Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Nicholas E, Baker"'
Autor:
Sudershana Nair, Nicholas E Baker
Publikováno v:
eLife, Vol 12 (2024)
Many cell fate decisions are determined transcriptionally. Accordingly, some fate specification is prevented by Inhibitor of DNA-binding (Id) proteins that interfere with DNA binding by master regulatory transcription factors. We show that the Drosop
Externí odkaz:
https://doaj.org/article/9ac920143de8498a85c89794e8b48706
Publikováno v:
Biology Open, Vol 13, Iss 8 (2024)
Externí odkaz:
https://doaj.org/article/6204342919dc4672a5de598dec3a0898
Autor:
Marianthi Kiparaki, Nicholas E. Baker
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102653- (2023)
Summary: Translation is a fundamental process of cellular behavior. Here, we present a protocol for measuring translation in Drosophila epithelial tissues using O-propargyl-puromycin (OPP), a puromycin derivative. We detail steps for larval dissectio
Externí odkaz:
https://doaj.org/article/d9b70a07545941f3b251d7ab38c56803
Publikováno v:
eLife, Vol 12 (2023)
Ribosomal protein (Rp) gene haploinsufficiency can result in Diamond-Blackfan Anemia (DBA), characterized by defective erythropoiesis and skeletal defects. Some mouse Rp mutations recapitulate DBA phenotypes, although others lack erythropoietic or sk
Externí odkaz:
https://doaj.org/article/014e9d7011b54d02990debfef26a3675
Autor:
Nicholas E. Baker, Cristina Montagna
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 11 (2022)
Externí odkaz:
https://doaj.org/article/7ef5234922d441bcb02a6415aff6163d
Autor:
Marianthi Kiparaki, Chaitali Khan, Virginia Folgado-Marco, Jacky Chuen, Panagiotis Moulos, Nicholas E Baker
Publikováno v:
eLife, Vol 11 (2022)
Ribosomal Protein (Rp) gene haploinsufficiency affects translation rate, can lead to protein aggregation, and causes cell elimination by competition with wild type cells in mosaic tissues. We find that the modest changes in ribosomal subunit levels o
Externí odkaz:
https://doaj.org/article/a9adcb8fd2294cfcaa650d9525294658
Publikováno v:
eLife, Vol 9 (2020)
Reduced copy number of ribosomal protein (Rp) genes adversely affects both flies and mammals. Xrp1 encodes a reportedly Drosophila-specific AT-hook, bZIP protein responsible for many of the effects including the elimination of Rp mutant cells by comp
Externí odkaz:
https://doaj.org/article/c4745a76f5704d358dd790f1b3f2d3e9
Autor:
Zhejun Ji, Marianthi Kiparaki, Virginia Folgado, Amit Kumar, Jorge Blanco, Gerard Rimesso, Jacky Chuen, Yang Liu, Deyou Zheng, Nicholas E Baker
Publikováno v:
PLoS Genetics, Vol 15, Iss 12, p e1008513 (2019)
Whereas complete loss of Rp function is generally lethal, most heterozygous Rp mutants grow more slowly and are subject to competitive loss from mosaics tissues that also contain wild type cells. The rpS12 gene has a special role in the cell competit
Externí odkaz:
https://doaj.org/article/9f20339a45b04c3d80e3e3d46ab1a888
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 10, Pp 3207-3217 (2016)
Cell competition, the conditional loss of viable genotypes only when surrounded by other cells, is a phenomenon observed in certain genetic mosaic conditions. We conducted a chemical mutagenesis and screen to recover new mutations that affect cell co
Externí odkaz:
https://doaj.org/article/94490ce55eb141edb8ae4a7b041fdb7f
Autor:
Abhijit Kale, Nicholas E. Baker
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 5 (2018)
Tumor cells often differ genetically from normal cells and from one another. Competitive interactions can occur between genetically-distinct cells, and recent studies highlight multiple examples where cell competition initiates using distinct pathway
Externí odkaz:
https://doaj.org/article/8e174f8939b8407d86376d39778269cc