Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nicholas F, Endres"'
Autor:
Ke Sherry Li, John G. Quinn, Matthew J. Saabye, Jesus F. Salcido Guerrero, Jim Nonomiya, Qihui Lian, Wilson Phung, Yevgeniy Izrayelit, Benjamin T. Walters, Amy Gustafson, Nicholas F. Endres, Maureen H. Beresini, Melinda M. Mulvihill
Publikováno v:
Analytical Chemistry. 94:1230-1239
Autor:
Ke Sherry, Li, John G, Quinn, Matthew J, Saabye, Jesus F Salcido, Guerrero, Jim, Nonomiya, Qihui, Lian, Wilson, Phung, Yevgeniy, Izrayelit, Benjamin T, Walters, Amy, Gustafson, Nicholas F, Endres, Maureen H, Beresini, Melinda M, Mulvihill
Publikováno v:
Analytical chemistry. 94(2)
With recent advances and success in several drugs designed to treat acute and chronic diseases, targeted covalent inhibitors show a resurgence in drug discovery. As covalent inhibition is time-dependent, the preferred quantitative potency metric of i
Autor:
Gail Lewis Phillips, Mark Merchant, Marc Hafner, Lori Friedman, Emily J. Hanan, Nicholas F. Endres, Emile Plise, Alan G. Olivero, Rebecca Hong, Michelle Nannini, Kyung Song, Steve Staben, Jane Guan, Shiva Malek, Anwesha Dey, Timothy P. Heffron, Donald S. Kirkpatrick, Kyle A. Edgar, Eric Stawiski, Laurent Salphati, Jason Oeh, Jeffrey Wallin, Jonathan Cheong, Stephen Schmidt, Deepak Sampath, Lilian Phu, William F. Forrest
Publikováno v:
Cancer Discov
PIK3CA is one of the most frequently mutated oncogenes; the p110a protein it encodes plays a central role in tumor cell proliferation. Small-molecule inhibitors targeting the PI3K p110a catalytic subunit have entered clinical trials, with early-phase
Autor:
Stephen Schmidt, Steve Sideris, Emily J. Hanan, Eric Torres, Jawahar Sudhamsu, Kyung Song, Lan K. Nguyen, Kyle A. Edgar, Nicholas F. Endres, Timothy J. Wendorff, Georgia Hatzivassiliou, Akash Das, Noriko Ishisoko, Lori Friedman, Victorai Schutz, Matt Saabye, Steven T. Staben, Hans E. Purkey, Divya Murali
Publikováno v:
Molecular Cancer Research. 18:PR03-PR03
Activating mutations in PIK3CA are among the most significant oncogenic events across all cancers, making it an important target for drug development. Yet the application of PI3K inhibitors in the clinic has been limited by the difficulty of achievin
Autor:
Jay T. Groves, John Kuriyan, Nicholas F. Endres, David E. Shaw, Erika Kovacs, Yibing Shan, Rahul Das, Yongjian Huang, Anton Arkhipov, Jeffrey G. Pelton, David E. Wemmer, Adam W. Smith
Publikováno v:
Endres, Nicholas F.; Das, Rahul; Smith, Adam W.; Arkhipov, Anton; Kovacs, Erika; Huang, Yongjian; et al.(2013). Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor. Cell, 152(3). Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/1dd3r9ck
Endres, Nicholas; Das, Rahul; Smith, Adam; Arkhipov, Anton; Kovacs, Erika; Huang, Yongjian; et al.(2013). Conformational Coupling Across the Plasma Membrane in Activation of the EGF receptor. Cell. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/6ds7b3j7
Endres, Nicholas; Das, Rahul; Smith, Adam; Arkhipov, Anton; Kovacs, Erika; Huang, Yongjian; et al.(2013). Conformational Coupling Across the Plasma Membrane in Activation of the EGF receptor. Cell. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/6ds7b3j7
SummaryHow the epidermal growth factor receptor (EGFR) activates is incompletely understood. The intracellular portion of the receptor is intrinsically active in solution, and to study its regulation, we measured autophosphorylation as a function of
Publikováno v:
The journal of physical chemistry. B. 120(5)
The spatial organization of lipid-anchored proteins in the plasma membrane directly influences cell signaling, but measuring such organization in situ is experimentally challenging. The canonical oncogene, c-Src, is a lipid anchored protein that play
Autor:
Thomas Schindler, Natalia Jura, John Kuriyan, Markus A. Seeliger, Nicholas F. Endres, Xuewu Zhang
Publikováno v:
Molecular Cell. 42:9-22
In contrast to the active conformations of protein kinases, which are essentially the same for all kinases, inactive kinase conformations are structurally diverse. Some inactive conformations are, however, observed repeatedly in different kinases, pe
Autor:
Nicholas F. Endres, Charles S. Craik, Deborah S. Dauber, Robert M. Stroud, K. Kinkead Reiling
Publikováno v:
Biochemistry. 41:4582-4594
The structure of HIV protease (HIV Pr) bound to JE-2147 (also named AG1776 or KNI-764) is determined here to 1.09 A resolution. This highest-resolution structure for HIV Pr allows refinement of anisotropic displacement parameters (ADPs) for all atoms
Publikováno v:
Trends in biochemical sciences. 39(10)
The activation of receptor tyrosine kinases in response to extracellular signals is a principal component of metazoan signaling. Structural analysis of the extracellular and intracellular domains of these receptors has shed substantial light on the m
Publikováno v:
Current opinion in structural biology. 21(6)
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase involved in cell growth that is often misregulated in cancer. Several recent studies highlight the unique structural mechanisms involved in its regulation. Some elucidate the i