Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nicholas G. Lamson"'
Autor:
Nicholas G. Lamson, Andrew J. Pickering, Jeffrey Wyckoff, Priya Ganesh, Elizabeth A. Calle, Joelle P. Straehla, Paula T. Hammond
Publikováno v:
Bioengineering & Translational Medicine, Vol 9, Iss 4, Pp n/a-n/a (2024)
Abstract Drug‐carrying nanoparticles are a promising strategy to deliver therapeutics into the brain, but their translation requires better characterization of interactions between nanomaterials and endothelial cells of the blood–brain barrier (B
Externí odkaz:
https://doaj.org/article/02127fd78b2d417a89e33a918f78b3dd
Long‐term daily oral administration of intestinal permeation enhancers is safe and effective in mice
Autor:
Katherine C. Fein, John P. Gleeson, Kyle Cochran, Nicholas G. Lamson, Rose Doerfler, Jilian R. Melamed, Kathryn A. Whitehead
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 1, Pp n/a-n/a (2023)
Abstract Although protein drugs are powerful biologic therapeutics, they cannot be delivered orally because their large size and hydrophilicity limit their absorption across the intestinal epithelium. One potential solution is the incorporation of pe
Externí odkaz:
https://doaj.org/article/85b4c567bc5744c5b8b5653f55eff395
Publikováno v:
PeerJ, Vol 8, p e8681 (2020)
Background Inflammatory bowel disease (IBD) is a family of debilitating disorders that affects more than 1 million people in the United States. Many animal studies of IBD use a dextran sulfate sodium (DSS) mouse model of colitis that induces rapid an
Externí odkaz:
https://doaj.org/article/a86e021418564e82b863269b8e820ecc
Autor:
Nicholas G. Lamson, Andrew J. Pickering, Jeffrey Wyckoff, Priya Ganesh, Joelle P. Straehla, Paula T. Hammond
Development of new treatments for neurological disorders, especially brain tumors and neurodegenerative diseases, is hampered by poor accumulation of new therapeutic candidates in the brain. Drug carrying nanoparticles are a promising strategy to del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15141c95911d12de4ca69f01b437d37f
https://doi.org/10.1101/2022.10.31.514595
https://doi.org/10.1101/2022.10.31.514595
Long‐term daily oral administration of intestinal permeation enhancers is safe and effective in mice
Autor:
Katherine C. Fein, John P. Gleeson, Kyle Cochran, Nicholas G. Lamson, Rose Doerfler, Jilian R. Melamed, Kathryn A. Whitehead
Publikováno v:
Bioengineering & Translational Medicine. 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5de1924f4bd4bf541acfc1c41c44c34c
https://doi.org/10.1002/btm2.10342
https://doi.org/10.1002/btm2.10342
A Potent Branched-Tail Lipid Nanoparticle Enables Multiplexed mRNA Delivery and Gene Editing In Vivo
Autor:
Rebecca L. Ball, Jilian R. Melamed, Khalid A. Hajj, Kathryn A. Whitehead, Namit Chaudhary, Saigopalakrishna S. Yerneni, Nicholas G. Lamson
Publikováno v:
Nano Lett
The clinical translation of messengerRNA (mRNA) drugs has been slowed by a shortage of delivery vehicles that potently and safely shuttle mRNA into target cells. Here, we describe the properties of a particularly potent branched-tail lipid nanopartic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde8978d38cf37c2e9276c563ab3ea4a
https://doi.org/10.1021/acs.nanolett.0c00596
https://doi.org/10.1021/acs.nanolett.0c00596
Autor:
Katherine C. Fein, Shiyuan Zheng, Kathryn A. Whitehead, Nicholas G. Lamson, Kris Noel Dahl, Kirill Lavrenyuk
Publikováno v:
ACS Biomaterials Science & Engineering. 6:367-374
A major obstacle for topical and enteral drug delivery is the poor transport of macromolecular drugs through the epithelium. One potential solution is the use of permeation enhancers that alter epithelial structures. Piperazine derivatives are known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f4ccd2b81d1ca88d3db587a7587f78
https://doi.org/10.1021/acsbiomaterials.9b01660
https://doi.org/10.1021/acsbiomaterials.9b01660
Autor:
Tejal A. Desai, Karen E. Samy, Deanna L. Kroetz, Kathryn A. Whitehead, Elizabeth S. Levy, Nicholas G. Lamson
Publikováno v:
Eur J Pharm Biopharm
Oral drug delivery is a preferred administration route due to its low cost, high patient compliance and fewer adverse events compared to intravenous administration. However, many pharmaceuticals suffer from poor solubility and low oral bioavailabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5baf4f59cc64eb8772f9672804d646
https://doi.org/10.1016/j.ejpb.2019.10.007
https://doi.org/10.1016/j.ejpb.2019.10.007
Publikováno v:
Nature Biomedical Engineering. 4:84-96
The oral delivery of bioactive peptides and proteins is prevented by the intestinal epithelial barrier, in which intercellular tight junction complexes block the uptake of macromolecules. Here we show that anionic nanoparticles induce tight junction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fe5fab2c042e28a10f4fd97991b1f52
https://doi.org/10.1038/s41551-019-0465-5
https://doi.org/10.1038/s41551-019-0465-5
Autor:
Alexandra N. Newby, Katherine C. Fein, Ahuja, Kolodieznyi D, Xian S, Kathryn A. Whitehead, Rebecca L. Ball, Zhang A, Berger A, Brigitte F. Schmidt, John P. Gleeson, Nicholas G. Lamson, Melamed, Silva Gl, Namit Chaudhary, Kanika Suri, Cochran K
Although oral drug delivery is preferred by patients, it is not possible for proteins because the gastrointestinal tract is not sufficiently permeable. To enable the non-toxic oral uptake of protein drugs, we investigated plant-based foods as intesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f50fc3ca49eb64bd226f07bfc41e42
https://doi.org/10.1101/2020.03.11.987461
https://doi.org/10.1101/2020.03.11.987461