Restoration of atypical protein kinase C ζ function in autosomal dominant polycystic kidney disease ameliorates disease progression

Autor: Masaw Akbari, Jonathan D. West, Nicholas Doerr, Kevin R. Kipp, Neda Marhamati, Sabrina Vuong, Yidi Wang, Markus M. Rinschen, Jeffrey J. Talbot, Oliver Wessely, Thomas Weimbs

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 30
Akbari, M, West, J D, Doerr, N, Kipp, K R, Marhamati, N, Vuong, S, Wang, Y, Rinschen, M M, Talbot, J J, Wessely, O & Weimbs, T 2022, ' Restoration of atypical protein kinase C ζ function in autosomal dominant polycystic kidney disease ameliorates disease progression ', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 30, e2121267119 . https://doi.org/10.1073/pnas.2121267119

Autosomal dominant polycystic kidney disease (ADPKD) affects more than 500,000 individuals in the United States alone. In most cases, ADPKD is caused by a loss-of-function mutation in the PKD1 gene, which encodes polycystin-1 (PC1). Previous studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f72725d05c6f86d382499b53f3482e3
https://escholarship.org/uc/item/0rw4q0ck

Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA

Autor: Nicholas Doerr, Florian Bernet, Thomas Weimbs, Justyna Iwaszkiewicz, Séverine Urfer, Lucia Carolina Leal-Esteban, Daniel B. Constam, Benjamin Rothé

Publikováno v: Molecular and Cellular Biology
Molecular and cellular biology, vol 35, iss 19

Loss of the RNA-binding protein Bicaudal-C (Bicc1) provokes renal and pancreatic cysts as well as ectopic Wnt/beta-catenin signaling during visceral left-right patterning. Renal cysts are linked to defective silencing of Bicc1 target mRNAs, including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea9fb43db9093549bc982d01a6333dc0
http://mcb.asm.org/content/35/19/3339.long

Regulation of Polycystin-1 Function by Calmodulin Binding

Autor: Guangyi Liu, Maki Takahashi, Jesse J. Benza, Ashraf M. Mohieldin, Surya M. Nauli, Kevin R. Kipp, Tengis S. Pavlov, Nicholas Doerr, Thomas Weimbs, Vladimir Z. Pletnev, Yidi Wang, Alexander Staruschenko

Publikováno v: PloS one, vol 11, iss 8
PLoS ONE
PLoS ONE, Vol 11, Iss 8, p e0161525 (2016)

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common genetic disease that leads to progressive renal cyst growth and loss of renal function, and is caused by mutations in the genes encoding polycystin-1 (PC1) and polycystin-2 (PC2), respe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c3ba13798c5599980be5f04b0d3c0de
https://escholarship.org/uc/item/7pn0w1cg

Design, Synthesis, and Evaluation of Orally Active Benzimidazoles and Benzoxazoles as Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase Inhibitors

Autor: Anthony Polverino, Yan Gu, Roger Zanon, Lucian DiPietro, Joseph L. Kim, Michele Potashman, Paul E. Rose, Juan Estrada, Thomas DeMelfi, Paul Gallant, Rick Kendall, Angela Coxon, Douglas A. Whittington, Stephen Kaufman, Alexander M. Long, Nicholas Doerr, Huilin Zhao, Gondi N. Kumar, Simon Van Der Plas, Julie Germain, Daniel Elbaum, Jean-Christophe Harmange, Vinod F. Patel, Seshadri Neervannan, James Bready

Publikováno v: Journal of Medicinal Chemistry. 50:4351-4373

Inhibition of the VEGF signaling pathway has become a valuable approach in the treatment of cancers. Guided by X-ray crystallography and molecular modeling, a series of 2-aminobenzimidazoles and 2-aminobenzoxazoles were identified as potent inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546ab5d4d65a000343627ca1556a94c5
https://doi.org/10.1021/jm070034i

Repair of local bone erosions and reversal of systemic bone loss upon therapy with anti-tumor necrosis factor in combination with osteoprotegerin or parathyroid hormone in tumor necrosis factor-mediated arthritis

Autor: Kurt Redlich, George Kollias, Helga Bergmeister, Günter Steiner, Paul J. Kostenuik, Silvia Hayer, Nicholas Doerr, Georg Schett, Jochen Zwerina, Josef S. Smolen, Birgit Görtz

Publikováno v: The American journal of pathology. 164(2)

Local bone erosion and systemic bone loss are hallmarks of rheumatoid arthritis and cause progressive disability. Tumor necrosis factor (TNF) is a key mediator of arthritis and acts catabolically on bone by stimulating bone resorption and inhibiting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27fe70b06646ae13ffb6f227a8d5ede2
https://pubmed.ncbi.nlm.nih.gov/14742260