Výsledky vyhledávání - "Nicholas G. M. Wells"

Predicting binding affinity changes from long-distance mutations using MD simulations and Rosetta

Autor: Nicholas G. M. Wells, Colin A. Smith

Computationally modeling how mutations affect protein-protein binding not only helps uncover the biophysics of protein interfaces, but also enables the redesign and optimization of protein interactions. Traditional high-throughput methods for estimat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a108967f139a86d079e4653982689713
https://doi.org/10.1101/2022.04.26.489494

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Free energy calculations of ALS‐causing SOD1 mutants reveal common perturbations to stability and dynamics along the maturation pathway

Autor: Colin A. Smith, Grant A. Tillinghast, Nicholas G. M. Wells, Alison L. O'Neil

Publikováno v: Protein Sci

With over 150 heritable mutations identified as disease-causative, superoxide dismutase 1 (SOD1) has been a main target of amyotrophic lateral sclerosis (ALS) research and therapeutic efforts. However, recent evidence has suggested that neither loss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eba91470c310506810a8f4410f8c590
https://europepmc.org/articles/PMC8376412/

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