Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Nicholas H F, Fine"'
Autor:
Julia Ast, Daniela Nasteska, Nicholas H. F. Fine, Daniel J. Nieves, Zsombor Koszegi, Yann Lanoiselée, Federica Cuozzo, Katrina Viloria, Andrea Bacon, Nguyet T. Luu, Philip N. Newsome, Davide Calebiro, Dylan M. Owen, Johannes Broichhagen, David J. Hodson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Visualizing endogenous GPCRs is challenging. Here the authors generate mice with an enzyme self-label genome-edited into the endogenous glucagon-like peptide-1 receptor locus, design fluorescent dyes for specific labelling in complex tissue, and reve
Externí odkaz:
https://doaj.org/article/a1c114f010cf4dc7bafcaf994b474beb
Autor:
Daniela Nasteska, Nicholas H. F. Fine, Fiona B. Ashford, Federica Cuozzo, Katrina Viloria, Gabrielle Smith, Aisha Dahir, Peter W. J. Dawson, Yu-Chiang Lai, Aimée Bastidas-Ponce, Mostafa Bakhti, Guy A. Rutter, Remi Fiancette, Rita Nano, Lorenzo Piemonti, Heiko Lickert, Qiao Zhou, Ildem Akerman, David J. Hodson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Beta cell subpopulations with low expression in PDX1, MAFA, and insulin might contribute to islet function and insulin release. Here the authors show that altering the proportion of PDX1LOW MAFALOW to PDX1HIGH MAFAHIGH cells impairs islet function.
Externí odkaz:
https://doaj.org/article/cf504598ffd644018cbb1c9c1fc2bf2c
Autor:
Julia Ast, Anastasia Arvaniti, Nicholas H. F. Fine, Daniela Nasteska, Fiona B. Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J. Jones, Maria A. Lucey, Shugo Sasaki, Daniel I. Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D’Agostino, Frank Reimann, Francis C. Lynn, Christopher A. Reissaus, Amelia K. Linnemann, Elisa D’Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Podewin, Johannes Broichhagen, David J. Hodson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Glucagon-like peptide-1 receptor is an important regulator of appetite and glucose homeostasis. Here the authors describe super-resolution microscopy and in vivo imaging compatible fluorescent probes, which reveal endogenous glucagon-like peptide-1 r
Externí odkaz:
https://doaj.org/article/1bec881e08194ff3b4ad84658e067529
Autor:
Sophie L. Allen, Alex P. Seabright, Jonathan I. Quinlan, Amritpal Dhaliwal, Felicity R. Williams, Nicholas H. F. Fine, David J. Hodson, Matthew J. Armstrong, Ahmed M. Elsharkaway, Carolyn A. Greig, Yu-Chiang Lai, Janet M. Lord, Gareth G. Lavery, Leigh Breen
Publikováno v:
Cells, Vol 11, Iss 7, p 1098 (2022)
Sarcopenia is a common complication affecting liver disease patients, yet the underlying mechanisms remain unclear. We aimed to elucidate the cellular mechanisms that drive sarcopenia progression using an in vitro model of liver disease. C2C12 myotub
Externí odkaz:
https://doaj.org/article/d7df7ae34fcb440ab7482dd7ac5fbac2
Autor:
Tom Podewin, Julia Ast, Johannes Broichhagen, Nicholas H. F. Fine, Daniela Nasteska, Philipp Leippe, Manuel Gailer, Teresa Buenaventura, Nisha Kanda, Ben J. Jones, Celine M’Kadmi, Jean-Louis Baneres, Jacky Marie, Alejandra Tomas, Dirk Trauner, Anja Hoffmann-Röder, David J. Hodson
Publikováno v:
ACS Central Science, Vol 4, Iss 2, Pp 166-179 (2018)
Externí odkaz:
https://doaj.org/article/f8c0f33ccd2442baa687d32ec11cefda
Autor:
Daniela Nasteska, Nicholas H. F. Fine, Fiona B. Ashford, Federica Cuozzo, Katrina Viloria, Gabrielle Smith, Aisha Dahir, Peter W. J. Dawson, Yu-Chiang Lai, Aimée Bastidas-Ponce, Mostafa Bakhti, Guy A. Rutter, Remi Fiancette, Rita Nano, Lorenzo Piemonti, Heiko Lickert, Qiao Zhou, Ildem Akerman, David J. Hodson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/babcfb71b6f54a778b28993243b49eed
Autor:
Julia Ast, Anastasia Arvaniti, Nicholas H. F. Fine, Daniela Nasteska, Fiona B. Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J. Jones, Maria A. Lucey, Shugo Sasaki, Daniel I. Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D’Agostino, Frank Reimann, Francis C. Lynn, Christopher A. Reissaus, Amelia K. Linnemann, Elisa D’Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Podewin, Johannes Broichhagen, David J. Hodson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/ec33e8108ee44445a3672afb9f0516cc
