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Autor:
Samantha E. Cooper, Jillian E. Smith-Carpenter, Lazaros Stefanidis, Nicholas D. Fusco, Benjamin J. Alper
Publikováno v:
Biochemistry. 57(32)
Insulin-degrading enzyme (IDE) is a 110 kDa chambered zinc metalloendopeptidase that degrades insulin, amyloid β, and other intermediate-sized aggregation prone peptides that adopt β-structures. Structural studies of IDE in complex with multiple ph