Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Nicholas G James"'
Autor:
Shihai Zhang, Huanyu Wang, Chase H Melick, Mi-Hyeon Jeong, Adna Curukovic, Shweta Tiwary, Tshering D Lama-Sherpa, Delong Meng, Kelly A Servage, Nicholas G James, Jenna L Jewell
Publikováno v:
PLoS Genetics, Vol 17, Iss 10, p e1009832 (2021)
The mammalian target of rapamycin complex 1 (mTORC1) senses multiple stimuli to regulate anabolic and catabolic processes. mTORC1 is typically hyperactivated in multiple human diseases such as cancer and type 2 diabetes. Extensive research has focuse
Externí odkaz:
https://doaj.org/article/358b3427813548ef951b4b856085d782
Autor:
Jonathan B. Lynch, Daisuke Takagi, Nicholas G. James, Sangwoo Shin, Edward G. Ruby, Margaret J. McFall-Ngai
Publikováno v:
Biophys J
Symbiotic bacteria often navigate complex environments before colonizing privileged sites in their host organism. Chemical gradients are known to facilitate directional taxis of these bacteria, guiding them towards their eventual destination. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288d9e714fd951fa528ebe551327acb2
https://doi.org/10.1016/j.bpj.2022.04.008
https://doi.org/10.1016/j.bpj.2022.04.008
Autor:
Bethany J. Sanstrum, Brandee M. S. S. Goo, Diana Z. Y. Holden, Donovan D. Delgado, Thien P. N. Nguyen, Kiana D. Lee, Nicholas G. James
Publikováno v:
Molecules, Vol 25, Iss 11, p 2561 (2020)
Mutations within the Leucine-Rich Repeat Kinase 2 (LRRK2) gene are the most common genetic cause of autosomal and sporadic Parkinson’s disease (PD). LRRK2 is a large multidomain kinase that has reported interactions with several membrane proteins,
Externí odkaz:
https://doaj.org/article/a14a1f3dac674d79b6c483523946058e
Autor:
Ron S. Broide, Birgitte S. Jacky, Amy Brideau-Andersen, Catherine Rheaume, David M. Jameson, Nicholas G. James, Bethany J. Sanstrum, Shiazah Z. Malik
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Clostridium botulinum neurotoxin serotype A (BoNT/A) is a potent neurotoxin that serves as an effective therapeutic for several neuromuscular disorders via induction of temporary muscular paralysis. Specific binding and internalization of BoNT/A into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d4a9eb2a4748f04d9486588f007e80
https://doaj.org/article/b42c13adfc0c41cca508116cf7c6999f
https://doaj.org/article/b42c13adfc0c41cca508116cf7c6999f
Autor:
Hiroaki Akamatsu, Carlos L. Arteaga, Alberto Servetto, Angel Guerrero-Zotano, Dhivya R. Sudhan, Saurabh Mendiratta, Sumanta Chatterjee, Paula I. Gonzalez-Ericsson, Nicholas G. James, Kyungmin Lee, Rahul K. Kollipara, Luigi Formisano, Ralf Kittler, Chang-Ching Lin, Ariella B. Hanker
Publikováno v:
Cancer Research. 81:GS1-06
Background: FGFR1 amplification occurs in ~ 15% of ER+ breast cancers. In these tumors, nuclear FGFR1 has been shown to interact with DNA, but its role in transcriptional regulation is unclear. Thus, we investigated the genomic role of FGFR1 in ER+/F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a46ecb22dcd48f0c91423e40be337eee
https://doi.org/10.1158/1538-7445.sabcs20-gs1-06
https://doi.org/10.1158/1538-7445.sabcs20-gs1-06
Autor:
Per Niklas Hedde, Barbara Barylko, Chi-Li Chiu, Joseph P. Albanesi, David M. Jameson, Nicholas G. James
Mutations in dynamin 2 (DNM2) have been associated with two distinct motor disorders, Charcot-Marie-Tooth neuropathies (CMT) and centronuclear myopathy (CNM). The majority of these mutations are clustered in the pleckstrin homology domain (PHD) which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e119d098ba018d1dc0637276f7f7d017
https://doi.org/10.1101/2021.12.13.472395
https://doi.org/10.1101/2021.12.13.472395
Autor:
Shweta Tiwary, Tshering D. Lama-Sherpa, Delong Meng, Shihai Zhang, Jenna L. Jewell, Nicholas G. James, Mi Hyeon Jeong, Chase H. Melick, Adna Curukovic, Huanyu Wang, Kelly A. Servage
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 10, p e1009832 (2021)
PLoS Genetics, Vol 17, Iss 10, p e1009832 (2021)
The mammalian target of rapamycin complex 1 (mTORC1) senses multiple stimuli to regulate anabolic and catabolic processes. mTORC1 is typically hyperactivated in multiple human diseases such as cancer and type 2 diabetes. Extensive research has focuse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a684702ef1d317e7e86038ccd65c13f
http://europepmc.org/articles/PMC8570464
http://europepmc.org/articles/PMC8570464
Autor:
Tara C. Tassin, Barbara Barylko, Per Niklas Hedde, Yan Chen, Derk D. Binns, Nicholas G. James, Joachim D. Mueller, David M. Jameson, Ronald Taussig, Joseph P. Albanesi
Publikováno v:
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Mutations in the gene encoding dynamin 2 (DNM2), a GTPase that catalyzes membrane constriction and fission, are associated with two autosomal-dominant motor disorders, Charcot-Marie-Tooth disease (CMT) and centronuclear myopathy (CNM), which affect n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec69c1974dfaf9493962bdf58fb13fef
https://pubmed.ncbi.nlm.nih.gov/34744632
https://pubmed.ncbi.nlm.nih.gov/34744632
Autor:
Junmei Zhang, Jenna L. Jewell, Adna Curukovic, Nicholas G. James, Qianmei Yang, Ting Sung Hsieh, Mi Hyeon Jeong, Chase H. Melick, Delong Meng, Brenden C. Park
Publikováno v:
The EMBO Journal
The mammalian target of rapamycin complex 1 (mTORC1) integrates nutrients, growth factors, stress, and energy status to regulate cell growth and metabolism. Amino acids promote mTORC1 lysosomal localization and subsequent activation. However, the sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25f74564a5fe08dae749cb2d5ef238b
http://europepmc.org/articles/PMC8204869
http://europepmc.org/articles/PMC8204869
Publikováno v:
BioDesign Research, Vol 2021 (2021)
Many cells possess the ability to engulf and incorporate particles by phagocytosis. This active process is characteristic of microorganisms as well as higher order species. In mammals, monocytes, macrophages and microglia are among so-called professi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017f1b0c8ad53609e99c5c40468db4d8
https://doaj.org/article/0dcd32c8b4d64611854320dfd896e08a
https://doaj.org/article/0dcd32c8b4d64611854320dfd896e08a