Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nicholas Denomme"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-21 (2023)
Abstract Voltage gated sodium channels (VGSCs) are required for action potential initiation and propagation in mammalian neurons. As with other ion channel families, VGSC density varies between neurons. Importantly, sodium current (I Na ) density var
Externí odkaz:
https://doaj.org/article/0bcb2363d1794048ae424adcff6473c4
Autor:
Jacob M. Hull, Heather A. O’Malley, Chunling Chen, Yukun Yuan, Nicholas Denomme, Alexandra A. Bouza, Charles Anumonwo, Luis F. Lopez‐Santiago, Lori L. Isom
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 11, Pp 2137-2149 (2020)
Abstract Objective Human variants in voltage‐gated sodium channel (VGSC) α and β subunit genes are linked to developmental and epileptic encephalopathies (DEEs). Inherited, biallelic, loss‐of‐function variants in SCN1B, encoding the β1/β1B
Externí odkaz:
https://doaj.org/article/34e03d65f7274edcbd5c7e0136263957
Autor:
Chunling Chen, Charles Anumonwo, Heather A. O'Malley, Alexandra A. Bouza, Yukun Yuan, Jacob M. Hull, Luis F. Lopez-Santiago, Nicholas Denomme, Lori L. Isom
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 11, Pp 2137-2149 (2020)
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology
Objective Human variants in voltage‐gated sodium channel (VGSC) α and β subunit genes are linked to developmental and epileptic encephalopathies (DEEs). Inherited, biallelic, loss‐of‐function variants in SCN1B, encoding the β1/β1B subunits,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c85a4560c7402f274037730b5d5926
https://doaj.org/article/34e03d65f7274edcbd5c7e0136263957
https://doaj.org/article/34e03d65f7274edcbd5c7e0136263957
Publikováno v:
Pharmacological Reviews. 71:450-466
Despite continuous clinical use for more than 170 years, the mechanism of general anesthetics has not been completely characterized. In this review, we focus on the role of voltage-gated sodium channels in the sedative-hypnotic actions of halogenated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe1bfda9db8f025e8d0a8ee8e8813cd
https://doi.org/10.1124/pr.118.016592
https://doi.org/10.1124/pr.118.016592
Autor:
April L. Lukowski, Sherwood Hall, Lori L. Isom, Alison R. H. Narayan, Meagan E. Hinze, Nicholas Denomme
Publikováno v:
ACS chemical biology. 14(5)
[Image: see text] Small molecules that bind to voltage-gated sodium channels (VGSCs) are promising leads in the treatment of numerous neurodegenerative diseases and pain. Nature is a highly skilled medicinal chemist in this regard, designing potent V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205af5aea67cf9595ad9f8b3d1b4e5fc
https://pubmed.ncbi.nlm.nih.gov/30983320
https://pubmed.ncbi.nlm.nih.gov/30983320
Autor:
Alexandra A. Bouza, Nicholas Denomme, Jacob M. Hull, April L. Lukowski, Margaret B. Jameson, Lori L. Isom, Alison R. H. Narayan
Publikováno v:
Neurosci Lett
Voltage-gated sodium channels (VGSCs) are responsible for the initiation and propagation of action potentials in neurons. The human genome includes ten human VGSC α-subunit genes, SCN(X)A, encoding Na(v)1.1–1.9 plus Na(x). To understand the unique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a79618fd544b99ec0edcc5c531f175
https://doi.org/10.1016/j.neulet.2020.134853
https://doi.org/10.1016/j.neulet.2020.134853
Autor:
B S Nicholas Denomme
Publikováno v:
Journal of psychoactive drugs. 50(4)
University of Michigan Pharmacology Professor Ed Domino is an expert in the field of neuropsychopharmacology. For over six decades, Dr. Domino has made many contributions to our understanding of psychoactive drugs, but is most well-known for his role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae60360715e6057beace341affd9f60a
https://pubmed.ncbi.nlm.nih.gov/30111247
https://pubmed.ncbi.nlm.nih.gov/30111247