Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Nicholas G. Selner"'
Autor:
Ziqing Qian, Roger Briesewitz, Dehua Pei, Zhengrong Wu, Punit Upadhyaya, Nicholas G. Selner, Sarah R. Clippinger
Publikováno v:
Angewandte Chemie International Edition. 54:7602-7606
Ras genes are frequently activated in human cancers, but the mutant Ras proteins remain largely "undruggable" through the conventional small-molecule approach owing to the absence of any obvious binding pockets on their surfaces. By screening a combi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5444a8d4a2c476d86ce8970829c2117
https://doi.org/10.1002/anie.201502763
https://doi.org/10.1002/anie.201502763
Autor:
Dehua Pei, Rinrada Luechapanichkul, Jonathan R. LaRochelle, Bisheng Jiang, Ryan L. Hard, Wenlong Lian, Ziqing Qian, Nicholas G. Selner, Amy M. Barrios
Publikováno v:
Biochemistry
Cyclic heptapeptide cyclo(FΦRRRRQ) (cFΦR4, where Φ is l-2-naphthylalanine) was recently found to be efficiently internalized by mammalian cells. In this study, its mechanism of internalization was investigated by perturbing various endocytic event
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c918ca90847721d56b6afc1f8c2cf822
https://doi.org/10.1021/bi5004102
https://doi.org/10.1021/bi5004102
Autor:
Michael C. Ostrowski, Amy Webb, Nicholas G. Selner, Resham Saeed, Thierry Pécot, Cynthia Timmers, Vincenzo Coppola, Gustavo Leone, Maria C. Cuitiño, Michele Pagano, Tom Liu, Daokun Sun, Antonio J. Perez-Castro, Soo In Bae, Raleigh D. Kladney, Linda Clijsters, Neelam Shinde, Takayuki Okano-Uchida
Publikováno v:
Cell Reports, Vol 27, Iss 12, Pp 3547-3560.e5 (2019)
Summary: Orchestrating cell-cycle-dependent mRNA oscillations is critical to cell proliferation in multicellular organisms. Even though our understanding of cell-cycle-regulated transcription has improved significantly over the last three decades, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ccbcf945651c601a952157900993aa5
https://doi.org/10.1016/j.celrep.2019.05.004
https://doi.org/10.1016/j.celrep.2019.05.004
Autor:
Xianwen Chen, Charles E. Bell, Zhong Yin Zhang, Rinrada Luechapanichkul, Benjamin G. Neel, Stefan Knapp, Dehua Pei, Nicholas G. Selner
The sequence selectivity of 14 classical protein-tyrosine phosphatases (PTPs) (PTPRA, PTPRB, PTPRC, PTPRD, PTPRO, PTP1B, SHP-1, SHP-2, HePTP, PTP-PEST, TCPTP, PTPH1, PTPD1, and PTPD2) was systematically profiled by screening their catalytic domains a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5845e40ae59d23c79bbc0f2f070bc24
https://doi.org/10.1021/bi401223r
https://doi.org/10.1021/bi401223r
Autor:
Dehua Pei, Tiffany M. Meyer, Caterina Iorio, Anne-Sophie Wavreille, Rinrada Luechapanichkul, Richard Chan, Benjamin G. Neel, Lige Ren, Xiang Zhou, Nicholas G. Selner, Xianwen Chen
Publikováno v:
Biochemistry. 50:2339-2356
We determined the substrate specificities of the protein tyrosine phosphatases (PTPs) PTP1B, RPTPα, SHP-1, and SHP-2 by on-bead screening of combinatorial peptide libraries and solution-phase kinetic analysis of individually synthesized phosphotyros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da13c34231af0cd6b025d74fb47695ba
https://doi.org/10.1021/bi1014453
https://doi.org/10.1021/bi1014453