Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Nicholas Hasle"'
Autor:
Nicholas Hasle, Anthony Cooke, Sanjay Srivatsan, Heather Huang, Jason J Stephany, Zachary Krieger, Dana Jackson, Weiliang Tang, Sriram Pendyala, Raymond J Monnat, Cole Trapnell, Emily M Hatch, Douglas M Fowler
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 6, Pp 1-18 (2020)
Abstract Microscopy is a powerful tool for characterizing complex cellular phenotypes, but linking these phenotypes to genotype or RNA expression at scale remains challenging. Here, we present Visual Cell Sorting, a method that physically separates h
Externí odkaz:
https://doaj.org/article/f34f0d3435be4971918d05251757a448
Autor:
Vanessa E. Gray, Katherine Sitko, Floriane Z. Ngako Kameni, Miriam Williamson, Jason J. Stephany, Nicholas Hasle, Douglas M. Fowler
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 11, Pp 3683-3689 (2019)
Despite the importance of Aβ aggregation in Alzheimer’s disease etiology, our understanding of the sequence determinants of aggregation is sparse and largely derived from in vitro studies. For example, in vitro proline and alanine scanning mutagen
Externí odkaz:
https://doaj.org/article/3a130f00608a47b499fd78d1c5485daa
Autor:
Nicholas Hasle, Cole Trapnell, Weiliang Tang, Sanjay Srivatsan, Jason J. Stephany, Emily M. Hatch, Sriram Pendyala, Heather Z Huang, Anthony Cooke, Dana Jackson, Raymond J. Monnat, Douglas M. Fowler, Zachary Krieger
Microscopy is a powerful tool for characterizing complex cellular phenotypes, but linking these phenotypes to genotype or RNA expression at scale remains challenging. Here, we present Visual Cell Sorting, a method that physically separates hundreds o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b135481a550cae94e26ba9baa2c7dae
Autor:
Kenneth A. Matreyek, Douglas M. Fowler, Nicholas Hasle, Melissa A Chiasson, Jason J. Stephany
Publikováno v:
Nucleic Acids Research
Multiplex genetic assays can simultaneously test thousands of genetic variants for a property of interest. However, limitations of existing multiplex assay methods in cultured mammalian cells hinder the breadth, speed and scale of these experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278bfcf663874293feffe57620961d3c
https://doi.org/10.1093/nar/gkz910
https://doi.org/10.1093/nar/gkz910
Publikováno v:
Cold Spring Harb Perspect Med
Phosphatase and tensin homolog (PTEN) is a tumor suppressor that directly regulates a diverse array of cellular phenotypes, including growth, migration, morphology, and genome stability. How a single protein impacts so many important cellular process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a2dc29b4feac3ddb60c80a12ef8cc5c
https://pubmed.ncbi.nlm.nih.gov/31451538
https://pubmed.ncbi.nlm.nih.gov/31451538
Autor:
Nicholas Hasle, Miriam Williamson, Floriane Z. Ngako Kameni, Katherine A. Sitko, Jason J. Stephany, Douglas M. Fowler, Vanessa E. Gray
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 11, Pp 3683-3689 (2019)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
Despite the importance of Aβ aggregation in Alzheimer’s disease etiology, our understanding of the sequence determinants of aggregation is sparse and largely derived from in vitro studies. For example, in vitro proline and alanine scanning mutagen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa50404cc29df5080dedd698a35a95ce
Publikováno v:
Cold Spring Harbor Perspectives in Medicine. 9:a036228
Phosphatase and tensin homolog (PTEN) is a tumor suppressor that directly regulates a diverse array of cellular phenotypes, including growth, migration, morphology, and genome stability. How a single protein impacts so many important cellular process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcb47b76e9afbdecc5d567b6109c3c38
https://doi.org/10.1101/cshperspect.a036228
https://doi.org/10.1101/cshperspect.a036228
Autor:
Nicholas Hasle, Savitha Kalidas, Mehdi Labaied, Margaret A. Phillips, Igor Cestari, Kenneth Stuart, Severine Monnerat, Qiong Li, Marilyn Parsons, Sandesh Regmi
Publikováno v:
Eukaryotic cell. 13(4)
Human African trypanosomiasis (HAT) is an important public health threat in sub-Saharan Africa. Current drugs are unsatisfactory, and new drugs are being sought. Few validated enzyme targets are available to support drug discovery efforts, so our goa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::040dad4bac477eaeae9c9375dbc63c58
https://pubmed.ncbi.nlm.nih.gov/24562907
https://pubmed.ncbi.nlm.nih.gov/24562907
Autor:
Megan M. Maurano, Thomas D. Bird, Nicholas Hasle, Gregory S. Olson, Marshall S. Horwitz, Jay Shendure, Max L. Dougherty, John Lazar, Desiree A. Marshall, Karina Diaz, Theodore A Gobillot, Maria T. Nelson, Eli Grunblatt, Jason C. Klein, Daniel J. P. Lawrence, C. Dirk Keene, Sanjay Srivatsan
Publikováno v:
Cold Spring Harbor Molecular Case Studies
Adult-onset Niemann–Pick disease type C (NPC) is an infrequent presentation of a rare neurovisceral lysosomal lipid storage disorder caused by autosomal recessive mutations in NPC1 (∼95%) or NPC2 (∼5%). Our patient was diagnosed at age 33 when
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311b56761b18634466e92e040b6437ad
https://doi.org/10.1101/mcs.a001222
https://doi.org/10.1101/mcs.a001222
Autor:
Karen Sommer, Jordan Jarjour, Jaya Sahni, Malika Hale, Baeckseung Lee, David J. Rawlings, Alexandra E. Grier, Guillermo S. Romano Ibarra, Nicholas Hasle, Honaker Yuchi Chiang, Andrew M. Scharenberg, Iram F. Khan, Alexander Astrakhan
Publikováno v:
Molecular Therapy. 24:S158
In current clinical trials, delivery of an anti-cancer chimeric antigen receptor (CAR) to patient T cells is accomplished using randomly integrating retroviruses. Designer nucleases and AAV donor templates allow an alternative delivery method that in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6201e2363642fd02881a03ec262e10e
https://doi.org/10.1016/s1525-0016(16)33207-5
https://doi.org/10.1016/s1525-0016(16)33207-5