Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nicholas E. Vangos"'
Autor:
Kun Ping Lu, Hyuk-Soo Seo, Yujin Chun, Christopher M. Browne, Theresa D. Manz, Xiao Zhen Zhou, Zainab M. Doctor, Xiaolan Lian, Zoe C. Yeoh, Shin Kibe, Scott B. Ficarro, Nir London, Benika J. Pinch, Nicholas E. Vangos, Behnam Nabet, Stephen Buratowski, Dina Daitchman, Shingo Kozono, Daniel Zaidman, Nathanael S. Gray, Jarrod A. Marto, Mikaela L. Mohardt, Li Tan, Sirano Dhe-Paganon, Ezekiel A. Geffken
Publikováno v:
Nature chemical biology
Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1) is commonly overexpressed in human cancers, including pancreatic ductal adenocarcinoma (PDAC). While Pin1 is dispensable for viability in mice, it is required for activated Ras to induce t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6565cbd6de180dcf92ba1d74b5e545e0
https://doi.org/10.1038/s41589-020-0550-9
https://doi.org/10.1038/s41589-020-0550-9
Autor:
Nicholas E. Vangos, Hyuk-Soo Seo, Takashi Mizutani, Tinghu Zhang, Kenneth C. Anderson, Nathanael S. Gray, Teru Hideshima, Sirano Dhe-Paganon
Immunomodulatory drugs (IMiDs) thalidomide, lenalidomide, and pomalidomide (Pom) bind to cereblon (CRBN) and trigger proteasomal degradation of neo-substrates IKZF1/3 leading to multiple myeloma (MM) cell apoptosis. Pomalidomide (Pom) also binds albe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85e9e895d6bc8df555305968acf8003f
https://doi.org/10.1101/2021.11.30.469594
https://doi.org/10.1101/2021.11.30.469594
Autor:
Evon Poon, Anli Yang, Xiao Zhou, Efrat Resnick, Daniel Zaidman, Roni Oren, Yann Jamin, Shingo Kozono, Colin J. Daniel, Ellen M. Langer, Shijie He, Behnam Nabet, Yu-Hong Chen, Christopher M. Browne, Hyuk-Soo Seo, Louis Chesler, Kun Ping Lu, Benika J. Pinch, Rosalie C. Sears, Shin Kibe, Liat Stoler-Barak, Ziv Shulman, Nir London, Samuel Sidi, Christian Dubiella, Thomas Look, Nicholas E. Vangos, Kazuhiro Koikawa, Xiaolan Lian, Chunhui Wang, Nathaniel Gray, Trevor Manz, Jarrod A. Marto, Richa B. Shah, Ezekiel A. Geffken, Sirano Dhe-Paganon, Scott B. Ficarro
The peptidyl-prolyl cis-trans isomerase, Pin1, acts as a unified signaling hub that is exploited in cancer to activate oncogenes and inactivate tumor suppressors, in particular through up-regulation of c-Myc target genes. However, despite considerabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3ceb5d0f3a7e590d161df59af1ffd9
https://doi.org/10.1101/2020.03.20.998443
https://doi.org/10.1101/2020.03.20.998443
Autor:
Sirano Dhe-Paganon, Benika J. Pinch, Mark W. Zimmerman, Richa B. Shah, Kun Ping Lu, Jarrod A. Marto, Shuning He, Eriko Koide, Daniel Zaidman, Christopher M. Browne, Ziv Shulman, Barbara Martins da Costa, Christian Dubiella, Evon Poon, Guillaume Adelmant, Nir London, Xiao Zhen Zhou, Chu Wang, Ellen M. Langer, Kazuhiro Koikawa, Theresa D. Manz, Thomas Look, Xiaolan Lian, Hyuk-Soo Seo, Annan Yang, Louis Chesler, Ezekiel A. Geffken, Liat Stoler-Barak, Shin Kibe, Efrat Resnick, Nicholas E. Vangos, Shabnam Sharifzadeh, Shingo Kozono, Colin J. Daniel, Scott B. Ficarro, Roni Oren, Ying Chen, Nathanael S. Gray, Rosalie C. Sears, Samuel Sidi, Adi Rogel, Zainab M. Doctor, Behnam Nabet, Yann Jamin
Publikováno v:
Nat Chem Biol
The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors. However, despite considerable efforts, Pin1 has remained an elusive drug target. Here, we screened an electrophilic fragment library t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8338cdca0db7efbd0dc3ed699641997f
https://pubmed.ncbi.nlm.nih.gov/34040180
https://pubmed.ncbi.nlm.nih.gov/34040180
Autor:
Lynda M. Rose, Yusuke Fukuda, Rosalind A. Segal, Ozge E. Tasdemir-Yilmaz, Jarrod A. Marto, Li Y, Sirano Dhe-Paganon, Bird Gh, Maria F. Pazyra-Murphy, Nicholas E. Vangos, Loren D. Walensky, Hyuk-Soo Seo, Ezekiel A. Geffken, Guillaume Adelmant, Zoe C. Yeoh
Complex neural circuitry requires stable connections formed by lengthy axons. To maintain these functional circuits, fast transport delivers RNAs to distal axons where they undergo local translation. However, the mechanism that enables long distance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0c242c1ade50e2001e47a416fa1d59
Autor:
Roodolph St. Pierre, Lee Barrett, Clifford J. Woolf, Tom W. Muir, Hai T. Dao, Alfredo M. Valencia, Olubusayo Bolonduro, Zoe C. Yeoh, Clayton K. Collings, Crystal Hermawan, Cigall Kadoch, Yung-Chih Cheng, Zhen-Yu Sun, Mary K. Dornon, Nicholas E. Vangos, Dawn E. Comstock, Hyuk-Soo Seo, Sirano Dhe-Paganon, Nazar Mashtalir, Junwei Huang
Publikováno v:
Cell
Summary Mammalian switch/sucrose non-fermentable (mSWI/SNF) complexes are multi-component machines that remodel chromatin architecture. Dissection of the subunit- and domain-specific contributions to complex activities is needed to advance mechanisti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e62d2ea085e0e4c21a072c2e7881d8
https://pubmed.ncbi.nlm.nih.gov/31759698
https://pubmed.ncbi.nlm.nih.gov/31759698
Autor:
Reza Abdi, Leonard D. Shultz, Xiaolong Zhang, Dale L. Greiner, Jing Zhao, Yi-Jun Wang, Takaharu Ichimura, Ian Curtin, Zhen-Yu Jim Sun, Vivek Kasinath, Zoe C. Yeoh, Xiaofei Li, Qingming Hou, Naima Banouni, Gregory J. Heffron, Mayuko Uehara, Nicholas E. Vangos, Ezekiel A. Geffken, Liwei Jiang, Ze-Xian Liu, Li Dai, Sirano Dhe-Paganon, Hyuk-Soo Seo, Khalid Shah
Publikováno v:
Cell
Cancer therapies kill tumors either directly or indirectly by evoking immune responses and have been combined with varying levels of success. Here, we describe a paradigm to control cancer growth that is based on both direct tumor killing and the tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78acc246c0903739d13ccde7fc8f6f32
https://doi.org/10.1016/j.cell.2020.10.045
https://doi.org/10.1016/j.cell.2020.10.045