remains elusive which mesenchymal cells synthesize Csf1 stimulating osteoclastogenesis. We recently id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aed2ec037312b3c86f0d7a8c5069b721
https://doi.org/10.1101/2022.07.27.501742
https://doi.org/10.1101/2022.07.27.501742
Autor:
Leilei Zhong, Lutian Yao, Nicholas Holdreith, Wei Yu, Tao Gui, Zhen Miao, Yehuda Elkaim, Mingyao Li, Yanqing Gong, Maurizio Pacifici, Amit Maity, Theresa M. Busch, Kyu Sang Joeng, Keith Cengel, Patrick Seale, Wei Tong, Ling Qin
Publikováno v:
JCI insight. 7(7)
Radiation causes a collapse of bone marrow cells and elimination of microvasculature. To understand how bone marrow recovers after radiation, we focused on mesenchymal lineage cells that provide a supportive microenvironment for hematopoiesis and ang
Autor:
Hyunsoo Kim, Wei Yu, Yulong Wei, X. Sherry Liu, Shuying Yang, Yongwon Choi, Lutian Yao, Nathaniel A. Dyment, Ziqing Li, Xi Jiang, Wei Tong, Leilei Zhong, Tao Gui, Nicholas Holdreith, Jaimo Ahn, Ling Qin
Publikováno v:
J Clin Invest
Bone is maintained by coupled activities of bone-forming osteoblasts/osteocytes and bone-resorbing osteoclasts. Alterations in this relationship can lead to pathologic bone loss such as osteoporosis. It is well known that osteogenic cells support ost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc8e8eaef8ab6e3af3627883de70ea24
https://europepmc.org/articles/PMC7810488/
https://europepmc.org/articles/PMC7810488/
Autor:
Nicholas Holdreith, Vemika Chandra, Carlo Salas Salinas, Grace Y Lee, Timothy S. Olson, Peter Nicholas, Wei Tong
Publikováno v:
Blood advances. 6(3)
Hematopoietic stem cell transplantation (HSCT) remains the only curative treatment for a variety of hematological diseases. Allogenic HSCT requires hematopoietic stem cells (HSCs) from matched donors and comes with cytotoxicity and mortality. Recent
Autor:
Peng Gao, Danuta Jarocha, Varun Sudunagunta, Mortimer Poncz, Nicholas Holdreith, Sara Borst, Wei Tong, Paul P. Liu, Sumedha Bagga, Deborah L. French, James Garifallou, Kai Tan, Paul Gadue, Nancy A. Speck, Michael Gonzalez, Hakon Hakonarson, Brian Estevez
Patients with familial platelet disorder with a predisposition to myeloid malignancy (FPDMM) harbor germline monoallelic mutations in a key hematopoietic transcription factor RUNX1. Previous studies of FPDMM have focused on megakaryocyte (Mk) differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a364d1283f6fd1c390e9d86dfc1353a5
https://doi.org/10.1101/2020.08.23.260281
https://doi.org/10.1101/2020.08.23.260281