Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Nicholas Gaiano"'
Autor:
Charles G. Eberhart, Nicholas Gaiano, Eli E. Bar, Vidya Gopalakrishnan, Luigi Marchionni, Pete Taylor, Karisa C. Schreck
Purpose: Multiple developmental pathways including Notch, Hedgehog, and Wnt are active in malignant brain tumors such as medulloblastoma and glioblastoma (GBM). This raises the possibility that tumors might compensate for therapy directed against one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bfd89cb6d5083386ef5edde0de0edad
https://doi.org/10.1158/1078-0432.c.6519335
https://doi.org/10.1158/1078-0432.c.6519335
Autor:
Charles G. Eberhart, Nicholas Gaiano, Eli E. Bar, Vidya Gopalakrishnan, Luigi Marchionni, Pete Taylor, Karisa C. Schreck
Supplementary Figures S1-S3; Supplementary Tables S1-S2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb999221d01c5f548b77fc32d0895d5
https://doi.org/10.1158/1078-0432.22442660.v1
https://doi.org/10.1158/1078-0432.22442660.v1
Autor:
Charles G. Eberhart, Nicholas Gaiano, Laura Asnaghi, Louis Dang, Karisa C. Schreck, Tarran J. Pierfelice
Supplementary Figure 1 from Notch3 Activation Promotes Invasive Glioma Formation in a Tissue Site-Specific Manner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad149d8083e8b760163a06dcd4d3980e
https://doi.org/10.1158/0008-5472.22386833
https://doi.org/10.1158/0008-5472.22386833
Autor:
Charles G. Eberhart, Nicholas Gaiano, Laura Asnaghi, Louis Dang, Karisa C. Schreck, Tarran J. Pierfelice
Supplementary Figure Legend from Notch3 Activation Promotes Invasive Glioma Formation in a Tissue Site-Specific Manner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef7e21390a6ec69ea8ed0014afa0d57
https://doi.org/10.1158/0008-5472.22386830.v1
https://doi.org/10.1158/0008-5472.22386830.v1
Publikováno v:
Genes to Cells. 20:706-719
In addition to its well-established role during immune system function, NF-κB regulates cell survival and synaptic plasticity in the mature nervous system. Here, we show that during mouse brain development, NF-κB activity is present in the neocorti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974b2bf6051c4f2a7ed51ad9fb6e1305
https://doi.org/10.1111/gtc.12267
https://doi.org/10.1111/gtc.12267
Publikováno v:
Hippocampus. 25:670-678
Activation of the Notch pathway in neurons is essential for learning and memory in various species from invertebrates to mammals. However, it remains unclear how Notch signaling regulates neuronal plasticity, and whether the transcriptional regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1f9b3db0a9ac056c2968fac9025fdfc
https://doi.org/10.1002/hipo.22402
https://doi.org/10.1002/hipo.22402
Publikováno v:
Genes & Development. 25:1399-1411
Blood vessel networks are typically formed by angiogenesis, a process in which new vessels form by sprouting of endothelial cells from pre-existing vessels. This process is initiated by vascular endothelial growth factor (VEGF)-mediated tip cell sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b5da002f3cef0053a6ce453a06d80a
https://doi.org/10.1101/gad.2042011
https://doi.org/10.1101/gad.2042011
Autor:
Louis T. Dang, Charles G. Eberhart, Tarran J. Pierfelice, Nicholas Gaiano, Karisa C. Schreck, Laura Asnaghi
Publikováno v:
Cancer Research. 71:1115-1125
Although Notch signaling has been widely implicated in neoplastic growth, direct evidence for in vivo initiation of neoplasia by the pathway in murine models has been limited to tumors of lymphoid, breast, and choroid plexus cells. To examine tumorig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b63374dd23022499f9d1e81560d7c8a
https://doi.org/10.1158/0008-5472.can-10-0690
https://doi.org/10.1158/0008-5472.can-10-0690
Autor:
Sean C. Goetsch, Jay W. Schneider, Eric N. Olson, Nicholas Gaiano, Joseph A. Hill, Jamie Russell
Publikováno v:
Circulation Research. 108:51-59
Rationale: Transgenic Notch reporter mice express enhanced green fluorescent protein in cells with C-promoter binding factor-1 response element transcriptional activity (CBF1-RE x4 -EGFP), providing a unique and powerful tool for identifying and isol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c83d461fc64b28d13b40ff5fe22fdadf
https://doi.org/10.1161/circresaha.110.233262
https://doi.org/10.1161/circresaha.110.233262
Autor:
Dawn E. Watkins-Chow, Karisa C. Schreck, Anthony Burnetti, Hungjiun Liaw, Denise M. Larson, Christopher A. Walsh, Tarran J. Pierfelice, William J. Pavan, Kyungjae Myung, Debra L. Silver, Nicholas Gaiano
Publikováno v:
Nature neuroscience
Summary Brain structure and size requires precise division of neural stem cells (NSCs), which self-renew and generate intermediate neural progenitors (INPs) and neurons. The factors that regulate NSCs remain poorly understood, as do mechanistic expla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d955ef9278fff6b6478c93779ed17869
https://doi.org/10.1038/nn.2527
https://doi.org/10.1038/nn.2527