Výsledky vyhledávání - "Nicholas E Powers"

Akademický článek

Langerhans cells and cDC1s play redundant roles in mRNA-LNP induced protective anti-influenza and anti-SARS-CoV-2 immune responses.

Autor: Sonia Ndeupen, Aurélie Bouteau, Christopher Herbst, Zhen Qin, Sonya Jacobsen, Nicholas E Powers, Zachary Hutchins, Drishya Kurup, Leila Zabihi Diba, Megan Watson, Holly Ramage, Botond Z Igyártó

Publikováno v: PLoS Pathogens, Vol 18, Iss 1, p e1010255 (2022)

Nucleoside modified mRNA combined with Acuitas Therapeutics' lipid nanoparticles (LNPs) has been shown to support robust humoral immune responses in many preclinical animal vaccine studies and later in humans with the SARS-CoV-2 vaccination. We recen

Externí odkaz: https://doaj.org/article/f8eb0e3078144ef88f3868bb3e7f5caa

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Dexamethasone and OLT1177 Cooperate in the Reduction of Melanoma Growth by Inhibiting STAT3 Functions

Autor: Alberto Dinarello, Taylor S. Mills, Isak W. Tengesdal, Nicholas E. Powers, Tania Azam, Charles A. Dinarello

Publikováno v: Cells, Vol 12, Iss 2, p 294 (2023)

The NLRP3 inflammasome is a multimolecular complex that processes inactive IL-1β and IL-18 into proinflammatory cytokines. OLT1177 is an orally active small compound that specifically inhibits NLRP3. Here, B16F10 melanoma were implanted in mice and

Externí odkaz: https://doaj.org/article/abd15eeebeaa438fbc479ff0c62ae5a3

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Metabolic Reprogramming of Mouse Bone Marrow Derived Macrophages Following Erythrophagocytosis

Autor: Alexis Catala, Lyla A. Youssef, Julie A. Reisz, Monika Dzieciatkowska, Nicholas E. Powers, Carlo Marchetti, Matthew Karafin, James C. Zimring, Krystalyn E. Hudson, Kirk C. Hansen, Steven L. Spitalnik, Angelo D’Alessandro

Publikováno v: Frontiers in Physiology, Vol 11 (2020)

Reticuloendothelial macrophages engulf ∼0.2 trillion senescent erythrocytes daily in a process called erythrophagocytosis (EP). This critical mechanism preserves systemic heme-iron homeostasis by regulating red blood cell (RBC) catabolism and iron

Externí odkaz: https://doaj.org/article/8ab447cfcb524cb6a70f041c83dc87ca

Zobrazit plný text záznamu

Activation of Host-NLRP3 Inflammasome in Myeloid Cells Dictates Response to Anti-PD-1 Therapy in Metastatic Breast Cancers

Autor: Isak W. Tengesdal, Suzhao Li, Nicholas E. Powers, Makenna May, Charles P. Neff, Leo A. B. Joosten, Carlo Marchetti, Charles A. Dinarello

Publikováno v: Pharmaceuticals; Volume 15; Issue 5; Pages: 574
Pharmaceuticals, 15
Pharmaceuticals, 15, 5

Tumor-associated inflammation leads to dysregulated cytokine production that promotes tumor immune evasion and anti-tumor immunity dysfunction. In advanced stage breast cancer, the proinflammatory cytokine IL-1β is overexpressed due to large proport

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1832824ec2e14aa68742b0a9a30f67c

Zobrazit plný text záznamu

Plný text ve formátu HTML

PASylation of IL-1 receptor antagonist (IL-1Ra) retains IL-1 blockade and extends its duration in mouse urate crystal-induced peritonitis

Autor: Rajiv Datar, Carlo Marchetti, Benjamin J Swartzwelter, Charles A. Dinarello, Carl K. Edwards, Uli Binder, Martin Schlapschy, Arne Skerra, Dennis M. de Graaf, Nicholas E. Powers, Alexandra Lerchner

Publikováno v: J Biol Chem
Journal of Biological Chemistry, 295, 3, pp. 868-882
Journal of Biological Chemistry, 295, 868-882