Autor:
Alex Montoya, Emirhan Tasoez, Holger Kramer, Olof Idevall-Hagren, S Neda Mousavy Gharavy, Steven Millership, Mark Ibberson, Ming Hu, Aida Martinez-Sanchez, Paul Gadue, Eleni Georgiadou, Isabelle Leclerc, Dominic J. Withers, Nikolay Ninov, Bryn M. Owen, Pauline Chabosseau, Grazia Pizza, David A. Jacobson, Matthew T. Dickerson, Fabian L. Cardenas-Diaz, Zenobia B. Mehta, Marianne Voz, Christophe Magnan, Céline Cruciani-Guglielmacci, Nicholas H. F. Fine, Guy A. Rutter
Publikováno v:
Diabetologia
Diabetologia, 2021, 64 (4), pp.850-864. ⟨10.1007/s00125-020-05350-x⟩
Diabetologia, 2021, 64 (4), pp.850-864. ⟨10.1007/s00125-020-05350-x⟩
Aims/hypothesis Variants close to the VPS13C/C2CD4A/C2CD4B locus are associated with altered risk of type 2 diabetes in genome-wide association studies. While previous functional work has suggested roles for VPS13C and C2CD4A in disease development,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3515d1e5f62db8cf8036e2aa24a6876b
http://europepmc.org/articles/PMC7829492
http://europepmc.org/articles/PMC7829492
Autor:
Shugo Sasaki, Julia Ast, Daniela Nasteska, Fiona B. Ashford, Andrea Bacon, Zania Stamataki, Tom Podewin, Alejandra Tomas, Nicholas H. F. Fine, David J. Hodson, Giuseppe D'Agostino, Maria Lucey, Elisa D’Este, Christopher A. Reissaus, Amelia K. Linnemann, Stefan Trapp, Zsombor Koszegi, Johannes Broichhagen, Ben Jones, Kai Johnsson, Daniel I. Brierley, Francis C. Lynn, Benoit Hastoy, Anastasia Arvaniti, Frank Reimann, Davide Calebiro
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Ast, J, Arvaniti, A, Fine, N H F, Nasteska, D, Ashford, F B, Stamataki, Z, Koszegi, Z, Bacon, A, Jones, B J, Lucey, M A, Sasaki, S, Brierley, D I, Hastoy, B, Tomas, A, D'Agostino, G, Reimann, F, Lynn, F C, Reissaus, C A, Linnemann, A K, D'Este, E, Calebiro, D, Trapp, S, Johnsson, K, Podewin, T, Broichhagen, J & Hodson, D J 2020, ' Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics ', Nature Communications, vol. 11, no. 1, 467, pp. 467 . https://doi.org/10.1038/s41467-020-14309-w
Nature Communications
Ast, J, Arvaniti, A, Fine, N H F, Nasteska, D, Ashford, F B, Stamataki, Z, Koszegi, Z, Bacon, A, Jones, B J, Lucey, M A, Sasaki, S, Brierley, D I, Hastoy, B, Tomas, A, D'Agostino, G, Reimann, F, Lynn, F C, Reissaus, C A, Linnemann, A K, D'Este, E, Calebiro, D, Trapp, S, Johnsson, K, Podewin, T, Broichhagen, J & Hodson, D J 2020, ' Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics ', Nature Communications, vol. 11, no. 1, 467, pp. 467 . https://doi.org/10.1038/s41467-020-14309-w
The glucagon-like peptide-1 receptor (GLP1R) is a class B G protein-coupled receptor (GPCR) involved in metabolism. Presently, its visualization is limited to genetic manipulation, antibody detection or the use of probes that stimulate receptor activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39bcef7b82d9b4f5c53076b4bcbaa9a
http://link.springer.com/article/10.1038/s41467-020-14309-w
http://link.springer.com/article/10.1038/s41467-020-14309-w
Autor:
Ramona Birke, Kilian Roßmann, Julia Ast, Bettina Mathes, Johannes Broichhagen, Ben Jones, Nicholas H. F. Fine, Jenny Eichhorst, Alissa Novak, T. Podewin, Amelia K. Linnemann, Alejandra Tomas, David J. Hodson, Martin Lehmann
Publikováno v:
ChemRxiv
The glucagon-like peptide-1 receptor (GLP1R) is expressed in peripheral tissues and the brain, where it exerts pleiotropic actions on metabolic and inflammatory processes. Detection and visualization of GLP1R remains challenging, partly due to a lack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fad5010452f8fff3074bfea8071aad5
https://chemrxiv.org/engage/chemrxiv/article-details/60ff0d5a393cc904c94f1f18
https://chemrxiv.org/engage/chemrxiv/article-details/60ff0d5a393cc904c94f1f18
