Zobrazeno 1 - 10
of 484
pro vyhledávání: '"Nicholas F, Larusso"'
Autor:
Yashbir Singh, William A. Jons, John E. Eaton, Mette Vesterhus, Tom Karlsen, Ida Bjoerk, Andreas Abildgaard, Kristin Kaasen Jorgensen, Trine Folseraas, Derek Little, Aliya F. Gulamhusein, Kosta Petrovic, Anne Negard, Gian Marco Conte, Joseph D. Sobek, Jaidip Jagtap, Sudhakar K. Venkatesh, Gregory J. Gores, Nicholas F. LaRusso, Konstantinos N. Lazaridis, Bradley J. Erickson
Publikováno v:
European Radiology Experimental, Vol 6, Iss 1, Pp 1-9 (2022)
Abstract Background Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease that can lead to cirrhosis and hepatic decompensation. However, predicting future outcomes in patients with PSC is challenging. Our aim was to extract mag
Externí odkaz:
https://doaj.org/article/0fc4b5aca7cb421798ef5ee12f333942
Autor:
Jessica T. Hochberg, Aalam Sohal, Priya Handa, Bryan D. Maliken, Take-Kyun Kim, Kai Wang, Eric Gochanour, Yu Li, J. Bart Rose, James E. Nelson, Keith D. Lindor, Nicholas F. LaRusso, Kris V. Kowdley
Publikováno v:
JHEP Reports, Vol 5, Iss 6, Pp 100729- (2023)
Background & Aims: Primary sclerosing cholangitis (PSC) is a chronic, progressive cholestatic liver disease that can lead to end-stage liver disease and cholangiocarcinoma. High-dose ursodeoxycholic acid (hd-UDCA, 28–30 mg/kg/day) was evaluated in
Externí odkaz:
https://doaj.org/article/5f55f7c82ccc4e648d616781d4396537
Autor:
Douglas I. Walker, Brian D. Juran, Angela C. Cheung, Erik M. Schlicht, Yongliang Liang, Megan Niedzwiecki, Nicholas F. LaRusso, Gregory J. Gores, Dean P. Jones, Gary W. Miller, Konstantinos N. Lazaridis
Publikováno v:
Hepatology Communications, Vol 6, Iss 5, Pp 965-979 (2022)
Progress in development of prognostic and therapeutic options for the rare cholestatic liver diseases, primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC), is hampered by limited knowledge of their pathogeneses. In particular,
Externí odkaz:
https://doaj.org/article/71cdef31da544f249ec03b9bf014fede
Autor:
Nidhi Jalan‐Sakrikar, Thiago M. De Assuncao, Amaia Navarro‐Corcuera, Feda H. Hamdan, Lorena Loarca, Lindsey A. Kirkeby, Zachary T. Resch, Steven P. O’Hara, Brian D. Juran, Konstantinos N. Lazaridis, Charles B. Rosen, Julie K. Heimbach, Timucin Taner, Vijay H. Shah, Nicholas F. LaRusso, Robert C. Huebert
Publikováno v:
Hepatology Communications, Vol 6, Iss 2, Pp 345-360 (2022)
Primary sclerosing cholangitis (PSC) is a chronic fibroinflammatory disease of the biliary tract characterized by cellular senescence and periportal fibrogenesis. Specific disease features that are cell intrinsic and either genetically or epigenetica
Externí odkaz:
https://doaj.org/article/ca9f01c370f541249f03d813d0b08950
Autor:
John E. Eaton, Christopher L. Welle, Hannah Monahan, Ali Dean Tahboub Amawi, Ilkay Idilman, William S. Harmsen, Bogdan Dzyubak, Elizabeth W. Beiermann, Zeinab Bakhshi, Gregory J. Gores, Nicholas F. LaRusso, Andrea A. Gossard, Konstantinos N. Lazaridis, Sudhakar K. Venkatesh
Publikováno v:
Gastro Hep Advances, Vol 1, Iss 3, Pp 287-295 (2022)
Background and Aims: Several quantitative and qualitative magnetic resonance imaging (MRI) metrics have been reported to predict outcomes among those with primary sclerosing cholangitis (PSC). We aimed to compare the reproducibility and prognostic pe
Externí odkaz:
https://doaj.org/article/8f9fb90857d042b294dcf6ae083349a4
Autor:
