Hydrogen peroxide stimulates activity and alters behavior in Drosophila melanogaster.

Autor: Dhruv Grover, Daniel Ford, Christopher Brown, Nicholas Hoe, Aysen Erdem, Simon Tavaré, John Tower

Publikováno v: PLoS ONE, Vol 4, Iss 10, p e7580 (2009)

Circadian rhythms in animals are regulated at the level of individual cells and by systemic signaling to coordinate the activities of multiple tissues. The circadian pacemakers have several physiological outputs, including daily locomotor rhythms. Se

Externí odkaz: https://doaj.org/article/d682b4a5793d45cf85e02d6e5b850a00

Supplementary Figures 1-3 from Immune Profiling and Quantitative Analysis Decipher the Clinical Role of Immune-Checkpoint Expression in the Tumor Immune Microenvironment of DLBCL

Autor: Ken H. Young, Gordon J. Freeman, Yong Li, George Z. Rassidakis, L. Jeffrey Medeiros, Lan V. Pham, Jason R. Westin, Jane N. Winter, J. Han van Krieken, Miguel A. Piris, Michael B. Møller, Andrés J.M. Ferreri, Maurilio Ponzoni, Eric D. Hsi, Govind Bhagat, Hua You, Wayne Tam, Karen Dybkær, Jing Wang, Alexandar Tzankov, Hongwei Zhang, Xiaohong Tan, Yi Miao, Carlo Visco, Ganiraju C. Manyam, Raul Torres-Ruiz, Sandra Rodríguez-Perales, Nicholas Hoe, Bing Xu, Raghav Padmanabhan, Qingyan Au, Min Xiao, Ziju Y. Xu-Monette

Supplementary Figures S1 to S3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457727be1620a46e488c64d429f6ad02
https://doi.org/10.1158/2326-6066.22538953

LSD increases sleep duration the night after microdosing

Autor: Nathan Allen, Aron Jeremiah, Robin Murphy, Rachael Sumner, Anna Forsyth, Nicholas Hoeh, David B. Menkes, William Evans, Suresh Muthukumaraswamy, Frederick Sundram, Partha Roop

Publikováno v: Translational Psychiatry, Vol 14, Iss 1, Pp 1-8 (2024)

Abstract Microdosing psychedelic drugs at a level below the threshold to induce hallucinations is an increasingly common lifestyle practice. However, the effects of microdosing on sleep have not been previously reported. Here, we report results from

Externí odkaz: https://doaj.org/article/76f5c7976a2947a4ae5d60b9a3240cd4

Drug screen identifies verteporfin as a regulator of lipid metabolism in macrophage foam cells

Autor: Nicholas Hoeffner, Antoni Paul, Young-Hwa Goo

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)

Abstract Arterial macrophage foam cells are filled with cholesterol ester (CE) stored in cytosolic lipid droplets (LDs). Foam cells are central players in progression of atherosclerosis as regulators of lipid metabolism and inflammation, two major dr

Externí odkaz: https://doaj.org/article/a4ef285b06464639b380b9e11c17b716

Immune Profiling and Quantitative Analysis Decipher the Clinical Role of Immune-Checkpoint Expression in the Tumor Immune Microenvironment of DLBCL

Autor: Hongwei Zhang, Karen Dybkær, Miguel A. Piris, Alexandar Tzankov, Jason R. Westin, Ziju Y. Xu-Monette, Jing Wang, Carlo Visco, Jane N. Winter, Maurilio Ponzoni, L. Jeffrey Medeiros, Yi Miao, Ganiraju C. Manyam, Bing Xu, Yong Li, Min Xiao, Hua You, Nicholas Hoe, Gordon J. Freeman, Raúl Torres-Ruiz, Andrés J.M. Ferreri, Wayne Tam, Ken H. Young, Qingyan Au, Govind Bhagat, George Z. Rassidakis, Xiaohong Tan, Eric D. Hsi, Sandra Rodriguez-Perales, Raghav Padmanabhan, Lan V. Pham, Michael Boe Møller, J. Han van Krieken

Publikováno v: Xu-Monette, Z Y, Xiao, M, Au, Q, Padmanabhan, R, Xu, B, Hoe, N, Rodríguez-Perales, S, Torres-Ruiz, R, Manyam, G C, Visco, C, Miao, Y, Tan, X, Zhang, H, Tzankov, A, Wang, J, Dybkær, K, Tam, W, You, H, Bhagat, G, Hsi, E D, Ponzoni, M, Ferreri, A J M, Møller, M B, Piris, M A, van Krieken, J H, Winter, J N, Westin, J R, Pham, L V, Medeiros, L J, Rassidakis, G Z, Li, Y, Freeman, G J & Young, K H 2019, ' Immune Profiling and Quantitative Analysis Decipher the Clinical Role of Immune-Checkpoint Expression in the Tumor Immune Microenvironment of DLBCL ', Cancer Immunology Research, vol. 7, no. 4, pp. 644-657 . https://doi.org/10.1158/2326-6066.CIR-18-0439
Cancer Immunology Research, 7, 644-657
Cancer Immunology Research, 7, 4, pp. 644-657
Xu-Monette, Z, Xiao, M, Au, Q, Padmanabhan, R, Xu, B, Hoe, N, Rodriguez-Perales, S, Torres-Ruiz, R, Manyam, G, Visco, C, Miao, Y, Tan, X, Zhang, H, Tzankov, A, Wang, J, Dybkaer, K, Tam, W, You, H, Bhagat, G, Hsi, E D, Ponzoni, M, Ferreri, A J M, Møller, M B, Piris, M A, van Krieken, J H, Winter, J N, Westin, J R, Pham, L V, Medeiros, L J, Rassidakis, G Z, Li, Y, Freeman, G J & Young, K H 2019, ' Immune profiling and quantitative analysis decipher the clinical role of immune checkpoint expression in the tumor immune microenvironment of DLBCL ', Cancer Immunology Research, vol. 7, no. 4, pp. 644-657 . https://doi.org/10.1158/2326-6066.CIR-18-0439

PD-1/L1 and CTLA-4 blockade immunotherapies have been approved for 13 types of cancers and are being studied in diffuse large B-cell lymphoma (DLBCL), the most common aggressive B-cell lymphoma. However, whether both PD-1 and CTLA-4 checkpoints are a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd2bda5c650a913672e02e5151bffdab
http://hdl.handle.net/11562/1011409