Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Nicholas G Spencer"'
Mechanisms Underlying Interferon-γ-Induced Priming of Microglial Reactive Oxygen Species Production.
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162497 (2016)
Microglial priming and enhanced reactivity to secondary insults cause substantial neuronal damage and are hallmarks of brain aging, traumatic brain injury and neurodegenerative diseases. It is, thus, of particular interest to identify mechanisms invo
Externí odkaz:
https://doaj.org/article/359418bb6bb4496cb836372666c7472c
Autor:
Michael J. D. Daniels, Jack Rivers-Auty, Tom Schilling, Nicholas G. Spencer, William Watremez, Victoria Fasolino, Sophie J. Booth, Claire S. White, Alex G. Baldwin, Sally Freeman, Raymond Wong, Clare Latta, Shi Yu, Joshua Jackson, Nicolas Fischer, Violette Koziel, Thierry Pillot, James Bagnall, Stuart M. Allan, Pawel Paszek, James Galea, Michael K. Harte, Claudia Eder, Catherine B. Lawrence, David Brough
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
NSAID-induced analgesia is typically induced by inhibition of COX enzymes. Here the authors show instead that fenamate NSAIDs inhibit the Nlrp3 inflammasome via an effect on volume-regulated anion channel function and also repurpose these drugs for t
Externí odkaz:
https://doaj.org/article/dca8360eb57c4ee588985f6c192c8a0c
Publikováno v:
Magma (New York, N.y.)
MAGMA Magnetic Resonance Materials in Physics, Biology and Medicine
MAGMA Magnetic Resonance Materials in Physics, Biology and Medicine
Objectives In the present study, we have tested whether MRI T1 relaxation time is a sensitive marker to detect early stages of amyloidosis and gliosis in the young 5xFAD transgenic mouse, a well-established animal model for Alzheimer’s disease. Mat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a189ad0673d03099010d8c55590d7d7
https://doi.org/10.1007/s10334-016-0593-9
https://doi.org/10.1007/s10334-016-0593-9
Publikováno v:
Neuropeptides. 53:63-70
MRI contrast agents, containing peptide sequences that bind β-amyloid and gadolinium ions ligated to DOTA have been synthesized for evaluation in early diagnosis of Alzheimer's Disease in transgenic mice models. A number of brain penetration modific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e998d3d046f05a02b66a70f8061d63f
https://doi.org/10.1016/j.npep.2015.07.001
https://doi.org/10.1016/j.npep.2015.07.001
Autor:
K. Amir, K. Elderfield, L. R. Bridges, Nicholas G. Spencer, Brian M. Austen, Franklyn A. Howe
Publikováno v:
NeuroImage. 76
Assessment of β-amyloid (Aβ) plaque load in Alzheimer's disease by MRI would provide an important biomarker to monitor disease progression or treatment response. Alterations in tissue structure caused by the presence of Aβ may cause localised chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa0cff244f512068ccfcdc6ad238fa4
https://pubmed.ncbi.nlm.nih.gov/23507393
https://pubmed.ncbi.nlm.nih.gov/23507393
Publikováno v:
NMR in biomedicine. 23(2)
The aim of this work was to investigate the effect of experimental conditions on the visibility of polyamines. In solution the chemical shift of the three groups of peaks (at approximately 1.8, 2.1 and 3.1 ppm) were found to be pH dependent. Relaxati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926ed20f48e2d053bbc6debf9006022c
https://pubmed.ncbi.nlm.nih.gov/19757478
https://pubmed.ncbi.nlm.nih.gov/19757478