Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Nicholas Flavahan"'
Autor:
Jochen Steppan, Yehudit Bergman, Kayla Viegas, Dinani Armstrong, Siqi Tan, Huilei Wang, Sean Melucci, Daijiro Hori, Sung Yong Park, Sebastian F. Barreto, Abraham Isak, Sandeep Jandu, Nicholas Flavahan, Mark Butlin, Steven S. An, Alberto Avolio, Dan E. Berkowitz, Marc K. Halushka, Lakshmi Santhanam
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 2 (2017)
BackgroundThe structural elements of the vascular wall, namely, extracellular matrix and smooth muscle cells (SMCs), contribute to the overall stiffness of the vessel. In this study, we examined the crosslinking‐dependent and crosslinking‐indepen
Externí odkaz:
https://doaj.org/article/e77c31b413db422eadaac4b7e87402bf
Autor:
John C. McGrath, Nicholas Flavahan
Publikováno v:
British Journal of Pharmacology. 77:319-328
1 The chronotropic effects of alpha- and beta-adrenoceptor agonists were investigated in the pithed rat. 2 The beta-adrenoceptor agonist, isoprenaline, produced only a positive chronotropic response. alpha 1-Adrenoceptor agonists, phenylephrine and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee074f2b6aeea59b34b706dae3fbef5
https://doi.org/10.1111/j.1476-5381.1982.tb09301.x
https://doi.org/10.1111/j.1476-5381.1982.tb09301.x
Publikováno v:
Journal of Cardiovascular Pharmacology. 4:S101-S107
In pithed rats or rabbits the pressor effects of catecholamines or sympathetic nerve stimulation can be reduced by "selective" antagonists of alpha 1- (prazosin) or alpha 2 (rauwolscine) adrenoceptors. In rabbits the pressor response to low and high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12137605da9efc7dd9f6a31ab37ffaf9
https://doi.org/10.1097/00005344-198200041-00021
https://doi.org/10.1097/00005344-198200041-00021
Publikováno v:
Clinical Science. 68:99s-104s
1. The pressor responses in the pithed rat to α-adrenoceptor agonists can be modified by alterations in arterial blood gas levels or by drugs which interfere with excitation-contraction coupling processes in the vascular smooth muscle, e.g. Ca2+-ent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa2e89e22f829c4fe3a7876cf32fc19d
https://doi.org/10.1042/cs068s099
https://doi.org/10.1042/cs068s099
Publikováno v:
Clinical Science. 68:25s-30s
1. By the sequential administration of α1- and α2-blockers it can be shown, in the pithed rabbit, that the dose/pressor response curve to noradrenaline consists of two separate curves, one for each receptor. α2-mediated responses predominate at lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d272317617bcc0b9834383b4f70ab1f
https://doi.org/10.1042/cs068s025
https://doi.org/10.1042/cs068s025
Autor:
John C. McGrath, Nicholas Flavahan
Publikováno v:
British Journal of Pharmacology. 73:586-588
In the pithed rat, amidephrine a "selective" alpha 1-adrenoceptor agonist, evokes a positive chronotropic response. This response can be antagonized by prazosin but not by propranolol or by rauwolscine. Similarly, part of the chronotropic response to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca51c13a6b17b7c87256981eee802310
https://doi.org/10.1111/j.1476-5381.1981.tb16791.x
https://doi.org/10.1111/j.1476-5381.1981.tb16791.x
Autor:
Nicholas Flavahan, John C. McGrath
In the pithed rat, following beta-adrenoceptor blockade, the pressor effect of adrenaline can be blocked by phentolamine or by prazosin plus yohimbine but not by prazosin or yohimbine given alone. It is concluded that adrenaline produces its pressor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::210c4a0f48d6b438deb61fa9c9cca883
https://europepmc.org/articles/PMC2044272/
https://europepmc.org/articles/PMC2044272/
Publikováno v:
British journal of pharmacology. 91(3)
The subtypes of alpha-adrenoceptors which mediate pressor responses to sympathomimetic agonists or to nerve stimulation in pithed rabbits have been classified according to the effects of 'selective' antagonists and a comparison has been made, for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f9c22fdb1d022194839a0271a09533
https://pubmed.ncbi.nlm.nih.gov/2886172
https://pubmed.ncbi.nlm.nih.gov/2886172