Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Nicholas G, Jendzjowsky"'
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-8 (2021)
Abstract The carotid bodies are multimodal sensors that regulate various autonomic reflexes. Recent evidence demonstrates their role in immune reflex regulation. Our previous studies using the allergen (ovalbumin) sensitised and exposed Brown Norway
Externí odkaz:
https://doaj.org/article/2cf2cf37f88f49b7a32c81e104ae470f
Autor:
Erik van Tilburg Bernardes, Veronika Kuchařová Pettersen, Mackenzie W. Gutierrez, Isabelle Laforest-Lapointe, Nicholas G. Jendzjowsky, Jean-Baptiste Cavin, Fernando A. Vicentini, Catherine M. Keenan, Hena R. Ramay, Jumana Samara, Wallace K. MacNaughton, Richard J. A. Wilson, Margaret M. Kelly, Kathy D. McCoy, Keith A. Sharkey, Marie-Claire Arrieta
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The immunomodulatory role of commensal gut fungi and interactions with bacteria remain unclear. Here, using germ-free mice colonized with defined species of bacteria and fungi, the authors find that fungal colonization induces changes in bacterial mi
Externí odkaz:
https://doaj.org/article/7e7a71db7d15468095e5d2a5ace43434
Autor:
Taylor J. Bader, Jack K. Leacy, Joanna R. G. Keough, Anna‐Maria Ciorogariu‐Ivan, Joshua R. Donald, Anthony L. Marullo, Ken D. O’Halloran, Nicholas G. Jendzjowsky, Richard J. A. Wilson, Trevor A. Day
Publikováno v:
Physiological Reports, Vol 9, Iss 15, Pp n/a-n/a (2021)
Abstract The high metabolic demand of cerebral tissue requires that local perfusion is tightly coupled with local metabolic rate (neurovascular coupling; NVC). During chronic altitude exposure, where individuals are exposed to the antagonistic cerebr
Externí odkaz:
https://doaj.org/article/94c0bc6de4fb4a3c9d4d06c330971a7c
Autor:
Nicholas G. Jendzjowsky, Arijit Roy, Nicole O. Barioni, Margaret M. Kelly, Francis H. Y. Green, Christopher N. Wyatt, Richard L. Pye, Luana Tenorio-Lopes, Richard J. A. Wilson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Acute bronchoconstriction is the leading cause of asthmatic sudden death following allergen exposure. The authors show that the systemic increase of LPA following inhaled allergen or bradykinin challenge activates the carotid bodies through TRPV1 and
Externí odkaz:
https://doaj.org/article/7b65eae4fc874352ad6f95844a3997d9
Autor:
Nicholas G. Jendzjowsky, Craig D. Steinback, Robert J. Herman, Willis H. Tsai, Fiona E. Costello, Richard J. A. Wilson
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Sympathetic nervous system dysregulation and vascular impairment in neuronal tissue beds are hallmarks of prominent cardiorespiratory diseases. However, an accurate and convenient method of assessing SNA and local vascular regulation is lacking, hind
Externí odkaz:
https://doaj.org/article/de90a28f008a4b909220251d5ef58c1b
Autor:
Jordan D Bird, Scott A. Sands, Raichel M Alex, Conan L.H. Shing, Brooke M Shafer, Nicholas G Jendzjowsky, Richard J.A. Wilson, Trevor A Day, Glen E Foster
Publikováno v:
Annals of the American Thoracic Society.
Autor:
Sean van Diepen, Trevor A. Day, Nicholas G. Jendzjowsky, Britta R.M. Byman, Craig D. Steinback, Emily R. Vanden Berg, Scott F. Thrall, Lindsey F. Berthelsen, Andrew R. Steele, Richard J. A. Wilson, Jordan Bird, Alexandra Skalk, Brandon Pentz
Publikováno v:
European Journal of Applied Physiology. 122:475-487
PURPOSE Autonomic control of the heart is balanced by sympathetic and parasympathetic inputs. Excitation of both sympathetic and parasympathetic systems occurs concurrently during certain perturbations such as hypoxia, which stimulate carotid chemore
Autor:
Gurkarn Saran, Jordan Bird, Mingma T. Sherpa, Anne Kalker, Garrick Chan, Trevor A. Day, Thomas D. Brutsaert, Jason S. Chan, Alexander N. Rimke, Nicholas G. Jendzjowsky, Richard J. A. Wilson
Publikováno v:
Journal of Applied Physiology. 131:1432-1443
Central sleep apnea (CSA) is universal during ascent to high altitude, with intermittent and transient fluctuations in oxygen saturation, but the consequences on mean sleeping blood oxygenation are unclear. We assessed indices of CSA and mean sleepin
Autor:
Jacquie Baker, Mohammad A. Safarzadeh, Anthony V. Incognito, Nicholas G. Jendzjowsky, Glen E. Foster, Jordan D. Bird, Satish R. Raj, Trevor A. Day, Caroline A. Rickards, Natalia Zubieta-DeUrioste, Usman Alim, Richard J. A. Wilson
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 133(3)
Measuring the retinal microvasculature at high altitude provides a surrogate for cerebral microvasculature, offering potential insight into consequence of cerebral hypoxia in critical illness. This study demonstrates dynamic regulation of the retina
Autor:
Mircea Iftinca, Margaret M. Kelly, Nicholas G. Jendzjowsky, Nicole O. Barioni, Frank Visser, Christophe Altier, Arijit Roy, Richard J. A. Wilson, Brittney Herrington
Publikováno v:
The Journal of Physiology. 599:1335-1354
Key points We have previously shown that carotid body stimulation by lysophosphatidic acid elicits a reflex stimulation of vagal efferent activity sufficient to cause bronchoconstriction in asthmatic rats. Here, we show that pathophysiological concen