Interleukin-1 (IL-1) is a key mediator of inflammation and immunity. Naturally-occurring IL-1 receptor antagonist (IL-1Ra) binds and blocks the IL-1 receptor-1 (IL-1R1), preventing signaling. Anakinra, a recombinant form of IL-1Ra, is used to treat a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4c17b1368a9c115cafec49dfdb8696
https://doi.org/10.1016/s0021-9258(17)49941-8

Zobrazit plný text záznamu

Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences USA, 118
Proceedings of the National Academy of Sciences USA, 118, 10

Significance The nucleotide-binding domain, leucine-rich containing family, pyrin domain-containing-3 (NLRP3) inflammasome, an intracellular complex that regulates maturation and release of interleukin (IL)-1β, is active in biopsies of metastatic me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ce371aacf6f09b53e1fd04dd31ce69
https://doi.org/10.1073/pnas.2000915118

Zobrazit plný text záznamu

Tumor NLRP3-Derived IL-1β Drives the IL-6/STAT3 Axis Resulting in Sustained MDSC-Mediated Immunosuppression

Autor: Nicholas E. Powers, Leo A. B. Joosten, Alberto Dinarello, Charles A. Dinarello, Matthew A. Burchill, Carlo Marchetti, Isak W. Tengesdal

Publikováno v: Frontiers in Immunology, 12
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)

Tumors evade the immune system by inducing inflammation. In melanoma, tumor-derived IL-1β drives inflammation and the expansion of highly immunosuppressive myeloid-derived suppressor cells (MDSCs). Similar in many tumors, melanoma is also linked to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0390ff6df398520fde552db4a1350928
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/238104

Zobrazit plný text záznamu

Human recombinant interleukin-38 suppresses inflammation in mouse models of local and systemic disease

Autor: Frank L. van de Veerdonk, Nicholas E. Powers, Dennis M. de Graaf, Leo A. B. Joosten, Sanne P. Smeekens, Mark S. Gresnigt, Jasmina S. Redzic, Suzhao Li, Monique M. Helsen, Charles A. Dinarello, Ralph J.A. Maas, Vassili Kalabokis, Elan Z. Eisenmesser

Publikováno v: Cytokine, 137
Cytokine

Interleukin (IL)–38 belongs to the IL–1 family and is part of the IL–36 subfamily due to its binding to the IL–36 Receptor (IL–1R6). In the current study, we assessed the anti-inflammatory properties of IL–38 in murine models of arthritis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007616c3af4e553855e35b5df156f4b2
https://hdl.handle.net/2066/228538

Zobrazit plný text záznamu

A novel anti-human IL-1R7 antibody reduces IL-18-mediated inflammatory signaling

Autor: Jared J. Lindenberger, Nicholas E. Powers, Karsten Beckmann, Liqiong Jiang, Suzhao Li, Stephan Fischer, Dennis M. de Graaf, Ulrich Pessara, Charles A. Dinarello, Jesper F Højen, Elan Z. Eisenmesser, Tania Azam

Publikováno v: Li, S, Jiang, L, Beckmann, K, Højen, J F, Pessara, U, Powers, N E, de Graaf, D M, Azam, T, Lindenberger, J, Eisenmesser, E Z, Fischer, S & Dinarello, C A 2021, ' A novel anti-human IL-1R7 antibody reduces IL-18-mediated inflammatory signaling ', The Journal of Biological Chemistry, vol. 296, 100630 . https://doi.org/10.1016/J.JBC.2021.100630
The Journal of Biological Chemistry

Unchecked inflammation can result in severe diseases with high mortality, such as macrophage activation syndrome (MAS). MAS and associated cytokine storms have been observed in COVID-19 patients exhibiting systemic hyper-inflammation. Interleukin-18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::851f20ff30c87257bb17818022c0f22a
https://doi.org/10.1016/j.jbc.2021.100630

Zobrazit plný text záznamu

Measuring The Impact Of The Toxics Release Inventory: Evidence From Manufacturing Plant Births

Autor: Nicholas E. Powers

The Toxics Release Inventory was the first major initiative to take a disclosurebased approach to environmental regulation and has served as the model for several other disclosure-based environmental policies. Yet the magnitude of its direct impacts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______645::b2139777db81cd1505d2acfdb8f008b8
https://www2.census.gov/ces/wp/2013/CES-WP-13-07.pdf

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání