Malaria: Targeting parasite and host cell kinomes

Autor: Christian Doerig, Clare Fennell, Luc Reininger, Audrey Sicard, Abdirahman I. Abdi, Jean Philippe Semblat, Zoe Holland, Marie-Paule Nivez, Dominique Dorin-Semblat, Jean Halbert, Nicholas D. Bland, Sylvain C.P. Eschenlauer

Publikováno v: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1804:604-612

Malaria still remains one of the deadliest infectious diseases, and has a tremendous morbidity and mortality impact in the developing world. The propensity of the parasites to develop drug resistance, and the relative reluctance of the pharmaceutical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc01f455cc236a40e8184b520055ebc2
https://doi.org/10.1016/j.bbapap.2009.10.009

Structures of Leishmania major orthologues of macrophage migration inhibitory factor

Autor: Sandra A. Bruce, Malcolm D. Walkinshaw, Julia M. Richardson, Nicholas D. Bland, Graham H. Coombs, Lesley S. Morrison, Jeremy C. Mottram

Publikováno v: Richardson, J M, Morrison, L S, Bland, N D, Bruce, S, Coombs, G H, Mottram, J C & Walkinshaw, M D 2009, ' Structures of Leishmania major orthologues of macrophage migration inhibitory factor ', Biochemical and Biophysical Research Communications, vol. 380, no. 3, pp. 442-8 . https://doi.org/10.1016/j.bbrc.2009.01.030

Leishmania major, an intracellular parasitic protozoon that infects, differentiates and replicates within macrophages, expresses two closely related MIF-like proteins. To ascertain the roles and potential differences of these two Leishmania proteins,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c6b08dc07041cdc91959ce99808be3
https://doi.org/10.1016/j.bbrc.2009.01.030

Drosophila melanogaster NEP2 is a new soluble member of the neprilysin family of endopeptidases with implications for reproduction and renal function

Autor: Josie E. Thomas, Anthony J. Turner, Nicholas D. Bland, Alan D. Shirras, R. Elwyn Isaac, Caroline M. Rylett, Richard J. Bingham, Ahmet Carhan

Publikováno v: Biochemical Journal. 386:357-366

The mammalian neprilysin (NEP) family members are typically type II membrane endopeptidases responsible for the activation/inactivation of neuropeptides and peptide hormones. Differences in substrate specificity and subcellular localization of the se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde4330d49539069dd00a0bc0913eaee
https://doi.org/10.1042/bj20041753

Repurposing human PDE4 inhibitors for neglected tropical diseases. Evaluation of analogs of the human PDE4 inhibitor GSK-256066 as inhibitors of PDEB1 of Trypanosoma brucei

Autor: Stefan O. Ochiana, Nicholas D. Bland, Robert K. Campbell, Luca Settimo, Michael P. Pollastri

Publikováno v: Chemical biologydrug design. 85(5)

Cyclic nucleotide phosphodiesterases (PDEs) have been identified as important enzyme targets for drug development in both humans and Trypanosoma brucei, the causative agent of human African trypanosomiasis. With this in mind, we recently reported the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98c1404534a3a5aa28ec0e08533476e
https://pubmed.ncbi.nlm.nih.gov/25283372

Synthesis and assessment of catechol diether compounds as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1)

Autor: Robert K. Campbell, Michael P. Pollastri, Jennifer L. Woodring, Nicholas D. Bland, Stefan O. Ochiana

Publikováno v: Bioorganicmedicinal chemistry letters. 23(21)

Human African trypanosomiasis (HAT) is a parasitic neglected tropical disease that affects 10,000 patients each year. Current treatments are sub-optimal, and the disease is fatal if not treated. Herein, we report our continuing efforts to repurpose t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7fd105b9ea1f9531782275ba723f427
https://pubmed.ncbi.nlm.nih.gov/24042005