William P. Martin, MBChB, MSc, Lisa E. Vaughan, MS, Kotaro Yoshida, MD, PhD, Naoki Takahashi, MD, Marie E. Edwards, BSE, Andrew Metzger, MS, Sarah R. Senum, BS, Tetyana V. Masyuk, PhD, Nicholas F. LaRusso, MD, Matthew D. Griffin, MBChB, DMed, Ziad El-Zoghby, MD, Peter C. Harris, PhD, Walter K. Kremers, PhD, David M. Nagorney, MD, Patrick S. Kamath, MD, Vicente E. Torres, MD, PhD, Marie C. Hogan, MD, PhD
Publikováno v:
Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 3, Iss 2, Pp 149-159 (2019)
Objective: To describe first episodes of bacterial cholangitis complicating autosomal dominant polycystic kidney disease (ADPKD) and autosomal dominant polycystic liver disease (ADPLD) and to identify risk factors for cholangitis episodes among patie
Externí odkaz:
https://doaj.org/article/4088a39c872b4493bd6a251e5cdc7eb7
Autor:
Mohammed Alsuraih, Steven P. O’Hara, Julie E. Woodrum, Nicholas E. Pirius, Nicholas F. LaRusso
Publikováno v:
JHEP Reports, Vol 3, Iss 3, Pp 100250- (2021)
Summary: Background & Aims: Cholangiocyte senescence is important in the pathogenesis of primary sclerosing cholangitis (PSC). We found that CDKN2A (p16), a cyclin-dependent kinase inhibitor and mediator of senescence, was increased in cholangiocytes
Externí odkaz:
https://doaj.org/article/cdce56d2b71b475c86cca17e5e0dc419
Autor:
Gerardo Calderon, Alison McRae, Juraj Rievaj, Judith Davis, Inuk Zandvakili, Sara Linker-Nord, Duane Burton, Geoffrey Roberts, Frank Reimann, Bronislava Gedulin, Adrian Vella, Nicholas F LaRusso, Michael Camilleri, Fiona M Gribble, Andres Acosta
Publikováno v:
EBioMedicine, Vol 55, Iss , Pp - (2020)
Background: The bile acid (BA) pathway plays a role in regulation of food intake and glucose metabolism, based mainly on findings in animal models. Our aim was to determine whether the BA pathway is altered and correctable in human obesity and diabet
Externí odkaz:
https://doaj.org/article/81f621a9ddf64e54b9db7c70d00bcc3d
Publikováno v:
Liver Research, Vol 2, Iss 4, Pp 200-208 (2018)
Hemobilia refers to bleeding from and/or into the biliary tract and is an uncommon but important cause of gastrointestinal hemorrhage. Reports of hemobilia date back to the 1600s, but due to its relative rarity and challenges in diagnosis, only in re
Externí odkaz:
https://doaj.org/article/41e962b1213d422e99c5c0c8aa90a97e
Autor:
Andria R. Robinson, Matthew J. Yousefzadeh, Tania A. Rozgaja, Jin Wang, Xuesen Li, Jeremy S. Tilstra, Chelsea H. Feldman, Siobhán Q. Gregg, Caroline H. Johnson, Erin M. Skoda, Marie-Céline Frantz, Harris Bell-Temin, Hannah Pope-Varsalona, Aditi U. Gurkar, Luigi A. Nasto, Renã A.S. Robinson, Heike Fuhrmann-Stroissnigg, Jolanta Czerwinska, Sara J. McGowan, Nadiezhda Cantu-Medellin, Jamie B. Harris, Salony Maniar, Mark A. Ross, Christy E. Trussoni, Nicholas F. LaRusso, Eugenia Cifuentes-Pagano, Patrick J. Pagano, Barbara Tudek, Nam V. Vo, Lora H. Rigatti, Patricia L. Opresko, Donna B. Stolz, Simon C. Watkins, Christin E. Burd, Claudette M. St. Croix, Gary Siuzdak, Nathan A. Yates, Paul D. Robbins, Yinsheng Wang, Peter Wipf, Eric E. Kelley, Laura J. Niedernhofer
Publikováno v:
Redox Biology, Vol 17, Iss , Pp 259-273 (2018)
Accumulation of senescent cells over time contributes to aging and age-related diseases. However, what drives senescence in vivo is not clear. Here we used a genetic approach to determine if spontaneous nuclear DNA damage is sufficient to initiate se
Externí odkaz:
https://doaj.org/article/d9a5a11c481f443f90c56186ddad5c93