Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Nicholas E, Shepherd"'
Autor:
Jason K.K. Low, Ana P.G. Silva, Mehdi Sharifi Tabar, Mario Torrado, Sarah R. Webb, Benjamin L. Parker, Maryam Sana, Callum Smits, Jason W. Schmidberger, Lou Brillault, Matthew J. Jackman, David C. Williams, Jr., Gerd A. Blobel, Sandra B. Hake, Nicholas E. Shepherd, Michael J. Landsberg, Joel P. Mackay
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108450- (2020)
Summary: The nucleosome remodeling and deacetylase (NuRD) complex is essential for metazoan development but has been refractory to biochemical analysis. We present an integrated analysis of the native mammalian NuRD complex, combining quantitative ma
Externí odkaz:
https://doaj.org/article/67462e4b5dec48dc92db0b2bce9d1594
Autor:
Timothy A. Hill, David P. Fairlie, Gloria Ruiz-Gómez, Frederik Diness, Nicholas E. Shepherd, Giovanni Abbenante, Huy N. Hoang, Jody M. Mason, Chongyang Wu
Publikováno v:
Chemical Science. 10:10595-10600
Protein–protein interactions involve hotspots as small as 4 sequential amino acids. Corresponding tetrapeptides have no structure in water. Here we report linking side chains of amino acids X and Z to form 24 cyclic tetrapeptides, cyclo-[XAAZ]-NH2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::398f2aed8914bac6e458761394ec1d60
https://doi.org/10.1039/c9sc04153b
https://doi.org/10.1039/c9sc04153b
Autor:
Molly K Clifton, Belinda J Westman, Sock Yue Thong, Mitchell R O'Connell, Michael W Webster, Nicholas E Shepherd, Kate G Quinlan, Merlin Crossley, Gerd A Blobel, Joel P Mackay
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e106011 (2014)
FOG1 is a transcriptional regulator that acts in concert with the hematopoietic master regulator GATA1 to coordinate the differentiation of platelets and erythrocytes. Despite considerable effort, however, the mechanisms through which FOG1 regulates
Externí odkaz:
https://doaj.org/article/6dfd3650942b47ce96da391ba8c4dabf
Autor:
Huy N, Hoang, Timothy A, Hill, Gloria, Ruiz-Gómez, Frederik, Diness, Jody M, Mason, Chongyang, Wu, Giovanni, Abbenante, Nicholas E, Shepherd, David P, Fairlie
Publikováno v:
Chemical Science
Twisting or turning peptides: ring size and chi angle in side chain cross-linked tetrapeptides together control α- or β-turn structures, which mimic irregular secondary structures in proteins.
Protein–protein interactions involve hotspots as
Protein–protein interactions involve hotspots as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::73b0aabd2e8bf285803ee698344cebea
https://pubmed.ncbi.nlm.nih.gov/32110345
https://pubmed.ncbi.nlm.nih.gov/32110345
Autor:
Hinnerk Saathoff, Benjamin L. Parker, Nicholas E. Shepherd, Mario Torrado, Ana P. G. Silva, Daniel P. Ryan, Mattias Brofelth, Jason Low, Sarah R. Webb, Joel P. Mackay
Publikováno v:
Journal of Biological Chemistry. 291:15853-15866
Chromatin remodeling enzymes act to dynamically regulate gene accessibility. In many cases, these enzymes function as large multicomponent complexes that in general comprise a central ATP-dependent Snf2 family helicase that is decorated with a variab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab584ec1261927bf0daff0e337bccf6
https://doi.org/10.1074/jbc.m115.707018
https://doi.org/10.1074/jbc.m115.707018
Autor:
Timothy A. Hill, Renee L. Beyer, David P. Fairlie, Fabien Plisson, Lena Goedecke, Nicholas E. Shepherd, Rosemary S. Harrison, Aline Dantas de Araujo, Russell W. Driver, Huy N. Hoang
Publikováno v:
Angewandte Chemie. 128:8415-8419
Cyclic pentapeptides (e.g. Ac-(cyclo-1,5)-[KAXAD]-NH2; X = Ala, 1; Arg, 2) in water adopt one alpha-helical turn defined by three hydrogen bonds. NMR structure analysis reveals a slight distortion from alpha-helicity at the C-terminal aspartate cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a8311ba28f5bdaa169a8ea4f3cd394
https://doi.org/10.1002/ange.201602079
https://doi.org/10.1002/ange.201602079
Autor:
Maryam Sana, Mehdi Sharifi Tabar, Michael J. Landsberg, Jason W. Schmidberger, Callum Smits, Joel P. Mackay, Sarah R. Webb, Benjamin L. Parker, Matthew J Jackman, Ana P. G. Silva, Lou Brillault, Gerd A. Blobel, Nicholas E. Shepherd, Mario Torrado, Jason Low, David C. Williams, Sandra B. Hake
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108450-(2020)
The Nucleosome Remodeling and Deacetylase (NuRD) complex is essential for development in complex animals but has been refractory to biochemical analysis. We present the first integrated analysis of the architecture of the native mammalian NuRD comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c315a53a100695da297d5f427641346c
https://doi.org/10.1016/j.celrep.2020.108450
https://doi.org/10.1016/j.celrep.2020.108450
Autor:
Giovanni Abbenante, Frederik Diness, Timothy A. Hill, Jody M. Mason, Huy N. Hoang, Gloria Ruiz-Gómez, Nicholas E. Shepherd, Chongyang Wu, David P. Fairlie
Publikováno v:
Chemical Science. 11:7511-7511
Correction for ‘Twists or turns: stabilising alpha vs. beta turns in tetrapeptides’ by Huy N. Hoang et al., Chem. Sci., 2019, 10, 10595–10600, DOI: 10.1039/C9SC04153B.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eced2ff5243fda1e593123a00eb74378
https://doi.org/10.1039/d0sc90138e
https://doi.org/10.1039/d0sc90138e
Autor:
Joel P. Mackay, Daniel P. Ryan, Benjamin L. Parker, Hinnerk Saathoff, Jason Low, Mattias Brofelth, Nicholas E. Shepherd, Ana P. G. Silva, Anne Trinh, Sarah R. Webb
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:960-965
We have developed an approach for directly isolating an intact multi-protein chromatin remodeling complex from mammalian cell extracts using synthetic peptide affinity reagent 4. FOG1(1–15), a short peptide sequence known to target subunits of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da19195863126c1274c09010a27984de
https://doi.org/10.1016/j.bmc.2015.01.023
https://doi.org/10.1016/j.bmc.2015.01.023
Publikováno v:
Tetrahedron. 71:813-819
Nitroxide labels are useful probes of biomolecule structure that can be detected by NMR and EPR spectroscopy. Although many methods exist for labeling oligonucleotides with nitroxides, most require reagents that are expensive or laborious to prepare.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70799da10a21e463e83f728de26211a1
https://doi.org/10.1016/j.tet.2014.12.056
https://doi.org/10.1016/j.tet.2014.12.056